Fast Terahertz Spectroscopic Holographic Assessment of Optical Properties of Diabetic Blood Plasma

Kulya, Maksim S.; Odlyanitskiy, E. L.; Cassar, Quentin; Мустафин, И. А.; Trukhin, V. N.; Gavrilova, Polina G.; Королев, Д. В.; Kononova, Yulia A.; Balbekin, Nikolay S.; Mounaix, Patrick; Guillet, Jean-Paul; Petrov, Nikolay V.; Smolyanskaya, O. A.

doi:10.1007/s10762-020-00728-9

Cited by 14 publications

(8 citation statements)

References 46 publications

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“…TDS-1 spectrometer is equipped with a femtosecond Ti:sapphire laser, which was used to generate THz radiation and to detect it. 26 , 31 The average wavelength was 800 nm, a pulse frequency of 80 MHz with an average power of 0.65 W, and an optical pulse length of 15 fs. The pump pulse passes through the delay line and excites an indium arsenide epilayer grown on a semi-insulator gallium arsenide wafer.…”

Section: Experiments and Methodologymentioning

confidence: 99%

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Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets

et al. 2021

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Significance: The creation of fundamentally new approaches to storing various biomaterial and estimation parameters, without irreversible loss of any biomaterial, is a pressing challenge in clinical practice. We present a technology for studying samples of diabetic and non-diabetic human blood plasma in the terahertz (THz) frequency range. Aim: The main idea of our study is to propose a method for diagnosis and storing the samples of diabetic and non-diabetic human blood plasma and to study these samples in the THz frequency range. Approach: Venous blood from patients with type 2 diabetes mellitus and conditionally healthy participants was collected. To limit the impact of water in the THz spectra, lyophilization of liquid samples and their pressing into a pellet were performed. These pellets were analyzed using THz time-domain spectroscopy. The differentiation between the THz spectral data was conducted using multivariate statistics to classify non-diabetic and diabetic groups' spectra. Results: We present the density-normalized absorption and refractive index for diabetic and nondiabetic pellets in the range 0.2 to 1.4 THz. Over the entire THz frequency range, the normalized index of refraction of diabetes pellets exceeds this indicator of non-diabetic pellet on average by 9% to 12%. The non-diabetic and diabetic groups of the THz spectra are spatially separated in the principal component space. Conclusion: We illustrate the potential ability in clinical medicine to construct a predictive rule by supervised learning algorithms after collecting enough experimental data.

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Section: Experiments and Methodologymentioning

confidence: 99%

“…Research on tableted samples can solve this problem. Our previous study has shown 26 that from the point of view of spectroscopic studies, the tableted samples absorb practically no moisture and have low absorption in the THz frequency range. Moreover, they can be conveniently fixed in a vertical holder for THz-TDS in transmission mode.…”

Section: Introductionmentioning

confidence: 99%

Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets

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“…With our THz-TDS systems, we measured pellets transmission in the spectral range of 0.2 to 1.4 THz, 17 but we know that biomolecules and in particularly its decomposition products in gas state have informative response (rotational absorption spectra) at these frequencies and lower also, thus we performed additional study on THz high-resolution gas spectrometer. The detected absorption lines of substances in diabetic human blood plasma coincide with substances of non-diabetic human blood plasma, except for acetone.…”

Section: Blood Plasma Vapors and Kidney Vapors Analysis With Using Himentioning

confidence: 99%

Terahertz high-resolution spectroscopy of thermal decomposition gas products of diabetic and non-diabetic blood plasma and kidney tissue pellets

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. Significance . One of the modern trends in medical diagnostics is based on metabolomics, an approach allowing determination of metabolites which can be the specific features of disease. High-resolution gas spectroscopy allows investigation of the gas metabolite content of samples of biological origin. We present the elaboration of a method of studying diabetic and non-diabetic biological samples, prepared as pellets, by terahertz (THz) high-resolution spectroscopy. Aim: The main idea of the work is studying the content of thermal decomposition gas products of diabetic and non-diabetic dried blood plasma and kidney tissues for revealing the set of gas-markers that characterized the diabetes by the THz high-resolution spectroscopy method. Approach: We present an approach to study the diabetic and non-diabetic blood plasma (human and rats) and kidney tissues (rats), using high-resolution spectroscopy based on the non-stationary effect of THz frequency range. The methods of preparing the blood and kidney tissue samples as pellets and of vaporizing the samples were developed. Results: The measurements of rotational absorption spectra of vapors at heating the pellets prepared from blood and kidney tissue were carried out in 118 to 178 GHz frequency range. The absorption lines appearing in spectra of the sample vapors were detected and identified. The molecular contents of thermal decomposition products differed for non-diabetic and diabetic samples; e.g., main marker is acetone appearing in the diabetic blood (human and rats) and in the diabetic kidney tissue. Conclusions: Our paper illustrates the potential ability for determining the metabolite content of biological samples for diagnostics and prognosis of diseases for clinical medicine.

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“…Additionally, many materials have high transmissivity in this frequency range. A broad range of materials, such as plastics [ 1 , 2 , 3 , 4 ], ceramics [ 5 , 6 ], illicit drugs [ 7 , 8 , 9 ], explosives [ 8 , 9 , 10 ], wood [ 11 , 12 , 13 ], paper [ 14 , 15 ], leaves [ 10 , 16 ], and blood [ 17 , 18 ] have been successfully studied with

radiation. A large number of security applications based on (sub-)THz radiation [ 8 ] have been proposed, and some are commercially available [ 8 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Real-Time High Resolution THz Imaging with a Fiber-Coupled Photo Conductive Antenna and an Uncooled Microbolometer Camera

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Shalaby²,

Söllinger³

et al. 2021

Sensors

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We present a real-time THz imaging method using a commercial fiber-coupled photo conductive antenna as the THz source and an uncooled microbolometer camera for detection. This new combination of state-of-the-art components is very adaptable due to its compact and uncooled radiation source, whose fiber coupling allows for a flexible placement. Using a camera with high sensitivity renders real-time imaging possible. As a proof-of-concept, the beam shape of a THz Time Domain Spectrometer was measured. We demonstrate real time imaging at nine frames per second and show its potential for practical applications in transmission geometry covering both material science and security tasks. The results suggest that hidden items, complex structures and the moisture content of (biological) materials can be resolved. We discuss the limits of the current setup, possible improvements and potential (industrial) applications, and we outline the feasibility of imaging in reflection geometry or extending it to multi-spectral imaging using band pass filters.

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Fast Terahertz Spectroscopic Holographic Assessment of Optical Properties of Diabetic Blood Plasma

Cited by 14 publications

References 46 publications

Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets

Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets

Terahertz high-resolution spectroscopy of thermal decomposition gas products of diabetic and non-diabetic blood plasma and kidney tissue pellets

Real-Time High Resolution THz Imaging with a Fiber-Coupled Photo Conductive Antenna and an Uncooled Microbolometer Camera

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