Study of biodegradable copoly(l-lactic acid/glycolic acid) formulations with controlled release of Z-100 for application in radiation therapy

Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the meltpressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level of testosterone (T) remained constant at approximately 0.7 ng/ml for an experimental period of 14 days, resulting in greater Leydig cell production of testosterone. This was also suggested from the results of immunohistochemical observation of the testis and weight changes of prostates, such as the ventral prostates and seminal vesicle.

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Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy

Okabe

Shibata

Mäshimo

et al. 2000

Drug Development and Industrial Pharmacy

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In Vivo Characteristics of Injectable Poly(DL-Lactic Acid) Microspheres for Long-Acting Drug Delivery

Kobayashi

Tsubuku

Yamanaka

et al. 1998

Drug Development and Industrial Pharmacy

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Poly(DL-lactic acid) (PLA) microspheres containing testosterone (T) were prepared by the solvent evaporation process to evaluate their physical properties such as size distribution, shape, drug content, in vivo controlled drug release, pharmacological influences on the prostate gland in castrated rats, and histopathological findings of tissues surrounding the implants. The in vivo release of T from PLA microspheres containing 30 mg of drug obtained with chloroform was continued over a 6-week period. This effect is attributed to high dispersibility of T in the device when obtained with chloroform. Both serum drug levels and prostate gland weight recovery suggested the effects of a long-acting drug delivery system. The histopathological findings showed that the devices used were completely degraded 10 weeks after injection.

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Study of biodegradable copoly(l-lactic acid/glycolic acid) formulations with controlled release of Z-100 for application in radiation therapy

Cited by 2 publications

References 12 publications

Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy

Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy

In Vivo Characteristics of Injectable Poly(DL-Lactic Acid) Microspheres for Long-Acting Drug Delivery

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