Study of apoptosis in human liver cancers

Abstract

In vivo the apoptosis of carcinomas was lower; maybe the cells divided quickly and then the cancers occurred. In the cancer adjacent tissues,the apoptosis pricked up, and in vivo Solanum lyratum Thumb could induce the apoptosis of BEL-7404 cells.

The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer

“…It is well documented that cytotoxic drugs exert their effects through the induction of apoptosis (Eastman and Rigas, 1999). In this experiment, Zhu-xiang showed ability to induce apoptosis in breast cancer cells in both DNA fragmentation test and TUNEL assay (Chen et al, 1999;Shan and Li, 2002). Interestingly, the apoptotic index is greater with increasing concentrations of Zhu-xiang while the proliferation index does not differ from control despite the increase in drug concentrations.…”

Ethnobotanical study of medicinal plants used by Hakka in Guangdong, China

“…Scopoletin significantly reduce the releases of glutamic pyruvic transaminase and sorbitol dehydrogenase from the carbon tetrachloride-intoxicated primary cultured rat hepatocytes (Kang et al, 1998); in vivo, treatment of liver cancers with extract of S. lyratum can induce the cells to manifest a typical apoptotic morphology (Shan and Li, 2002); in vitro, ethanol extracts of S. lyratum inhibit proliferation of BEL-7402 cells and SGC-7901 cells; in vivo, high dose of ethanol extracts inhibits the growth of S180 sarcoma-transplanted mice and H22 hepatic cancer (Ren et al, 2006) 2 searched to identify the plants' chemical compounds and clinically tested physiological effects related to hepatitis or liver protection ( Table 2). Plants of three or four species are usually used together as a decoction to treat acute hepatitis since it is believed that they can enhance the function of each other in treatment.…”

Solanum lyratumExtracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor

“…Many studies showed that Solanum lyratum extracts (SLE) inhibited proliferation in human hepatoma BEL-7402 cells, gastric carcinoma SGC-7901 cells, and melanoma A375-S2 cells in vitro and in vivo [ 16 , 17 ]. SLE also triggered apoptosis in human cervical cancer HeLa cells through Fas/Fas ligand (FasL) expression [ 18 ] promoted the activity of protein kinase A (PKA) in the gastric cancer cells [ 19 , 20 ] and provoked caspase-3-mediated apoptosis in human colon cancer colo 205 cells [ 21 ]. Additionally, SLE exhibited antitumor activity through caspase-8 and caspase-9 activations and mitogen-activated protein kinase (MAPK) regulation in Lewis lung carcinoma (LLC) cells [ 22 ].…”