Study of Antiseizure Effects of Matricaria recutita Extract in Mice

Abstract

Matricaria recutita L. is a well-known medicinal plant that is suggested as being carminative, analgesic, and anticonvulsant in traditional medicine. In the present investigation the effect of hydro-methanolic percolated extract of this plant on seizure induced by picrotoxin was studied in male mice. This study was performed on animals pretreated with doses of 100, 200, and 300 mg/kg of extract or 40 mg/kg phenobarbital as the reference drug via intraperitoneal injection. After 20 min each animal received 12 mg/kg picrotoxin for induction of seizure. Latency of onset time of seizure, duration of seizure, death latency, and death rate were determined in experimental and control groups. The results showed that latency of the beginning time of seizure was increased in groups that were pretreated with different doses of extract. The most effective dose was 200 mg/kg (P < 0.05). In addition, this dose delayed the time of death in mice (P < 0.01). The extract had no effect on the death rate. The results indicate that the extract of M. recutita possesses suitable effects on seizure induced by picrotoxin, and more experiments are needed in this field.

Chamomile: A herbal medicine of the past with a bright future (Review)

“…The recent results from the controlled clinical trial on chamomile extract for GAD suggests that it may have modest anxiolytic activity in patients with mild to moderate GAD (72). Extracts of chamomile ( M. recutita ) possess suitable effects on seizure induced by picrotoxin (73). Furthermore, apigenin has been shown to reduce the latency in the onset of picrotoxin-induced convulsions and reduction in locomotor activity but did not demonstrate any anxiolytic, myorelaxant, or anticonvulsant activities (16).…”

Synthesis of Some Azoles Incorporating a Sulfonamide Moiety as Anticonvulsant Agents

“…Anticonvulsant activity was determined according to the picrotoxin (PIC) method 18–20. The following parameters were recorded during these sessions: latency, status of animal after 30 min, the number of protected animals, and the effect of each compound on the mortality rate was calculated.…”

Review of the use of botanicals for epilepsy in complementary medical systems — Traditional Chinese Medicine

“…Research with animals supports the antispasmodic, anxiolytic, anti-inflammatory, antimutagenic, and cholesterol-lowering effects of chamomile [77]. Its anticonvulsant effects are mainly related, in part, to linoleic acid and/or flavonoid compounds present in the extract [78]. Apigenin, a flavonoid isolated from M. chamomilla, is the potential active ingredient for the anticonvulsant effect, which could reduce the latency in the onset of PTZ-induced convulsions [79].…”