Review of the use of botanicals for epilepsy in complementary medical systems — Traditional Chinese Medicine

Xiao, Fenglai; Yan, Bo; Chen, Lei; Zhou, Dong

doi:10.1016/j.yebeh.2015.04.050

Cited by 70 publications

(28 citation statements)

References 103 publications

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“…[14,15]. TCM is often considered to be a gentle and safe way to synthetically manufacture drugs, and it is the most widely practiced form of herbalism worldwide [7]. FCP is a TCM formula widely used for treating epilepsy in Chinese folk medicine.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anticonvulsant and sedative effect of <i>Fufang Changniu</i> pills and probable mechanism of action in mice

Zhang¹,

Lu²,

Zhang³

et al. 2016

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

“…Over thousands of years, TCMs including a variety of botanicals and herbs were used to treat epilepsy [7]. Fufang Changniu Pills (FCP) is a commonly used TCM formula which consists of Acori Tatarinowii Rhizoma, Pharbitidis Semen, Cinnamomi Ramulus, Polygalae Radix, Uncariae Ramulus Cum Uncis, and Glycyrrhizae Radix Et Rhizoma (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant and sedative effect of <i>Fufang Changniu</i> pills and probable mechanism of action in mice

Zhang¹,

Lu²,

Zhang³

et al. 2016

Trop. J. Pharm Res

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“…A review has reported that most seizure types were only confined to generalized tonic-clonic seizures (GTCS) by Huang Di Nei Ching, other subsequent publications [13], and in the description in the latest version textbook for undergraduate, Chinese Internal Medicine; "xianzheng" was described as a "sudden loss of consciousness, upward staring eyes, drool foaming at the mouth, tonic convulsion, bawl and squall" [10]. It is undeniable that GTCS was the most common and the most easily observed seizure type.…”

Section: Limits Of the Definition Of "Xianzheng" In Chinese Internal mentioning

confidence: 99%

Traditional Chinese Herbal Medicine for Epilepsy Treatment Should Be Administered According to the Seizure Type and Epileptic Syndrome

Cai¹

2017

Health

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Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in epileptic patients has not been certified because of insufficient supportive evidence. This insufficient supportive evidence stems from the fact that most of the current studies regarding TCHM for epilepsy treatment are not designed according to the different seizure types and epileptic syndromes (STESs). Here, we explore the reasons why many studies have not considered the various STESs and explain how to treat epilepsy according to the pharmacological mechanism for different STESs and exploit the advantage of TCHM for epilepsy treatment. Then, we explain how we treat epilepsy using TCHM according to the different STESs and Bian Zheng Lun Zi.

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“…For example, Xiao et al (1) started their review by describing the TCM classification of epilepsy and how the principles of TCM are applied to patients in combining herbs with other treatment modalities, such as acupuncture, massage, diet, and therapeutic exercise. They then provided a comprehensive overview of botanicals in current use in TCM based on an extensive search of PubMed and numerous Chinese databases, as well as hand searches of numerous Chinese journals and the latest Chinese pharmacopeia.…”

Section: Example Of Traditional Chinese Medicinementioning

confidence: 99%

Translating Nature to Nurture: Back to the Future for “New” Epilepsy Therapies

Schachter

2015

Epilepsy Curr

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An emerging strategy for finding new epilepsy therapies is focused on botanicals (as illustrated by recent attention to medical marijuana), given their centuries-old traditions of use in treatment of convulsive seizures, contemporary anecdotal reports of efficacy in persons with epilepsy, and identification of underlying mechanisms of action that are relevant to epilepsy. Hundreds of plant extracts have been found to block seizures in acute animal seizure models, with actions that include effects on GABA receptors and voltage-gated ion channels as well as anti-inflammatory and neuroprotective effects. While existing published clinical studies of botanicals and seizure control are generally of inadequate quality to determine safety and efficacy, recent developments at the FDA may encourage sponsors to develop and commercialize botanicals for epilepsy.

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Review of the use of botanicals for epilepsy in complementary medical systems — Traditional Chinese Medicine

Cited by 70 publications

References 103 publications

Anticonvulsant and sedative effect of <i>Fufang Changniu</i> pills and probable mechanism of action in mice

Anticonvulsant and sedative effect of <i>Fufang Changniu</i> pills and probable mechanism of action in mice

Traditional Chinese Herbal Medicine for Epilepsy Treatment Should Be Administered According to the Seizure Type and Epileptic Syndrome

Translating Nature to Nurture: Back to the Future for “New” Epilepsy Therapies

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