Study of antimicrobial qualities of antiseptic remedies, which contain decamethoxin

Гончар, О. О.; Назарчук, Олександр; Paliy, D. V.; Коваленко, И. В.; Yatsula, O. V.

doi:10.24959/ubphj.16.15

Cited by 2 publications

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“…In vitro, MBcC of the DCM ® substance depends on the type of microorganism and pH, with the lowest values for S. aureus, P. aeruginosa in an alkaline medium (pH 8.0±0.1) -0.62 and 25.0 μg/ml, respectively [18]. At the same time, the sensitivity of Staphylococcal strains to DCM ® in the presence of MBcC, which is in the range of 3.9-7.8 μg/ml, ensures the effective use of this antiseptic in clinical conditions [6], which is additionally confirmed in some studies [1,4,9,10,13,17]. However, in the presence of 10% of blood serum proteins, MBcC DCM ® increases up to 8 times, while in the presence of 5% of blood serum proteins, this concentration decreases by two times [19,20,21].…”

Section: Characteristics Of Antimicrobial Activity Of Dcm ® In Vitro ...mentioning

confidence: 77%

“…It was analyzed that DCM ® has an antimicrobial effect on museum and clinical strains of microorganisms S. aureus, E. coli, P. aeruginosa, C. albicans, K. pneumoniae. The sensitivity of Staphylococcal strains to DCM ® in the presence of minimum bactericidal concentration, which is in the range of 3.9-7.8 μg/ml, ensures the effective use of this antiseptic in clinical conditions [6], which is additionally confirmed in some studies [1,4,9,10,13,17].The drug exhibits a fungicidal effect against C. albicans (n 10) -within 8.19±1.85 μg/ml [21]. It was established that decamethoxin potentiates the antibacterial effect of β-lactamson resistant strains of Staphylococcus by 128 times and destroys resistance plasmids, which prevents the emergence and spread of antibiotic resistance [16].…”

Section: Discussionmentioning

confidence: 91%

“…DCM ® has an antimicrobial effect on museum strains of microorganisms S. aureus ATCC 25923, E. coli ATCC 25922, P. aeruginosa ATCC 27853, C. albicans CCM 885, and clinical strains polyresistant to antibiotics S. aureus (n 85), E. coli (n 22), P. aeruginosa (n 16), C. albicans (n 12) with the minimum bactericidal concentration (MBcC) for S. aureus (3.67±2.71 μg/ml) and E. coli (26.8 ±17.5 μg/ml). At the same time, clinical strains of P. aeruginosa showed resistance, and C. albicans showed moderate sensitivity [17]. It was analyzed that a high MBcC characterizes DCM ® in relation to 130 strains of S. aureus (1.45±0.1 μg/ml) and 120 strains of E. coli (5.99±0.37 μg/ml), in particular, Escherichia (15,6-31.2 μg/ml), Bac.…”

Section: Characteristics Of Antimicrobial Activity Of Dcm ® In Vitro ...mentioning

confidence: 99%

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Effectiveness of Using Domestic Quaternary Ammonium Antiseptic in General Medicine and Dentistry (Modern View and Clinical Case)

Bezhuk

Hodovana

2023

Proc Shevchenko Sci Soc Med Sci

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Decamethoxine (DCM®) is a substance from a group of quaternary ammonium compounds. According to literary sources, the antimicrobial effect is due to a mechanism that combines damage to the cell membrane of bacteria and lysis of their protoplasts, as well as changes the permeability of the microbial cell membrane, causing its destruction. DCM® demonstrates activity against gram-positive and gram-negative bacteria (staphylococci, streptococci, diphtheria and Escherichia coli, salmonella, proteus, klebsiella, shigella, pseudomonads, clostridia), some fungi (yeast fungi, mold fungi). There are also reports of the antiviral activity of this compound. The purpose of this study was to highlight the results of the current work of Ukrainian scientists and analyze the properties and broad aspects of DCM® antiseptic, as well as demonstrate their clinical case for its effectiveness in periodontal practice. The analysis of the results of various publications allowed us to evaluate the full range of DCM® properties in terms of its therapeutic potential in modern preclinical and clinical studies, particularly in periodontal practice.

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Section: Characteristics Of Antimicrobial Activity Of Dcm ® In Vitro ...mentioning

confidence: 77%

Section: Discussionmentioning

confidence: 91%

Section: Characteristics Of Antimicrobial Activity Of Dcm ® In Vitro ...mentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Using Domestic Quaternary Ammonium Antiseptic in General Medicine and Dentistry (Modern View and Clinical Case)

Bezhuk

Hodovana

2023

Proc Shevchenko Sci Soc Med Sci

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Peculiarities of the wound healing process in the acute period of burn disease depending on the antiseptic used

Nahaichuk

Назарчук

Chornopyshchuk

et al. 2019

prmd

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Background. Burn injury, as one of the most common types of trauma, requires a comprehensive approach to treatment, including surgical and conservative treatment with effective post-burn wound protection. One of the main obstacles to wound healing is purulent-infectious complications, for prevention of which antiseptics are widely used. The aim is to study the microbiological, histological features of the wound healing course in the acute period of burn disease with the use of various antiseptics. Materials and methods. In the research there were involved 44 patients with burns (burn area 10–20 % of the body surface), treated in the Clinical Center for Thermal Injury and Plastic Surgery of Communal Non-Commercial Enterprise “Vinnytsia Regional Clinical Hospital named after M. I. Pirogov” (2018–2019). Depending on the antiseptic therapy, these patients were divided into three observation groups. Patients in the 1st study group (n = 15; mean age 48.07 ± 12.05 years) were treated with 2.0 % povidone-iodine during dressing. In the 2nd group (n = 15; mean age – 48.53 ± 14.76 years) antiseptic based on 0.02 % decamethoxin was used. In patients of the comparison group (n = 14; mean age – 47.71 ± 12.39 years) a solution of 10.0 % NaCl was administrated for topical wound management. Microbiological assessment of the condition of the wound surface (on 3, 7, 14, 21 days) and histological examination of tissue samples from the bottom of the wound (on 3, 7, 14 days) were carried out by means of standard methods. Results. Under the use of antiseptic agents based on 2.0 % povidone-iodine and 0.02 % decamethoxin during the treatment period in patients with burns up to 14 days, an effective reduction in the number of conditionally pathogenic microorganisms on the wound surface to lg (4.8 ± 0.4) and lg (3.06 ± 0.5) CFU/ml, respectively, was registered and it was significantly 1.5 times lower than that based on 10 % sodium chloride solution (p < 0.05). When applying decamethoxin for 14 days at the same time as the eradication of conditionally pathogenic microorganisms, moderate colonization of wounds was registered by representatives of normal skin microbiota (Corynebacterium spp., S. epidermidis). Histologically, there was found that with the use of 2.0 % povidone-iodine, the wound healing course was accompanied by a marked decrease in inflammation signs, as well as a pronounced inhibition of the formation of granulation tissue (10–14 days). The use of 0.02 % decamethoxin was accompanied by the formation of granulation tissue of sufficient maturity for atodermoplasty, in the presence of signs of inflammatory cellular reaction with the presence in the superficial parts of the bottom of the post-burn wounds of the fibrinoid layer, with signs of permanent formation of new hemocapillaries in it, surrounded by a thin argyrophilic mesh. When using a hypertonic sodium chloride solution before autodermoplasty, the granulation tissue had signs of uneven inflammatory cell infiltration. Signs of leukocyte-necrotic tissue changes, fibrinoid-leukocyte layers with fragments of tissue detritus, signs of resuscularization of granulation tissue were recorded. Conclusion. Microbiological data strongly suggest the efficacy of 0.02 % decamethoxin and 2.0 % povidone-iodine in reducing microbial wound colonization infection compared to 10.0 % NaCl. The use of antiseptics and hypertonic sodium chloride solution in the acute period of burn disease provides a marked reduction in histological signs of inflammation in the wound with a noticeable positive effect of decamethoxin and 10.0 % NaCl on the formation of granulations and their revascularization compared with povidone-iodine (p < 0.001).

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Study of antimicrobial qualities of antiseptic remedies, which contain decamethoxin

Cited by 2 publications

References 0 publications

Effectiveness of Using Domestic Quaternary Ammonium Antiseptic in General Medicine and Dentistry (Modern View and Clinical Case)

Effectiveness of Using Domestic Quaternary Ammonium Antiseptic in General Medicine and Dentistry (Modern View and Clinical Case)

Peculiarities of the wound healing process in the acute period of burn disease depending on the antiseptic used

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