Study of Antimicrobial activity of Star Anise loaded poly (DL-lactide-co-glycolide) nanoparticles

Kumari, Vinod; Sangal, Aditi

doi:10.5958/0974-360x.2019.00088.x

Cited by 3 publications

(1 citation statement)

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“…These results can be explained by the differences in the cell wall structure of these bacteria, since the absence of an outer cell membrane and periplasm in the Gram-positive bacteria allows higher molecules permeability, while the Gram-negative are capable of restricting diffusion of hydrophobic molecules through its lipopolysaccharide envelope reducing penetration [25,26]. From the group, the HCO, SAO, and WO did not form any ZoI even though reports have been published on their antibacterial action [27][28][29]. This supports the premise established by Tavares et al that the plant origin and the extraction methods of natural products employed by each company may influence the properties of the final product [5].…”

Section: Agar-well Diffusionmentioning

confidence: 99%

Physical, Thermal, and Antibacterial Effects of Active Essential Oils with Potential for Biomedical Applications Loaded onto Cellulose Acetate/Polycaprolactone Wet-Spun Microfibers

et al. 2020

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New approaches to deal with the growing concern associated with antibiotic-resistant bacteria are emerging daily. Essential oils (EOs) are natural antimicrobial substances with great potential to mitigate this situation. However, their volatile nature, in their liquid-free form, has restricted their generalized application in biomedicine. Here, we propose the use of cellulose acetate (CA)/polycaprolactone (PCL) wet-spun fibers as potential delivery platforms of selected EOs to fight infections caused by Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Twenty EOs were selected and screened for their minimal inhibitory concentration (MIC), using the antibiotic ampicillin as positive control. The cinnamon leaf oil (CLO), cajeput oil (CJO), and the clove oil (CO) were the most effective EOs, against the Gram-positive (MIC < 22.38 mg/mL) and the Gram-negative (MIC < 11.19 mg/mL) bacteria. Uniform microfibers were successfully wet-spun from CA/PCL with an averaged diameter of 53.9 ± 4.5 µm, and then modified by immersion with CLO, CJO and CO at 2 × MIC value. EOs incorporation was confirmed by UV-visible spectroscopy, Fourier-transformed infrared spectroscopy, and thermal gravimetric analysis. However, while microfibers contained ampicillin at MIC (control) after the 72 h modification, the CLO, CO and CJO-loaded fibers registered ≈ 14%, 66%, and 76% of their MIC value, respectively. Data showed that even at small amounts the EO-modified microfibers were effective against the tested bacteria, both by killing bacteria more quickly or by disrupting more easily their cytoplasmic membrane than ampicillin. Considering the amount immobilized, CLO-modified fibers were deemed the most effective from the EOs group. These results indicate that CA/PCL microfibers loaded with EOs can be easily produced with increased antibacterial action, envisioning their use as scaffolding materials for the treatment of infections.

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Section: Agar-well Diffusionmentioning

confidence: 99%

Physical, Thermal, and Antibacterial Effects of Active Essential Oils with Potential for Biomedical Applications Loaded onto Cellulose Acetate/Polycaprolactone Wet-Spun Microfibers

et al. 2020

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In-Vitro kinetic release study of illicium verum (Chakraphool) polymeric nanoparticles

Kumari

Tyagi

Sangal

2022

Materials Today: Proceedings

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Formulation and In-vitro Antibacterial Activity of Gel containing Ethanolic extract of Purple Sweet Potato Leaves (Ipomoea batatas (L.) Loaded Poly Lactic Co-Glycolic Acid Submicroparticles against Staphylococcus aureus

Mardiyanto

Apriani

Alfarizi

2022

RJPT

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Staphylococcus aureus has been resistant to various antibiotics including erythromycin, clindamycin, penicillin, trimethoprim-sulfamethoxazole, tetracyclines, chloramphenicol, and piperacillin-tazobactam so that an alternative treatment is needed. The purple sweet potato leaves (Ipomoea batatas (L.) Poir) contain flavonoid compounds that have antibacterial activity by inhibiting nucleic acid, protein synthesis, cell membrane, and energy metabolism in bacteria. In this study, ethanolic extract of purple sweet potato leaves is loaded to poly lactic-co-glycolic acid submicroparticles to increase the stability of flavonoids and the antibacterial effect. Submicroparticle gel was prepared with various concentrations of hydroxypropyl methylcellulose ie F1, F2, and F3 respectively 3%, 5%, and 7%. The antibacterial activity of submicroparticles gel compared with a gel containing extracts without submicroparticle and erythromycin gel as a positive control. Phytochemical test results that the ethanolic extract of purple sweet potato leaves contains flavonoids. Based on the research results, the best formula was F1(3%) with pH, homogeneity, viscosity, dispersibility, adhesion, and washability, respectively 7.4±0.0361; homogeneous; 8358.9±228.1391 cps; 4.2667±0.3005cm; 45.333±2.5166 seconds; 11.6667±1.5275mL. F1 was also shown to have strong antibacterial activity with an inhibition zone value of 13.67±4.04mm.

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Study of Antimicrobial activity of Star Anise loaded poly (DL-lactide-co-glycolide) nanoparticles

Cited by 3 publications

References 0 publications

Physical, Thermal, and Antibacterial Effects of Active Essential Oils with Potential for Biomedical Applications Loaded onto Cellulose Acetate/Polycaprolactone Wet-Spun Microfibers

Physical, Thermal, and Antibacterial Effects of Active Essential Oils with Potential for Biomedical Applications Loaded onto Cellulose Acetate/Polycaprolactone Wet-Spun Microfibers

In-Vitro kinetic release study of illicium verum (Chakraphool) polymeric nanoparticles

Formulation and In-vitro Antibacterial Activity of Gel containing Ethanolic extract of Purple Sweet Potato Leaves (Ipomoea batatas (L.) Loaded Poly Lactic Co-Glycolic Acid Submicroparticles against Staphylococcus aureus

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