Study of anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats

Naik, Manas Ranjan; Bhattacharya, Akash; Behera, Rasmirekha; Agrawal, Divya; Dehury, Suhasini; Kumar, Sanjay

doi:10.4103/2394-2010.153880

Cited by 42 publications

(41 citation statements)

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“…A dose of 2 ml / kg body weight extract showed 53.12% inhibition of edema. X [18] Leaves Aqueous extract Immunomodulator, growth promoter. Greater weight gain, breast in the 50 ml infusion group.…”

Section: Anti-inflammatory Undefinedmentioning

confidence: 99%

“…Overtime, research has shown that triterpenes lead the way as the key compounds [17,18], with other important-derived metabolites like: flavonoids, limonoids, saponins, tannins (Azadirachtin and nimbins), catechins and gallic acid [17,18], as seen on Figure 2. In addition, the leaf of the Neem tree appears to have developed a particular set of glycoproteins: such as neem leaf glycoprotein (NLGP) that when tested on mammalian subjects, show important immune-modulators, providing the potential to restrict tumor growth by modulating local and systemic immunity [19][20][21][22].…”

Section: Bioactive Compounds Present In Azadirachta Indicamentioning

confidence: 99%

“…In addition, the leaf of the Neem tree appears to have developed a particular set of glycoproteins: such as neem leaf glycoprotein (NLGP) that when tested on mammalian subjects, show important immune-modulators, providing the potential to restrict tumor growth by modulating local and systemic immunity [19][20][21][22]. Further, indepth phytochemical analysis of the oil, has confirmed triterpenes, flavonoids and saponins as the primary compounds found, while other components such as: catechins and nimbins, seem to be present in lower amounts [17,18]. Triterpenes are known to be the primary structure on which the major metabolites as founded on.…”

Section: Bioactive Compounds Present In Azadirachta Indicamentioning

confidence: 99%

“…Limonoid is a furanolactone, known for its inhibitory properties in the production of inflammatory mediators. It is known as a pain anesthetizer, as it stimulates the activation of endogenous opioid pathways [17,18,35]. Soares et al, showed that, limonoid extracted from Neem, can inhibit edema and fibrovascular tissue growth when tested on damage rat paws.…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

“…In the body, inflation lead to the activation of the cyclooxygenase pathway, and the inhibition of cyclooxygenases 1 and 2 (COX1, COX2) by Neem has been a widely studied topic [44]. We previously [17,18]. We can now relate these compounds to the modulation of inflammation by relating to the eicosanoid metabolism (prostaglandin and thromboxane production).…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

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Current Evidence about Neem Extracts, the Molecules and Physiological Mechanisms Their Nutritional Components Interact with

Islas¹,

Acosta²,

Escalante-Acosta³

et al. 2019

Preprint

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Plant-based alternative medicine is normally grounded on empiric cultural perception, as the main objective, these practices intent to either maintain good health or to provide a route to turn-the-tide on a specific disease or ailment. Amongst the thousands of plants that have been used and studied, Neem (Azadirachta indica) seems to have a very interesting tale to tell, since its properties to ward-off certain diseases have overtime, and in a rigorous way, been proven. The preceding concise review is a collection of some of the most relevant studies today, not only focusing on the health benefits obtained by its use, but digging into the molecular mechanisms of how the properties come about. In particular, we take a look over antioxidant properties and how these mediate and mitigate important molecules such as IL-6 and TNF-, leading the way in reducing systematic damage by oxidative stress. Further, we relate this oxidative reduction to other systemic diseases such as cancer and diabetes, as these are currently becoming the most rampant killers. As of yet not all is known about the different ways of extracting or the total composition of an extract, as these may be from different parts of the plant. Therefore, we also allude to an important cautionary view where toxicological effects and conflicting outcomes arise. Overall, presented results show a great potential for the different extracts of Neem as their antioxidant activity can be taken advantage off, and potentially used in modern medicine.

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Section: Anti-inflammatory Undefinedmentioning

confidence: 99%

Section: Bioactive Compounds Present In Azadirachta Indicamentioning

confidence: 99%

Section: Bioactive Compounds Present In Azadirachta Indicamentioning

confidence: 99%

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Section: Anti-inflammatory Effectmentioning

confidence: 99%

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Current Evidence about Neem Extracts, the Molecules and Physiological Mechanisms Their Nutritional Components Interact with

Islas¹,

Acosta²,

Escalante-Acosta³

et al. 2019

Preprint

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Herbal Formulations as Denture Cleansers

Bhochhibhoya,

Shrestha,

Shrestha

et al. 2023

Pharmacological Studies in Natural Oral Care

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Anti‐inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate the domestication of alternative medicine

Sudhakaran

Prathap

Guru

et al. 2022

Cell Biology International

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Human health may benefit from the study of natural compounds and phytoconstituents that can protect from inflammation. We investigated Nimbin (N1), a member of the ring C Seco-tetranortriterpenoids family, and its semi-natural analog deacetyl Nimbin namely N2 and N3 for their anti-inflammatory properties. As key findings, N1, N2, and N3 were able to improve wound healing by cell proliferation in a period of 24 h and were able to reduce the reactive oxygen species (ROS) production in Madin-Darby Canine Kidney cells which were screened using dichlorodihydro fluorescein diacetate (DCF-DA) staining. When the zebrafish larvae were subjected to DCF-DA assay N1, N2, and N3 were able to substantially reduce the ROS levels in a dose-dependent manner. In zebrafish larvae, the cell death indicates the fluorescent intensity due to acridine orange staining that was found to be dramatically decreasing upon the treatment of N1, N2, and N3. The cell membrane lipid peroxidation levels were also reduced in a dose-dependent manner upon the treatment of Nimbin and its analogs indicating lesser blue fluorescent levels. Among the Nimbin and its analogs, N2 was subjected to have better activity. To confirm the activity of N1, N2, and N3, in silico characterization was performed using Density functional theory and molecular docking. As a result, N2 exhibited the lowest

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Study of anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats

Cited by 42 publications

References 1 publication

Current Evidence about Neem Extracts, the Molecules and Physiological Mechanisms Their Nutritional Components Interact with

Current Evidence about Neem Extracts, the Molecules and Physiological Mechanisms Their Nutritional Components Interact with

Herbal Formulations as Denture Cleansers

Anti‐inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate the domestication of alternative medicine

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