Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin

Liu, Zhidong; Li, Jiawei; Nie, Song; Liu, Hui; Ding, Pingtian; Pan, Weisan

doi:10.1016/j.ijpharm.2006.01.029

Cited by 219 publications

(120 citation statements)

References 15 publications

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“…Preparations of Gelrite are dropped into eyes; gel formation takes place, induced by the electrolytes of the tear fluid (19). The other in situ gelling compound examined, sodium alginate, is widely used in pharmaceutical preparation (20,21). Similarly, aqueous solutions of alginate (a natural polysaccharide extracted from brown sea algae) also form gels when instilled into the eye.…”

Section: Introductionmentioning

confidence: 99%

In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery

Liu

Zhang

et al. 2010

AAPS PharmSciTech

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Abstract. The objective of this study was to develop an ion-activated in situ gelling vehicle for ophthalmic delivery of matrine. The rheological properties of polymer solutions, including Gelrite, alginate, and Gelrite/alginate solution, were evaluated. In addition, the effect of formulation characteristics on in vitro release and in vivo precorneal drug kinetic of matrine was investigated. It was found that the optimum concentration of Gelrite solution for the in situ gel-forming delivery systems was 0.3% (w/w) and that for alginate solution was 1.4% (w/w). The mixture of 0.2% Gelrite and 0.6% alginate solutions showed a significant enhancement in gel strength at physiological condition. On the basis of the in vitro results, the Gelrite formulations of matrine-containing alginate released the drug most slowly. For each tested polymer solution, the concentration of matrine in the precorneal area was higher than that of matrinecontaining simulated tear fluid (STF) almost at each time point (p<0.05). The area under the curve of formulation 16 (0.2%Gelrite/0.6%alginate) was 4.65 times greater than that of containing matrine STF. Both the in vitro release and in vivo pharmacological studies indicated that the Gelrite/alginate solution had the better ability to retain drug than the Gelrite or alginate solutions alone. The tested formulation was found to be almost non-irritant in the ocular irritancy test. The overall results of this study revealed that the Gelrite/alginate mixture can be used as an in situ gelling vehicle to enhance ocular retention.

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Section: Introductionmentioning

confidence: 99%

In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery

Liu

Zhang

et al. 2010

AAPS PharmSciTech

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“…In vivo precorneal retention studies also indicated that the alginate-HPMC solution retained the drug better than the alginate or HPMC solutions alone. Excellent ocular tolerance was reported without any sign of irritation with all the formulations [16].…”

Section: Poly (N-isopropylacrylamide)mentioning

confidence: 87%

“…Sodium alginate forms three dimensional hydrogel and the high G content alginate forms a low viscosity, free-flowing liquid at concentrations suitable for gel formation in the lacrimal fluid [16]. Alginate transforms into stable gel upon exposure to divalent cations, which is not easily eroded by tear fluid.…”

Section: Poly (N-isopropylacrylamide)mentioning

confidence: 99%

“…A wide variety of drug molecules and materials of therapeutic advantages such as antibiotics (Ofloxacin, Ciprofloxacin, Gatifloxacin), beta blockers (Timolol, Carteolol), NSAIDs (Ketorolac Tromethamine, Indomethacin), Pilocarpine hydrochloride, Puerarin, Recombinant rhEGF, Antivirals (Acyclovir) has been delivered through in situ gelling systems, which shows the importance of in situ gelling formulations as the future drug delivery systems [7][8][9][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Jain¹,

Kumar²,

Singh³

et al. 2016

JAPLR

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In situ -gelling systems has the great potential in the wide areas of drug delivery. The application areas of such systems are broad and these systems can be formulated not only as gels but also as in situ gelling nanospheres, microspheres and liposomes. To overcome the drawbacks associated with conventional drug delivery systems and take advantages of both solutions and gels, such as accurate dosing, ease of administration of the former and longer precorneal residence of the latter, a newer concept of in situ gelling drug delivery systems was came in light for the first time in the early 1980s. In situ gelling systems are the polymeric solutions which can be administered in solution form and immediately undergoes sol-gel phase transition in to a viscoelastic gel upon exposure to physiological conditions (e.g. pH, temperature and ionic concentration) or application of external triggers. In situ gelling systems seems to have wide applications in ocular therapy. A lot of research is going on in this area proves the fact that in situ gelling systems can be advantageous in the ocular drug delivery. In the present review we will discuss recent researches involving application of in situ gelling polymers, their applications in the various domains of drug delivery and marketed formulations based on in situ gelling systems.

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“…Water-soluble hydrophilic polymers hydroxypropylmethylcellulose helps to increase viscosity from 400cps up to about 15,000cps as well as increasing lacrimal film stability which helps to increase residence time of drug in the cul-de-sac and thus helps increasing the absorption and eventual bioavailability [88,89].…”

Section: Topical Ophthalmic Preparationsmentioning

confidence: 99%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

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There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

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Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin

Cited by 219 publications

References 15 publications

In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery

In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

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