Study of acute hepatotoxicity of Equisetum arvense L. in rats

Baracho, Nilo César do Vale; Vicente, Bruno Battiston Vilela; Arruda, Guilherme D’Andréa Saba; Sanches, Brunno Cezar Framil; Brito, Jarbas de

doi:10.1590/s0102-86502009000600005

Cited by 18 publications

(11 citation statements)

References 7 publications

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“…These levels of ALP were comparable to those recorded for two studies of Equisetums toxicity in rats ( (Tago et al, 2010;Baracho et al, 2009).…”

Section: Discussionsupporting

confidence: 85%

“…Acute hepatoxicity was not observed in our study, which utilized doses of Equisetum ramossisemum extract at 500, 250, and 125 mg/kg. However, a study has shown that high doses of Equisetum arvense in rats produced significant hepatic damage (Baracho et al, 2009). In contrast, another study found that regular doses of Equisetum arvense have a hepatoprotective effect in rats (Baracho et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

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Assessing effects of <i>Equisetum ramosissimum</i> extract on hematological and serum biochemical parameters in pregnant Sprague-Dawley rats

Alebous¹,

Hudeb²,

Sober³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: As a medicinal herb, Equisetum ramossisemum has been utilized for centuries as a diuretic and has been recommended for different disorders. The aim of this study was to investigate the maternal toxicity of aerial parts of Equisetum ramosissimum extract on pregnant Sprague-Dawley rats. Methods: Females were mated and the coupling time was recorded at gestation day 0-E0. Four experimental groups I, II, III, and IV, received daily gavage doses of 0 mg, 500 mg, 250 mg, and 125 mg/kg, respectively, of Equisetum ramosissimum extract. Pregnant rats were observed for mortality and toxicological effects during daily treatment. On day E20, samples of blood were withdrawn from the retro-orbital sinus under light ether anaesthesia for haematological and clinical chemistry examinations. Results: Data analyses detected significant differences in biochemical and haematological parameters between the control group and other groups receiving extract. Conclusion: This study constitutes a first approach to defining adverse effects of using Equisetum ramosissimum as a medicinal plant during pregnancy. Daily gavage doses of Equisetum ramosissimum extract produced significant differences in biochemical and haematological parameters in pregnant Sprague-Dawley rats as compared to the control group.

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“…These levels of ALP were comparable to those recorded for two studies of Equisetums toxicity in rats ( (Tago et al, 2010;Baracho et al, 2009).…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Assessing effects of <i>Equisetum ramosissimum</i> extract on hematological and serum biochemical parameters in pregnant Sprague-Dawley rats

Alebous¹,

Hudeb²,

Sober³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…Our experimental data confirm the ethnopharmacology and traditional use of E. arvense as a diuretic, which occurs worldwide, including in Brazil and other South American countries [5, 10, 16–18, 25, 30] and in several European [4, 6–9, 11, 25] and Asian countries [4, 13–15, 24]. These results represent a major stimulus for further clinical studies of the other pharmacological effects of E. arvense and other medicinal plants with broad scopes in traditional medicine.…”

Section: Resultssupporting

confidence: 80%

“…Preclinical studies have revealed various pharmacological actions of Equisetum arvense , including antioxidant [11, 13] and antidiabetic [14, 15] properties, but no acute hepatotoxicity [16]. …”

Section: Introductionmentioning

confidence: 99%

Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect ofEquisetum arvense(Field Horsetail) in Healthy Volunteers

Carneiro

Freire

Honório

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups (n = 12) that underwent a three-step treatment. For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900 mg/day), placebo (corn starch, 900 mg/day), or hydrochlorothiazide (25 mg/day), separated by a 10-day washout period. Each volunteer served as his own control, and the groups' results were compared. We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug. The diuretic effect of EADE was assessed by monitoring the volunteers' water balance over a 24 h period. The E. arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes. There was no significant increase in the urinary elimination of catabolites. Rare minor adverse events were reported. The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use. Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.

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“…Hepatic tissue samples were collected for the anatomopathologic analysis. The anatomopathologic exam of the hepatic tissue showed lobular structure, however, there was no significant change in the activities of the hepatic enzymes when compared to control group [111].…”

Section: Side Effects Contraindications and Toxicitymentioning

confidence: 69%

The pharmacology of Equisetum arvense- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-The previous studies revealed that Equisetum arvense contained alkaloids, carbohydrate, proteins and amino acids, phytosterols, saponins, sterols, ascorbic acid, silicic acid, phenol , tannin, flavonoids, triterpenoids, volatile oils and many other biological active constituents. The pharmacological studies showed that it possessed antioxidant, anticancer, antimicrobial, smooth muscle relaxant effects of the vessels and ileum, anticonvulsant, sedative, anti-anxiety, dermatological immunological, antinociceptive, anti-inflammatory, antidiabetic, diuretic, inhibition of platelet aggregation, promotion of osteoblastic response, anti-leishmanial, and many other effects. The current review highlights the chemical constituents and pharmacological effects of Equisetum arvense.

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Study of acute hepatotoxicity of Equisetum arvense L. in rats

Abstract: The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.

Cited by 18 publications

References 7 publications

Assessing effects of <i>Equisetum ramosissimum</i> extract on hematological and serum biochemical parameters in pregnant Sprague-Dawley rats

Assessing effects of <i>Equisetum ramosissimum</i> extract on hematological and serum biochemical parameters in pregnant Sprague-Dawley rats

Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect ofEquisetum arvense(Field Horsetail) in Healthy Volunteers

The pharmacology of Equisetum arvense- A review

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