Study of a water-soluble supramolecular complex of curcumin and β-cyclodextrin polymer with electrochemical property and potential anti-cancer activity

Zhang, Wang; Xiao, Ping; Lin, Liwei; Guo, Fang; Wang, Qingyue; Piao, Yuanzhe; Diao, Guowang

doi:10.1016/j.cclet.2021.12.037

Cited by 37 publications

(14 citation statements)

References 48 publications

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“…The stoichiometric ratio of the host and guest molecules using the integrated peak ratio of host/guest molecule was calculated in our previous study [ 14 ]. According to the results in Figure 3 A and Table 1 , the OH-2 of β -CDP and H-a of DPG do not overlap with other peaks.…”

Section: Resultsmentioning

confidence: 99%

“…A water purification system was used to obtain disinfected twice-distilled water. β -CDP was synthesized under a previously reported protocol [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…CDP can improve the water solubility and biological activity of CD, which exhibits structural rigidity and low solubility. In recent years, CDP has been reported to retain the inclusion properties of CD monomers, improve the water solubility of CD, and show good stability and chemical tenability [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Guo

Lin²,

Wang³

et al. 2022

Molecules

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Diphenylguanidine (DPG) is a widely used secondary accelerator for the vulcanization of natural rubber (NR) latex. However, its low water solubility and high toxicity limit its use in high-end NR products. In this study, a water-soluble inclusion complex of DPG and a β-cyclodextrin polymer (β-CDP), termed DPG-β-CDP, was prepared through supramolecular interactions and characterized using Fourier-transform infrared spectroscopy, 1H NMR, scanning electron microscopy, and UV-vis spectroscopy techniques. In comparison with that of DPG, the water solubility of DPG-β-CDP was greatly enhanced because of the water-soluble host molecule. The molar ratio of DPG to the CD unit in β-CDP was determined to be 1:1. At 25 °C, the binding constant of DPG-β-CDP was found to be 9.2 × 105 L/mol by UV-vis spectroscopy. The proposed method for forming inclusion complexes with high potential for use as water-soluble vulcanization accelerators is promising.

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Section: Resultsmentioning

confidence: 99%

“…A water purification system was used to obtain disinfected twice-distilled water. β -CDP was synthesized under a previously reported protocol [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Guo

Lin²,

Wang³

et al. 2022

Molecules

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“…Widely used natural antibacterial agents are under long-term exploration, including chitosan, antibacterial peptides, and other biological extracts [ 52 , 72 , 132 ]. Owing to their extensive sources, low toxicity, biocompatibility, and other advantages [ 133 ], natural agents offer a promising option to improve antibacterial materials and solve the problem of antibiotic resistance [ 119 ]. However, their antibacterial persistence is a major limitation to their application.…”

Section: Natural Antibacterial Agents-incorporated Hydrogelsmentioning

confidence: 99%

Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

Hui-yuan

Lin

et al. 2022

Materials Today Bio

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“…As shown in Figure 2(d), the absorbance of DPG increases linearly with the increase of HP-β-CD concentration, which indicates the existence of host-guest interactions between DPG and HP-β-CD. Assuming that the molar ratio of DPG to HP-β-CD is 1 : 1 or 1 : 2, the following equations are used for calculation [40,41].…”

Section: Research On Dpg-hp-β-cdmentioning

confidence: 99%

Design Strategy for Vulcanization Accelerator of Diphenylguanidine/Cyclodextrin Inclusion Complex for Natural Rubber Latex Foam with Enhancing Performance

et al. 2022

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Vulcanization is an essential process to obtain high-performance rubber products. Diphenylguanidine (DPG) is often used as the secondary accelerator in the vulcanization process of natural rubber (NR) latex. However, DPG would make NR latex emulsion exhibit gelation, resulting in the negative vulcanization efficiency. In addition, exposure to DPG might lead to some physiological diseases during the production process of DPG doped NR latex. Hydroxypropyl-β-cyclodextrin (HP-β-CD) with the hydrophobic interior and hydrophilic exterior has the advantages of good water solubility, high bioavailability, reliable stability, and low toxicity. In this study, the inclusion complex of diphenylguanidine-hydroxypropyl-β-cyclodextrin (DPG-HP-β-CD) is prepared by ball milling with a host-guest molar ratio of 1 : 1, which has also been applied to the foaming process of NR latex. The mechanical properties of DPG-HP-β-CD inclusion complex/natural rubber latex foam (DPG-HP-β-CD/NRLF) have been significantly improved, including the tensile strength, elongation at break, hardness, compression set, resilience, and antiaging performance. Further, the usage of DPG has been reduced, leading to the reduction of toxicity and environmental hazards.

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Study of a water-soluble supramolecular complex of curcumin and β-cyclodextrin polymer with electrochemical property and potential anti-cancer activity

Cited by 37 publications

References 48 publications

Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

Design Strategy for Vulcanization Accelerator of Diphenylguanidine/Cyclodextrin Inclusion Complex for Natural Rubber Latex Foam with Enhancing Performance

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