The α-cluster structure of F isotopes has been studied based on antisymmetrized molecular dynamics. By using the constraint on the principal quantum number, various neutron configurations are investigated. It is found that a proton excitation into an sd shell does not necessarily induce α clustering in 21 F and 23 F. However, once one or two neutrons are excited into the pf shell together with a proton excitation, the core nuclei have α clustering. The calculation is extended toward the neutron drip line. The neutron-rich F isotopes also have α clustering in the excited states and their excitation energy greatly decreases toward the neutron drip line. The relation between the reduction of their excitation energies and the breaking of the neutron magic number N = 20 is suggested.