Study of 1,4-Dioxane Intake in the Total Diet Using the Market-Basket Method

Nishimura, Takuya; Iizuka, Seiichiro; Kibune, Nobuyuki; Ando, Masayuki

doi:10.1248/jhs.50.101

Cited by 10 publications

(8 citation statements)

References 7 publications

(11 reference statements)

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“…The recovery rate of 0.2 µg of 1,4-dioxane was between 99 and 111% in the 12 food groups. 1) These results indicate that extraction of the compound from any food was efficient and met the requirements for this study.…”

Section: Recovery Test Of 14-dioxanesupporting

confidence: 56%

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Study of 1,4-Dioxane Intake in the Total Diet

Nishimura

Iizuka

Kibune

et al. 2005

JOURNAL OF HEALTH SCIENCE

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1,4-Dioxane is a newly added compound to the water quality standards in Japan that were revised in 2003. In order to estimate the contribution of 1,4-dioxane in drinking water to the total exposure in humans, it is necessary to take into account the quantity of the compound in food. In an earlier study, we measured the intake of 1,4-dioxane in food based on the average consumption of food in the Kanto area.1) The total daily intake of 1,4-dioxane was calculated to be 0.440 g. In the present study, we investigated the intake of 1,4-dioxane from food by sampling meals from 3 days from 3 homes in 9 prefectures, respectively. 1,4-Dioxane was extracted from 20 g of homogenates of mixed meals using the steam distillation, concentrated by a solid phase cartridge and then measured using gas-chromatography/mass spectrometry. The detection limit of the analysis was 2 g/kg. No 1,4-dioxane was detected in 26 samples, while 3 g/kg was detected in one sample. In this sample case, the daily intake of the 1,4-dioxane was calculated as 4.5 g that represented 0.56% of the total daily intake (TDI) (4.5 g/{16 g/ kg body weight/day ؋ 50 kg}).

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Section: Recovery Test Of 14-dioxanesupporting

confidence: 56%

“…× 1.4-µm film thickness) (SigmaAldrich Co., Ltd.), as reported previously. 1) In the selected ion monitoring (SIM) mode, the monitoring ions were 58 and 88 for 1,4-dioxane and 64 and 96 for 1,4-dioxane-d 8 . A calibration curve was prepared from the ratio of the peak height of 1,4-dioxane and 1,4-dioxane-d 8 .…”

Section: )mentioning

confidence: 99%

Study of 1,4-Dioxane Intake in the Total Diet

Nishimura

Iizuka

Kibune

et al. 2005

JOURNAL OF HEALTH SCIENCE

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“…: +81-48-458-6263; Fax: +81-48-458-6270; E-mail: sugiyama@niph.go.jp performed in Japan. [1][2][3][4] In addition to these substances, it is important to investigate the intakes of radionuclides, considering them to be toxic substances, and evaluate the dietary exposure doses based on the values obtained. Studies concerning the daily intakes of radionuclides by the public have been performed in many countries, [5][6][7][8][9][10][11][12][13][14][15][16] and the nuclides investigated were natural radionuclides, such as 238 U and 232 Th, in many reports.…”

Section: Introductionmentioning

confidence: 99%

Contents and Daily Intakes of Gamma-Ray Emitting Nuclides, 90Sr, and 238U using Market-Basket Studies in Japan

Sugiyama

Terada

Takahashi

et al. 2007

JOURNAL OF HEALTH SCIENCE

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To investigate the contents of radionuclides in foods marketed in Japan and their daily intakes and exposure doses in adults, we performed market-basket studies concerning radionuclide intakes. The study period was [2003][2004][2005], and the studies were performed in 13 cities in Japan. Foods including drinking water were divided into 14 food groups, and samples were prepared by common cooking procedures. γ-ray emitting nuclides (an artificial radionuclide, radioactive Cs, and natural radionuclides, 40 K and U series such as 214 Bi, and 212 Pb, and Th series) were measured in each food group, and artificial radionuclides, 90 Sr and 238 U, were measured in a mixed sample of 13 food groups excluding drinking water. The daily intakes in adults were calculated from the concentrations of the radionuclides and mean daily consumption of foods and drinking water. The daily 137 Cs and 40 K intakes (mBq/ person · day) in the 13 cities were 12.5-<79.7 and 57309-95746, respectively. The 90 Sr intake from the food groups excluding drinking water was 20.8-53.6, with a mean of 39.2 (mBq/person · day) (deviation of the mean: 23%). Similarly, the daily 238 U intake was 5.9-31.1, with a mean of 12.6 (mBq/person · day) (deviation: 60%), showing a more than 5-fold difference between the minimum and maximum values, and there were regional differences. Since the contents of the U series, such as 214 Bi and 212 Pb, and Th series were lower than the lower detection limits in many samples, their daily intakes were not calculated. Regarding the daily intake of 137 Cs from each food group, the intakes from fish and shellfish, milk, meat/eggs, and mushrooms/seaweed tended to be higher. The daily 40 K intake from each food group varied among the areas, but the total intake from the 14 food groups was similar in all 13 cities. 40 K from these foods accounted for most of the annual effective dose (µSv/person · year) of γ-ray emitting nuclides, and the doses of 40 K, 90 Sr, and 238 U were 130-217, 0.21-0.55, and 0.10-0.51, respectively.Key words --radionuclide, intake, dose estimation, diet, cesium INTRODUCTIONClarification of the contents and distribution of toxic substances in foods, and estimation and evaluation of their intakes by the public are important to secure food safety. For this purpose, studies concerning dietary intakes of chemical substances, such as Polychlorinated Biphenyl (PCB) and dioxin, and toxic elements, such as Cd, Pb, and As, have been * To whom correspondence should be addressed: Department of Environmental Health, National Institute of Public Health, 2-3-6, Minami, Wako-shi, Saitama 351-0197, Japan. Tel.: +81-48-458-6263; Fax: +81-48-458-6270; E-mail: sugiyama@niph.go.jp performed in Japan. [1][2][3][4] In addition to these substances, it is important to investigate the intakes of radionuclides, considering them to be toxic substances, and evaluate the dietary exposure doses based on the values obtained. Studies concerning the daily intakes of radionuclides by the public have been performed in many countries, [5]...

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“…1,4‐Dioxane also was found in almost all foods tested by Nishimura et al (). The 1,4‐dioxane content varied between 2 and 15 μg/kg, with dairy products containing the highest concentrations.…”

Section: Occurrencementioning

confidence: 68%

“…Taking the different amounts of food typically consumed per day into account, the average 1,4‐dioxane uptake was 0.440 μg/person/day. This is several orders of magnitude lower than the tolerable daily intake (TDI) of 16 μg/kg body weight (BW) that was calculated at that time for the cancer endpoint (Nishimura et al ). The maximum concentration found in food is on the same order of magnitude as the World Health Organization (WHO) guideline value for drinking water at 50 μg/L (WHO ).…”

Section: Occurrencementioning

confidence: 84%