Study for quantitative evaluation of liver volume and accumulation rate of radioactive agent with single photon emission computed tomography.

Sato, Shizou; Mimura, Hisashi; Noda, Takuo; Orita, Kunzo; Hiraki, Yoshio; Awai, Sachio; Nagaya, Isao; Aono, Kaname

doi:10.3769/radioisotopes.36.6_265

RADIOISOTOPES

1987

DOI: 10.3769/radioisotopes.36.6_265

|View full text |Cite

Study for quantitative evaluation of liver volume and accumulation rate of radioactive agent with single photon emission computed tomography.

Shizou Sato¹,

Hisashi Mimura²,

Takuo Noda³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1998

2013

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…79 Typically, a cut-off value of 35-39% is employed for delineating the liver. 79,81 Although static SPECT has the ability to visualize regional differences in liver function, functional liver volume measured by the outline extraction method, does not take into account the regional functional differences within the delineated liver volume. 74 As an alternative to static SPECT, dynamic SPECT has been employed to measure the uptake dynamics of 99m Tc-GSA in a 3-dimensional manner using a rapidly rotating, multidetector gamma camera.…”

mentioning

confidence: 99%

Physiological and Biochemical Basis of Clinical Liver Function Tests

et al. 2013

View full text Add to dashboard Cite

Because of the complexity of liver function, one single test does not represent overall liver function. In addition to computed tomography volumetry, quantitative liver function tests should be used to determine whether a safe resection can be performed. Presently, (99m)Tc-mebrofenin hepatobiliary scintigraphy seems to be the most valuable quantitative liver function test, as it can measure multiple aspects of liver function in, specifically, the future remnant liver.

show abstract

mentioning

confidence: 99%

Physiological and Biochemical Basis of Clinical Liver Function Tests

et al. 2013

View full text Add to dashboard Cite

show abstract

Preoperative evaluation of hepatic functional reserve following hepatectomy by technetium-99m galactosyl human serum albumin liver scintigraphy and computed tomography

Mitsumori

Nagaya

Kimoto

et al. 1998

European Journal of Nuclear Medicine and Molecular Imaging

View full text Add to dashboard Cite

It is extremely important to have a good grasp of the acceptable limit of hepatectomy before operation because postoperative liver failure can take a fatal course; however, baseline data on the limit of hepatectomy have not been clearly defined. We therefore evaluated and compared the predicted remnant liver function obtained by computed tomography(CT) and technetium-99m diethylenetriamine penta-acetic acid-galactosyl human serum albumin (99mTc-GSA) liver scintigraphy in order to obtain precise data regarding remnant liver function before hepatectomy. We investigated 20 patients undergoing hepatectomy using the clearance rate of indocyanine green (KICG) as a parameter, and compared the predicted postoperative KICG obtained by CT and by transaxial single-photon emission tomographic (SPET) images acquired by 99mTc GSA liver scintigraphy before hepatectomy. In GSA studies, based on time-activity curves for the heart and liver, we compared HH15 (heart activity at 15 min divided by heart activity at 3 min), LHL15 (liver activity at 15 min divided by heart plus liver activity at 15 min) and KL (obtained from the time-activity curve for the liver) in 103 patients. In 58 patients without increased serum bilirubin, KL was compared with KICG. In four patients, occlusion of the right portal vein was performed with the aim of carrying out secondary hepatectomy, and changes in liver volume were compared between CT and 99mTc GSA liver scintigraphy. The correlation coefficient between the postoperative KICG predicted by CT and the actual postoperative KICG was rather poor, at r = 0.569 (P < 0.05); that between the postoperative KICG predicted by 99mTc GSA liver scintigraphy and the actual postoperative KICG was good, at r = 0.788 (P < 0.01); correlations between KL and HH15 and between KL and LHL15 in 103 patients were very good or good, at r = 0.906 (P < 0.001) and r = 0.807 (P < 0.001), respectively, and that between KL and KICG in 58 patients was very good, at r = 0.916 (P < 0.001). In all four cases of right portal vein occlusion, the remnant liver volume ratio was markedly increased after occlusion in GSA compared with CT, and the postoperative KICG predicted by GSA after occlusion was closer to the actual postoperative KICG than that predicted by CT. It is concluded that 99mTc GSA liver scintigraphy is useful for predicting remnant liver function before hepatectomy and for evaluating changes in regional liver function after occlusion of the portal vein unilaterally.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Study for quantitative evaluation of liver volume and accumulation rate of radioactive agent with single photon emission computed tomography.

Cited by 2 publications

References 0 publications

Physiological and Biochemical Basis of Clinical Liver Function Tests

Physiological and Biochemical Basis of Clinical Liver Function Tests

Preoperative evaluation of hepatic functional reserve following hepatectomy by technetium-99m galactosyl human serum albumin liver scintigraphy and computed tomography

Contact Info

Product

Resources

About