Study and Synthesis of Biologically Active Phenothiazines, their Sulfones, and Ribofuranosides

Khandelwal, Nishidha; Yadav, Abhilasha; Gautam, Naveen; Gautam, D. C.

doi:10.1080/15257770.2012.719657

Cited by 6 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be noted that sulfone derivatives of 10H-phenothiazines exhibit better antimicrobial activities than their parent compounds. [34][35][36][37][38] This finding can be explained by the presence of the electron withdrawing group (-SO 2 ) in sulfones, which enhances biological activity. This effect of an electronwithdrawing group has been noted in the literature.…”

Section: Synthesis Of 1-nitro-10h-phenothiazine-55-dioxides (Sulfonementioning

confidence: 89%

Antioxidant and Antimicrobial Assessment of Synthesized and Spectrally Characterized New Nitrophenothiazines and their Sulfone Analogues

Gautam

Garg

Bishnoi

et al. 2015

Phosphorus, Sulfur, and Silicon and the Related Elements

Self Cite

View full text Add to dashboard Cite

30% H 2 O 2 glacial AcOHSulfones 4a-e 2-Aminobenzenethiols Smiles rearrangementAbstract A series of new nitrophenothiazines and their sulfones were synthesized and their in vitro antimicrobial assessment was carried out against a representative panel of gram positive and gram negative bacterial strains and selected fungi species. The synthesized compounds were screened for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ) radical cation decolorization assay. Structural determination was carried out by spectral and elemental investigations.

show abstract

Section: Synthesis Of 1-nitro-10h-phenothiazine-55-dioxides (Sulfonementioning

confidence: 89%

Antioxidant and Antimicrobial Assessment of Synthesized and Spectrally Characterized New Nitrophenothiazines and their Sulfone Analogues

Gautam

Garg

Bishnoi

et al. 2015

Phosphorus, Sulfur, and Silicon and the Related Elements

Self Cite

View full text Add to dashboard Cite

show abstract

“…After incubation the growth inhibiting zones around the disc was observed. Growth inhibiting zone indicates that the compounds inhibit growth of microorganism [22][23][24] .…”

Section: Antifungal Activitymentioning

confidence: 99%

Untitled

2015

IJPSR

View full text Add to dashboard Cite

In recent years, synthesis and biological evaluation of novel 4H-1, 4-benzothiazines and their sulfone analogues have gained momentum due to their medicinal and industrial importance. The present article describes the synthesis of new 4H-1, 4-benzothiazines via condensation and oxidative cyclization of substituted 2-aminobenzenethiols with compounds containing active methylene groups. It is believed that the reaction proceeds via intermediary of the enaminoketone system. The sulfone derivatives were synthesized by oxidation of 4H-1, 4-benzothiazines using 30% hydrogen peroxide in glacial acetic acid. The structures of the compounds have been confirmed by spectral and chemical analysis. The synthesized compounds were screened for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ) radical cation decolorization assay. The in vitro antibacterial activity was tested against S. aureus, B. subtilis (Gram positive) and E. coli, Pseudomonas aeruginosa (Gram negative) microorganisms using paper disc diffusion method using nutrient agar medium and the antifungal activity of synthesized compounds was tested on fungal strains: A. niger, C. albicans using disc diffusion method.

show abstract

“…Minimum inhibition concentration (MIC) is the lowest concentration of test compound which have been screened for their antimicrobial (antibacterial and antifungal) activity. 16,17 At this lowest concentration of test compounds, appears the inhibition of visible growth of bacteria and fungi after 22-24 h, incubation at 37 • C. The determination of the MIC involves a semi quantitative test procedure, which gives an approximation to the least concentration of an antimicrobial (test solution) needed to parent microbial growth. The MIC was determined by the liquid dilution method.…”

Section: 1a Minimum Inhibitory Concentrationsmentioning

confidence: 99%

Synthesis and evaluation of antimicrobial and anthelmintic activity of novel fluorinated 7-ethyl-10H-phenothiazines, their sulphones and ribofuranosides

Gautam¹,

Yadav

Khandelwal

et al. 2014

J Chem Sci

Self Cite

View full text Add to dashboard Cite

A series of novel fluorinated 10H-phenothiazines were synthesized via Smiles rearrangement. 10H-phenothiazines on refluxing with 30% hydrogen peroxide in glacial acetic acid gave 10H-phenothiazines-5, 5-dioxides (sulphones). These synthesized 10H-phenothiazines were then used as base to prepare ribofuranosides by treating them with sugar (β-D-ribofuranosyl-1-acetate-2, 3, 5-tribenzoate). The synthesized compounds were screened for antimicrobial activity and anthelmintic activity. The structural assignments of compounds were made on the basis of spectroscopic data and elemental analysis.

show abstract

Study and Synthesis of Biologically Active Phenothiazines, their Sulfones, and Ribofuranosides

Cited by 6 publications

References 12 publications

Antioxidant and Antimicrobial Assessment of Synthesized and Spectrally Characterized New Nitrophenothiazines and their Sulfone Analogues

Antioxidant and Antimicrobial Assessment of Synthesized and Spectrally Characterized New Nitrophenothiazines and their Sulfone Analogues

Untitled

Synthesis and evaluation of antimicrobial and anthelmintic activity of novel fluorinated 7-ethyl-10H-phenothiazines, their sulphones and ribofuranosides

Contact Info

Product

Resources

About