Study and formation of vesicle systems with low polydispersity index by ultrasound method

Pereira-Lachataignerais, J.; Pons, Ramón; Panizza, Pascal; Courbin, Laurent; Rouch, J.; López, Olga

doi:10.1016/j.chemphyslip.2006.01.008

Cited by 101 publications

(71 citation statements)

References 22 publications

(25 reference statements)

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“…Size (hydrodynamic diameter), Polydispersity index (PDI) and zeta potential of particles are parameters that indicate the stability of nanoparticles (40)(41). High PDI indicates the heterogeneity of the particle size in suspension.…”

Section: Insert Figure 2 Herementioning

confidence: 99%

“…While smaller PDI values indicate the homogeneity of the particle size in suspension. It was reported that PDI lower than 0.2 is considered to be ideal hence, the particle size distribution falls within a narrow range of size (40,(42)(43)(44)(45). The surface charge also plays an important role in the stability of the nanoparticles and the magnitude of zeta potential is indicative of the colloidal stability of the system (46).…”

Section: Insert Figure 2 Herementioning

confidence: 99%

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Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors

Abdellatif

Zayed

Elbakry

et al. 2016

Drug Development and Industrial Pharmacy

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confidence: 99%

Section: Insert Figure 2 Herementioning

confidence: 99%

Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors

Abdellatif

Zayed

Elbakry

et al. 2016

Drug Development and Industrial Pharmacy

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“…One important parameter of nanoparticles is the polydispersity index (PDI), which is measured the particle size distribution. If PDI is smaller than 0.1, the particles are typically referred to as "monodisperse" (Moreira, Gaspar, Allen, 2001;Pereira-Lachataignerais et al, 2006;Pham et al, 2015). Our particles of phytosome curcumin are shown to be The index used to evaluate the stability of particle system is zeta potential value.…”

Section: Particles Size and Zeta Potential Of Phytosome Curcuminmentioning

confidence: 99%

Hepatoprotective effect of Phytosome Curcumin against paracetamol-induced liver toxicity in mice

Tùng¹,

Hải

Phan

2017

Braz. J. Pharm. Sci.

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Curcuma longa, which contains curcumin as a major constituent, has been shown many pharmacological effects, but it is limited using in clinical due to low bioavailability. In this study, we developed a phytosome curcumin formulation and evaluated the hepatoprotective effect of phytosome curcumin on paracetamol induced liver damage in mice. Phytosome curcumin (equivalent to curcumin 100 and 200 mg/kg body weight) and curcumin (200 mg/kg body weight) were given by gastrically and toxicity was induced by paracetamol (500 mg/kg) during 7 days. On the final day animals were sacrificed and liver function markers (ALT, AST), hepatic antioxidants (SOD, CAT and GPx) and lipid peroxidation in liver homogenate were estimated. Our data showed that phytosome has stronger hepatoprotective effect compared to curcumin-free. Administration of phytosome curcumin effectively suppressed paracetamol-induced liver injury evidenced by a reduction of lipid peroxidation level, and elevated enzymatic antioxidant activities of superoxide dismutase, catalase, glutathione peroxidase in mice liver tissue. Our study suggests that phytosome curcumin has strong antioxidant activity and potential hepatoprotective effects.Uniterms: Curcumin/effects. Curcumin/antioxidant activity. Curcuma longa. Phytosome. Hepatoprotective.

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“…PDI is a measure of the distribution of molecular mass in a given polymer sample an also index that could indicate of the stability of the LOR-GNPs since it represents the particles distribution in colloidal solution. High PDI values indicates the heterogeneity of the particle size in suspension, while smaller PDI indicate the homogeneity of the particle size in suspension, ideally the value of PDI should be ˂0.7 because they indicate a particle size distribution falls within a narrow range of sizes [22,[25][26][27][28]. In the present study the PDI average value of ≈ 0.3 ± 0.02 was recorded for the formulated GNPs-LOR which revealed the homogeneity of the particle size in the obtained suspension.…”

Section: Resultsmentioning

confidence: 99%

“…The solution initially, is clear and colorless then changed into cloudy solution indicated that the solution containing highly dispersed nanoparticles containing LOR-glycerin. Desirable size, zeta potential, PDI and adjusting the surface charge are parameters that indicate the colloidal stability of the obtained nanoparticles system [13][14][22][23][24].…”

Section: Resultsmentioning

confidence: 99%

Formulation of Novel Glycerin Nanoparticles for Enhancement the Solubility of Loratadine; Application to Transdermal Hydrogel Delivery System

Abou-Taleba¹,

Hamdb²,

Abdellatif³

2017

J Nanomed Nanotechnol

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Owing to its slightly aqueous solubility, loratadine (LOR) is used in high doses in different marketed formulations to achieve its desirable bioavailability. The aim of this work is to formulate novel LOR-glycerin nanoparticles (LOR-GNPs) to increase LOR bioavailability. LOR-GNPs were prepared by a precipitation method and then evaluated for such size and morphology using dynamic scattering spectroscopy (DLS) and scanning electron microscopy (SEM), as well as the percentage entrapment efficiency (EE%) of free LOR from GNPs formulations was performed using titration method. Furthermore, the GNPs were formulated in hydrogel. The hydrogel viscosity, spreadability, homogeneity and abdominal rat skin permeation were studied and optimized DLS indicated a successful coating of LOR with glycerin surface that recorded an average size of 334 ± 30 nm with uniform particle size, while SEM showed LOR-NPs in different shapes. The EE% free LOR was found to be satisfactory with a mean content of 98.1 ± 0.3 and a relative standard deviation below 2.0% indicates the reproducibility of the LOR release. LOR-GNPs were formulated as a hydrogel to check their suitability for a dosage form usage. The hydrogel showed accepted viscosity, spreadability, and homogeneity. The results proved that the GNPs penetrated abdominal rat skin. The obtained results showed that LOR-GNPs are considered a new addition for improvement of LOR solubility when applied as a hydrogel. The developed method could be used for different insoluble candidates.

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Study and formation of vesicle systems with low polydispersity index by ultrasound method

Cited by 101 publications

References 22 publications

Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors

Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors

Hepatoprotective effect of Phytosome Curcumin against paracetamol-induced liver toxicity in mice

Formulation of Novel Glycerin Nanoparticles for Enhancement the Solubility of Loratadine; Application to Transdermal Hydrogel Delivery System

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