Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors

Abdellatif, Ahmed A. H.; Zayed, Gamal; Elbakry, Asmaa M.; Zaky, Alaa A.; Saleem, Imran; Tawfeek, Hesham M.

doi:10.3109/03639045.2016.1173052

Cited by 48 publications

(45 citation statements)

References 63 publications

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“…Somatostatin was also attached to AuNPs to establish a targeted delivery system for antitumor agents. 251 Investigation on HCC-1806 cell lines revealed that cellular uptake of AuNPs-SST was higher than citrate-AuNPs and can be suppressed upon addition of antagonist, suggesting the modification of AuNPs using SST could enhance drug internalization by HCC-1806 cells through the specific interaction between SST and SSTR.…”

mentioning

confidence: 99%

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Li¹,

Zhang²,

Wang³

et al. 2016

IJN

117

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mentioning

confidence: 99%

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Li¹,

Zhang²,

Wang³

et al. 2016

IJN

117

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“…These characteristics make MS more advantageous over many drug delivery systems such as microcapsules and liposomes [14][15][16]. Moreover, targeting can be improved by altering the physicochemical properties such as size of the formulated NPs [17][18][19][20][21] or by attaching targeting ligand in vitro as well as in vivo [22][23][24][25][26]. Furthermore, the formulated NPs need to be identified using different analytical methods which are a novel approach for cancer targeting [20,25,27].…”

Section: Determination Of Encapsulation Efficiency (Ee)mentioning

confidence: 99%

“…It was reported that the particle size of microparticles was proportional to the dispersed phase viscosities. In such a way, increasing the dispersed phase viscosity resulted in increasing the particle size of microparticles (Table 2) [26][27][28]. 5-FU were prepared previously by another group as MS [39], using the technique W/O/W emulsification method.…”

Section: Drug Loaded Microspongesmentioning

confidence: 99%

Preparation and Evaluation of 5-Fluorouracil Loaded Microsponges for Treatment of Colon Cancer

Othman¹,

Zayed²,

El‐Sokkary³

et al. 2017

J Cancer Sci Ther

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5-Fluorouracil (5-FU) has a wide anticancer activity versus several types of solid tumors. The activity of 5-FU can be improved and its toxicity can be diminished by enhancing the relative specific accumulation in the tumor regions. The aim of this work was to develop Eudragit RS100 based 5-FU microsponges (MS) for treatment of colon cancer. Oil in oil emulsion solvent diffusion method was used for the preparation of 5-FU sustained release Eudragit RS100 MS. MS were characterized for their encapsulation efficiency, production yield, drug polymer interaction and drug release profiles. Shape, surface morphology visualized by scanning electron microscope (SEM) and particle size of MS was investigated using laser light scattering technique and. Eventually, HCT 116 and CACO2 cell lines were used for determination of cell viability by MTT assay. The results showed that all prepared MS were spherical in shape with several pores on their surfaces. The production yield was in (62.76% ±1.06% and 93.80% ± 1.75%), encapsulation efficiency was in (71.80% ± 1.62% and 101.3% ± 2.60%) and particle size was in ( 53.11 µm ± 41.03 nm and 118.12 µm ± 48.21 nm). Fourier transform infrared revealed that there is no chemical interaction between 5-FU and Eudragit RS100. MS loaded 5-FU was more effective than 5-FU itself as shown by cell viability assay. The results demonstrated that 5-FU with Eudragit RS100 was successfully formulated as sustained release manner and could be a substitution delivery method of 5-FU for oral anticancer treatment.represent an important factor to oral as compared to administration intravenously as reported previously [9].Conversely, intravenous administration of 5-FU yields severe systemic toxic effects of gastrointestinal (GIT), blood complaints, and skin diseases, due to the 5-FU cytotoxicity on healthful human cells. Hence, the need to formulate targeted delivery of 5-FU through oral route would not only diminish the exposure of healthy cells to the drug but also provide an efficient and harmless curative effect for colon cancer with a lower dose and reduced duration of therapy [5]. It was reported that the therapeutic effect of 5-FU can be augmented and its harmful effects can be suppressed by the precise accumulation of the anticancer agent in the tumor regions with continued exposure of the cells to this drug [10]. To extend the exposure time of cancer cells to 5-FU, the drug delivery was formulated by incorporation into microsponge formulation.Microsponges (MS) are micro-sized particles with high porosity and unique ability for encapsulation of a wide multiplicity of pharmaceutical active ingredients. MS delivery system is used to target and modify the release of active ingredients from pharmaceutical formulations, enhance the stability and decrease the side effects [11]. MS have high load activity reach up to 90% entrapment efficiency [12], self-sterilizing Citation: Othman MH, Zayed GM, El-Sokkary GH, Ali UF, Abdellatif AAH (2017) Preparation and Evaluation of 5-Fluorouracil Loaded Microsp...

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“…The sampling time was set automatically; three measurements were permitted to perform each 10 sub-runs. All measurements were carried out in alcoholic solution [13][14][15][16][17].…”

Section: Characterization Of Developed Spray Formulationsmentioning

confidence: 99%

A Novel Topical Spray Formulation for Ginkgo Bioloba for Antifungal Activity

Aah¹

2016

J Nanomed Nanotechnol

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The aim of this study is to prove the antifungal and antibacterial activity of Ginko biloba GKB from glycerin nanocapsules and nanoemulsions. GKB was formulated as spray formulation for topical application using ethyl alcohol 95%/glycerol/water based formulations. GKB spray was evaluated for their particle size distribution, pH, content uniformity, content per spray, in vitro release and antifungal activity. The antifungal activity was determined by Agar welldiffusion method. The formulae were tested for their skin permeation and the stability of the formulations. The results showed uniform formulae with nano-sized particles, pH compatible with the topical formulation and higher drug content. Diffusion studies of the optimized formulations through the abdominal rabbit skin showed higher penetrated drug over a period of 24 h. Stability studies indicated that formulations were stable. Skin irritation studies confirmed the compatibility of spray formulae with skin. Agar well-diffusion method showed that GKB was effective compared with fluconazole. The inhibition zones for all formulae were significant as compared with standard fluconazole. The results obtained showed that the topical spray formulation could be a promising and innovative therapeutic system as topical antifungal for the transdermal administration of GKB. The developed formulation can be used for delivery from spray formulation. This study proved the local activity of GKB as antifungal drugs.

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Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors

Cited by 48 publications

References 63 publications

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Preparation and Evaluation of 5-Fluorouracil Loaded Microsponges for Treatment of Colon Cancer

A Novel Topical Spray Formulation for Ginkgo Bioloba for Antifungal Activity

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