Study and evaluation antioxidant activity of dietary supplements with green tea extract

Maslov, O. Yu.; Kolisnyk, S. V.; Komisarenko, M. A.; Altukhov, A. A.; Dynnyk, K. V.; Stepanenko, V.I.

doi:10.14739/2409-2932.2021.2.233306

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…According to the results of the study, it was found that the antioxidant activity of the tablets "Сaсhisept" was more than 54 % than the reference drug "Ascorutin". Accord ing to the developed conditional Maslov's classification of the level of antioxidant activity [15], we determined that "Сaсhisept" tablets have a high level of antioxidant activity, and, in turn, the reference drug "Askorutin" has a medium level (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Maslov,

Komisarenko,

Ponomarenko

et al. 2023

CIPM

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Dental caries stands as a highly common chronic ailment affecting individuals globally, with susceptibility to this condition spanning their entire lifespan. Consequently, the search for novel medications aimed at treating and preventing dental caries holds significant importance in the field of pharmacy. The aim of the work was to study the antioxidant, antimicrobial, and antifungal activity of the obtained oral tablets “Сaсhisept” for resorption in the oral cavity for the treatment and prevention of dental caries. Materials and methods. The obtained tablets “Сaсhisept” with green tea leaf extract were the object of investigation. Antioxidant activity was established by the potentiometric method, and antimicrobial and antifungal activity was assessed by the agar well diffusion method. Results. The level of antioxidant activity for tablets “Сaсhisept” was 110.00 ± 2.20 mmol-eqv./mdry res, the obtained tablets had a high level of antioxidant activity according to Maslov’s conditional classification. Staphylococcus aureus (25.33 ± 0.50 mm), Baсillus subtilis (25.33 ± 0.50 mm) and Streptococcus mutans (25.33 ± 0.50 mm) were the most sensitive to the obtained “Сaсhisept” tablets, and the least – Proteus vulgaris (20.67 ± 0.50 mm), and it was observed strong growth inhibition in relation to the fungus Candida albicans (20.00 ± 0.50 mm). Conclusions. The presented study has found that “Сaсhisept” tablets have a high level of antioxidant activity, and also have a high antimicrobial and antifungal effect against all investigated Gram-positive, Gram-negative bacteria, and the Candida albicans fungus. Thus, “Сaсhisept” tablets can be recommended for the treatment and prevention of dental caries.

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Section: Resultsmentioning

confidence: 99%

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Maslov,

Komisarenko,

Ponomarenko

et al. 2023

CIPM

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“…Compared to our study the total catechin content is much higher. Flavonoids is one of the biggest class of biological active substances in plant, it plays an essential role in scavenging free radicals [33]. The total flavonoid content was expressed in rutin equivalent.…”

Section: Resultsmentioning

confidence: 99%

Study of total antioxidant activity of green tea leaves (Camellia sinensis L.)

et al. 2022

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Summary Introduction: There is a high interest in creating medicines, dietary supplements, cosmetics including plant extract with antioxidant activity. For understanding whether plant extract has a maximum level of antioxidant activity it is important to know the total antioxidant activity of raw material. Objective: The main goal of study was to find out the green tea leaves total antioxidant activity. Methods: The antioxidant activity was measured by potentiometric method. Total phenolic, flavonoids, catechins and hydrocinnamic acids derivatives were quantified using Folin-Ciocalteu, aluminium chloride, vanillin and sodium molibdate methods, respectively. Results: The green tea leaves total antioxidant activity was 660.75 mmol-eqv./mres. dry weight. A significant correlation was observed between the amount of phytochemicals and antioxidant activity, which indicated its main role in antioxidant activity. Conclusion: The research showed that the green rea leaves possess a high value of antioxidant activity and it is a good source of phenolic constituents.

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“…In this study, we chose to apply the potentiometric method, as it is characterized by high sensitivity, rapid analysis procedure and relatively low equipment and reagents cost, and, hence, cost of analysis as a whole [33]. Based on our recent study, in determining antioxidant activity of natural antioxidants by the potentiometric method, the ethanol that was used as solvent contributed to the level of antioxidant activity of the analyzed sample.…”

Section: Discussionmentioning

confidence: 99%

Investigation the influence of biologically active compounds on the antioxidant, antibacterial and anti-inflammatory activities of red raspberry (Rubus idaeous l.) leaf extract

Maslov

Komisarenko

Ponomarenko³

et al. 2022

Current Issues in Pharmacy and Medical Sciences

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The aim of the study. To determine phenolic and organic acids compound profiles, and the antioxidant, antibacterial and anti-inflammatory activities of raspberry leaf extract. Materials and methods. The object of the study was red raspberry leaf extract. The quantity of phenolic compounds was determined by applying a spectrophotometric method of analysis, whereas organic acids content was assessed by means of the alkalimetric method, while the antioxidant activity of the obtained extract was evaluated by employing the potentiometric method, and antibacterial and antifungal activity was ascertained through the wells method, and anti-inflammatory activity was found via carrageenan – induced paw edema assay. Results. The content of phenolic compounds was 18.45±0.37 mg/ml, catechins was 10.12±0.20 mg/ml, flavonoids was 3.32±0.07 mg/ml, hydroxycinnamic acids derivatives was 2.39±0.05 mg/ml and organic acids was 7.25±0.15 mg/ml. Moreover, the antioxidant activity was 76.11±1.48 mmol-equiv./mres dry, which was higher by 32.80% than the reference drug „Ascorutin”. Staphylococcus aureus bacteria was the most sensitive to the extract (25.00±0.00 mm), whereas Pseudomonas aeruginosa was the most resistant (21.67 ±0.66 mm). Treatment with red raspberry leaf extract at 1 ml/kg showed a significant edema reduction at 1, 2 and 3 h at 38.8, 41.8 and 48.8%, compared with the saline group. Conclusian. The present study indicated that red raspberry leaf extract possesses antioxidant, antibacterial and anti-inflammatory activities. Thus, red raspberry leaves are a promising source of bioactive substances that can be used for further developing medicines in the treatment and prevention of lifestyle diseases.

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Study and evaluation antioxidant activity of dietary supplements with green tea extract

Cited by 7 publications

References 9 publications

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Study of total antioxidant activity of green tea leaves (Camellia sinensis L.)

Investigation the influence of biologically active compounds on the antioxidant, antibacterial and anti-inflammatory activities of red raspberry (Rubus idaeous l.) leaf extract

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