Study and development of microemulsion formulations to increase the permeability of acyclovir

Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants

“…The increased viscosity of the systems turns important as far as its external use is concerned. These demands are to a large extent met in the case of microemulsions, which usually consist of aqueous and oil (hydrocarbon) phases separated by a layer of micelle-forming surfactant, sometimes in the presence of a co-surfactant [5][6][7]. Nonionic surfactants, which are low-toxic and compatible with many biologically active species, have been often used in the preparation of microemulsions intended for biomedical applications [8][9][10].…”