Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants

The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving the solubility of hydrophobic bioactives. Further, liposomal vehicles are reviewed, with both advantages and limitations discussed. Literature assay covers up-to-date information of about last three to five years, although brief background is given on the pioneer works addressing the liposomes and their evolution from bench to bedside. Final part of the review is devoted to the modern modifications of vesicular nanocarriers which can be adapted to specific administration way due to improved targeting properties, permeability, mucoadhesiveness and possibility to cross biological barriers. Therein, such kinds of nanocarriers as transfersomes, niosomes, ethosomes, chitosomes are evaluated; and separate sections focus on the natural based formulations, i.e., phytosomes and invasomes.

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Development of a complex of doxorubicin with nanoparticles based on sodium alginate and viologen calix[4]resorcinol to increase selectivity of cytotoxic action

Kashapov,

Razuvaeva,

Ziganshina

et al. 2023

Žurnal obŝej himii

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A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) was obtained. Using a set of physicochemical methods, the polymer- macrocycle ratio was found, at which stable nanoparticles are formed, and their morphological characteristics were determined. It was shown that with an increase in the concentration of calix[4]resorcinol, the size of nanoparticles increases and the zeta potential changes from negative to positive values. It was established that the most optimal supramolecular system for DOX binding is a composition with a macrocycle-polymer ratio of 1:50, and a change in the ratio of components can initiate drug release. The effect of encapsulated DOX on the physicochemical and biological properties of the supramolecular system was shown.

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Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants

Cited by 3 publications

References 28 publications

Development of Doxorubicin Complex with Nanoparticles Based on Sodium Alginate and Viologen Calix[4]resorcinol to Enhance Selectivity of the Cytotoxic Action

Development of Doxorubicin Complex with Nanoparticles Based on Sodium Alginate and Viologen Calix[4]resorcinol to Enhance Selectivity of the Cytotoxic Action

Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Development of a complex of doxorubicin with nanoparticles based on sodium alginate and viologen calix[4]resorcinol to increase selectivity of cytotoxic action

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