Study and comparative evaluation of the toxicity of molybdenum (VI) oxide nanoparticles at a single oral exposure

Abstract

The toxic effect of nanoparticles of molybdenum (VI) oxide (MoO3 NPs) after a single oral intake was studied. We administered the test substance as an aqueous suspension at a dose of 2000 mg/kg body weight. Organs were taken from surviving animals 14 days after exposure to study the bioaccumulation of MoO3 NPs and pathomorphological changes caused by the action of this nanomaterial. On the second day after exposure, the death of 50% of the group exposed to NPs was recorded. It has been established that MoO3 NPs accumulate in the heart, lungs, liver, kidneys and brain in concentrations 15.59-221.86 times higher than the control values. In the liver of exposed rats revealed by histological methods the development of hepatitis and microvesicular steatosis; in the lungs – acute bronchitis, vasculitis; in the brain – subarachnoid hemorrhage. MoO3 NPs have a more apparent ability to bioaccumulate and produce toxic effects in comparison with their microdispersed analogue under single oral introductions into the body.