Study about evaluation of efficacy of methotrexate in localized scleroderma using ultrasonography

Zhang, Fan; Li, Jianke; Zhao, Qing; Liu, Hong; Zhang, Furen

doi:10.1111/srt.13300

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…On longitudinal assessments with US, they found a significant decrease in DT with the average decrease being 69% [ Figure 2 ]. [ 10 ] Although no statistical difference existed between the clinical scoring systems and US measurements, the US measurements were more sensitive as the changes could be detected earlier in response to the treatment with the average first reaction time being 1.8 months. This provides further evidence for the utility of US as a tool to assess therapeutic efficacy.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Utility in the Management of Morphea: A Comprehensive Review

Khan,

Khachemoune

2024

Indian Dermatology Online Journal

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Introduction: Morphea, an autoimmune progressive disorder, can significantly impact patient well-being, yet therapeutic options, though expanding, exhibit limited efficacy. A persistent challenge in disease management revolves around monitoring disease activity and gauging treatment effectiveness. To address this, various clinical assessment tools have been devised, each with its inherent limitations. The realm of imaging in morphea has undergone noteworthy expansion, with ultrasonography (US) emerging as an efficacious and cost-effective avenue for quantifying disease activity and evaluating therapeutic outcomes. However, the evidential support for its application remains equivocal. Our aim was to explore and analyze the existing evidence concerning the utility of ultrasound in the management of morphea. Materials and Methods: We conducted a comprehensive literature review using PubMed Medline to assess evidence concerning US utility in morphea management. Results: Sixteen total studies were included in our review. Discussion: Although the studies presented carry their own limitations, cumulative findings indicate the potential of ultrasound, particularly when coupled with Doppler, in facilitating staging, assessing disease activity, and longitudinal assessment of therapeutic efficacy in patients with morphea.

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Section: Discussionmentioning

confidence: 99%

Ultrasound Utility in the Management of Morphea: A Comprehensive Review

Khan,

Khachemoune

2024

Indian Dermatology Online Journal

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“…[5][6][7] Chen et al, 8 compared the skin thickness measurement by US with the skin biopsy and reported good agreement in patients with scleroderma. Furthermore, Zhang et al 9 Reported the usefulness of US in skin evaluation after treatment with methotrexate in localized scleroderma. There are multiple therapeutic options for morphea.…”

Section: Introductionmentioning

confidence: 99%

Clinical and ultrasonographic evaluation of efficacy and safety of intralesional injection of autologous platelet-rich plasma in morphea: A comparative case series

Elnaquip,

Makki,

Mansour

et al. 2024

Journal of Scleroderma and Related Disorders

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Objective: To evaluate the efficacy and safety of platelet-rich plasma to restore skin changes in morphea by ultrasound and Localized Scleroderma Cutaneous Assessment Tool. Methods: Nine morphea patients (21 lesions) were diagnosed clinically and by histopathology. Intradermal platelet-rich plasma was injected into morphea lesion once weekly for 12 sessions. The disease severity and damage were evaluated at baseline, after the last session (3 months later), and at 6 months follow-up using the LoSCAT and a high-resolution ultrasound. The healthy corresponding side was considered as a control. Results: The Localized Scleroderma Cutaneous Assessment Tool score showed a significant improvement starting from 13 ± 7.28 up to 7.33 ± 6.82 after the therapeutic endpoint, reaching to 6.44 ± 7.09 after 6 months of follow-up with p value = 0.008 and 0.014, respectively. There was a significant positive correlation between the duration of the lesion and the improvement assessed by the ultrasound, with p value = 0.01. Regarding adverse effects, all patients reported having pain during platelet-rich plasma injection; transient edema of the face was reported by four patients (45%), and only two patients showed transient erythema. Conclusion: Autologous platelet-rich plasma is a safe technique with great aesthetic outcomes for filling up the contour defects and correcting both hyper and hypopigmentation, in addition to softening the indurated lesions.

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Study about evaluation of efficacy of methotrexate in localized scleroderma using ultrasonography

Zhang

Zhao

et al. 2023

Skin Research and Technology

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Background:The treatment and curative effect evaluation of localized scleroderma (LS) still perplexes many clinical workers.Purpose: To investigate the efficiacy of methotrexate in the treatment of LS by the evaluation of ultrasonography. Methods: A prospective study enrolled 10 patients treated with MTX for at least 6 months was conducted. Treatment outcome was evaluated by a clinical score and 15-MHz ultrasonography. Safety assessment included the monitoring of adverse drug reactions and clinical laboratory examinations.Results: Eight of the 10 patients achieved clinical remission only with MTX. One patient was relieved after MTX combined with corticosteroids, while another one does not improve after the treatment of mycophenolate mofetil and corticosteroids. The effective rate of MTX is 80%. Nine patients were significantly improved with a decrease of the Localized Scleroderma Cutaneous Assessment Tool (the mean score of the LoSCAT cutaneous activity dropped from 5.2 to 1.0, p < 0.001, the mean score of the LS cutaneous damage dropped from 4.3 to 2.3, p = 0.002). The average difference of thickness between skin lesions and normal skin evaluated by ultrasonography decreased from 0.13 cm to 0.04 cm (p = 0.009) in eight patients. No serious adverse reactions occurred. Conclusion:Methotrexate is a safe and effective treatment for patients with LS.Ultrasonography can be considered as an efficient assessment tool for evaluation LS.

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Study about evaluation of efficacy of methotrexate in localized scleroderma using ultrasonography

Cited by 3 publications

References 29 publications

Ultrasound Utility in the Management of Morphea: A Comprehensive Review

Ultrasound Utility in the Management of Morphea: A Comprehensive Review

Clinical and ultrasonographic evaluation of efficacy and safety of intralesional injection of autologous platelet-rich plasma in morphea: A comparative case series

Study about evaluation of efficacy of methotrexate in localized scleroderma using ultrasonography

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