Studies With Inagglutinable Erythrocyte Counts. V. Spontaneous and X-Ray-Induced Hemolysis in Malignancy 12

Studies of the Anemia and Iron Metabolism in Cancer 1

“…In 5 of 13 studies involving the transfusion of normal red cells into cancer patients the survival of these cells was shortened, their life span ranging from 25 to 80 days, confirming previous observations (4)(5)(6). The hemolytic rate returned to normal in 2 patients, both of whom had widespread metastatic disease and anemia.…”

Studies With Inagglutinable Erythrocyte Counts. Vi. Accelerated Destruction of Normal Adult Erythrocytes in Pernicious Anemia; Contribution of Hemolysis to the Oligocythemia 12

“…This is in decided contrast to the reaction of the hematopoietic system in carcinoma and X radiation (9) and in many other types of hemolytic anemia. Apparently B12 deficiency precludes this "acceleration response" of the bone marrow beyond permitting a normal rate of erythrocyte release.…”

Studies on the Incorporation of 35S Labelled Cystine into the Leucocytes of Tumour Bearing Rats.

“…Only in the last years information was obtained, mostly making use of isotopic techniques, on the mechanism of anemia in cancer. The life span of the erythrocytes has been shown to be shortened in patients suffering from various kinds of malignancies (reviewed by HEVESY 1958) at least to a large extent produced by extrinsic factors (BROWN 1950, DEGOWIN, SHEETS and HAMILTON 1950, HYMAN 1954, SHEETS et al 1954, HYMAN, GELLHORN and HARVEY 1956, MILLER et al 1956, DALSANTO 1957. The shortening of the life span of the erythrocytes is not seldom followed by a formation of red corpuscles a t an increased rate.…”