Studies With Inagglutinable Erythrocyte Counts. Vi. Accelerated Destruction of Normal Adult Erythrocytes in Pernicious Anemia; Contribution of Hemolysis to the Oligocythemia 12

Hamilton, Henry E.; DeGowin, Elmer L.; Sheets, Raymond F.; Janney, Clinton D.; Ellis, Jason A.

doi:10.1172/jci102885

Cited by 28 publications

(5 citation statements)

References 4 publications

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“…In the present series, patients with the lowest serum haptoglobin levels tendcd also to be the most anaemic and to have the highest serum bilirubin levels (ree Results). h i untreated pernicious anaemia, circulatiiig erythrocytes have a rcduccd life-span as has been demonstrated by the Ashby technique (Loutit, 1946;Singer, King and Robin, 1948;Hamilton, DeGowin, Sheets, Janney and Ellis, 1954) and by the radio-chromium method (Jandl, Grcenberg, Yonemoto and Castle, 1956;Finch, Coleman, Motulsky, Doiiohue and Reiff, 1956;Gilbcrtsen, Hawkinson and Watson, 1959). However, there are a iiuinber of factors which indicate that in pernicious anaemia destruction of immature erythrocytes (nuclcatcd crythrocytcs containing haemoglobin or reticulocytes) is quaiititativcly much more important than tlic destruction of mature erythrocytes.…”

Section: Discussionmentioning

confidence: 83%

Serum Haptoglobins in Megaloblastic Anaemia

et al. 1960

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Section: Discussionmentioning

confidence: 83%

Serum Haptoglobins in Megaloblastic Anaemia

et al. 1960

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“…Several observers (18,19) have demonstrated that the life span of cells from a patient with pernicious anemia, transfused into a normal recipient, is moderately impaired. It has been suggested that, in addition to the intracorpuscular defect in this disease, there is an extracorpuscular hemolytic mechanism (27).…”

Section: Discussionmentioning

confidence: 99%

The Kinetics of Iron Metabolism in Swine With Various Experimentally Induced Anemias

Bush

Jensen

Ashenbrucker

et al. 1956

The Journal of Experimental Medicine

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In the preceding publication (1) the results of studies on the kinetics of iron metabolism (2-5) in normal growing swine were reported. The purpose of this paper is to present the results of similar studies in swine with three different types of experimentally induced anemias. As an example of a severe hemolytic process with no detectable impairment in the capacity of the bone marrow to produce erythrocytes, anemia induced by the administration of phenylhydrazine (6) has been studied. The kinetics of iron metabolism have been studied also in swine with anemia due to a deficiency of pyridoxine (6--8) and in swine with anemia due to a deficiency of pteroylglutamic acid (9-11). The last two anemias are quite different morphologically. That anemia associated with pyridoxine deficiency is microcytic and hypochromic, whereas that occurring in pteroylglutamic acid deficiency is macrocytic. In both, the plasma iron level is greatly elevated, there is a reduction in the amount of free protoporphyrin in the erythrocytes, and there is erythroid hyperplasia in the bone marrow. However, the tissues of the pyridoxinedeficient animals are heavily laden with iron, whereas hemosiderin deposits are not prominent in the tissues of swine deficient in pteroylglutamic acid.These studies were carried out in the hope of gaining an understanding of the pathogenesis of the anemia in these conditions and also with the expectation that these anemias of known and singular etiology might serve as patterns of reference for anemias which develop in human subjects. In a later publication (12) iron kinetics will be described in copper-deficient swine. The anemia accompanying that condition is microcytic and hypochromic and the level of iron in the plasma and tissues is low.

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“…has further been clarified in recent years by H a m il t o n et al (14) who demonstrated, in ad dition, an extracorpuscular factor: vitamin B12 deficiency Uself. Evidence for this was given from two observations.…”

Section: Discussionmentioning

confidence: 95%