Studies on wound healing potential of red pigment isolated from marine Bacterium Vibrio sp.

Abstract

Wounds are common clinical entities of life which may be subacute or acute. Wound healing is a complex biochemical process where the cell structures are restored to normalcy, which depend on cell proliferation and migration, basically fibroblast cell. The present investigation was undertaken to evaluate the healing efficacy of red pigment isolated from marine isolate Vibrio sps on experimental wounds in albino rats. The red pigment was applied topically, twice daily for 14 days. Treatment with framycetin ointment was used as reference control. The red pigment treated group showed faster reduction in wound area in comparison with control and framycetin ointment treated groups. In conclusion, red pigment possesses significant healing potential in wounds and has a positive influence on the different phases of wound repair.

Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water

“…Initially plant derivatives were used to use numerous drugs used in conventional medicine ( Oreagba et al, 2011 ). In the recent study, Shiva et al (2019) confirmed faster reduction in wound area from red pigment in comparison with control and framycetin ointment treated groups and indicated that red pigment shown significant wound healing potential with positive influence on wound repair phases.

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Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

“…The dynamic pathogenetic process of the healing of acute wounds depends on the balance of such factors as oxygenation, temperature, and pH [12,[24][25][26]. It consists of several successive and interrelated phases: coagulation (hemostasis), inflammation, fibroblast proliferation, and tissue remodeling [23,[27][28][29][30] (Figure 1). The initial stage is aimed at preventing excessive blood loss, for which it triggers the hemostatic mechanisms in response to bleeding [19,21,24].…”

“…Furthermore, the inflammatory phase is accompanied by activation of fibronectin synthesis induced by growth factors, as well as by migration of fibroblasts-pluripotent stromal cells that dominate cell populations on the first day and play a significant role in healing-towards the wound [11,30,33]. During this period, a large number of mediators are released into the wound, thus, providing the process of granulation formation, including proangiogenic growth factors that initiate the proliferation and organization of vascular endothelial cells [27,29,34,35].…”

“…The dynamic pathogenetic process of the healing of acute wounds depends on the balance of such factors as oxygenation, temperature, and pH [ 12 , 24 , 25 , 26 ]. It consists of several successive and interrelated phases: coagulation (hemostasis), inflammation, fibroblast proliferation, and tissue remodeling [ 23 , 27 , 28 , 29 , 30 ] ( Figure 1 ).…”

“…During this phase, the synthesis and lysis of collagen comes to equilibrium, excessive macromolecules degrade, and the cellular phenotypes and the integrity of the skin restore [ 11 , 31 , 38 , 39 , 40 ]. The criterion for successful wound treatment is the epithelialization of the wound surface, which depends on angiogenesis occurring through migration, proliferation, and organization of vascular endothelial cells, as well as the functional and anatomical restoration of the skin with no visible scar mark [ 30 , 41 , 42 , 43 ].…”