Studies on Trypanosoma vivax: Transmission of mouse infective T. vivax by tsetse flies

Gee, A.L.W. de; Ige, K.; Leeflang, P.

doi:10.1016/0020-7519(76)90028-x

Cited by 24 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two replicates with groups of 10 mice were performed, nevertheless, no parasite transmission was observed. This result was in accordance with the reduced/absent cyclical transmission of T. vivax in mice reported in the literature (De Gee et al, 1976 ; Leeflang et al, 1976 ; Moloo, 1981 ).…”

Section: Resultssupporting

confidence: 91%

The Cyclical Development of Trypanosoma vivax in the Tsetse Fly Involves an Asymmetric Division

Ooi

Schuster

Travaillé

et al. 2016

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Trypanosoma vivax is the most prevalent trypanosome species in African cattle. It is thought to be transmitted by tsetse flies after cyclical development restricted to the vector mouthparts. Here, we investigated the kinetics of T. vivax development in Glossina morsitans morsitans by serial dissections over 1 week to reveal differentiation and proliferation stages. After 3 days, stable numbers of attached epimastigotes were seen proliferating by symmetric division in the cibarium and proboscis, consistent with colonization and maintenance of a parasite population for the remaining lifespan of the tsetse fly. Strikingly, some asymmetrically dividing cells were also observed in proportions compatible with a continuous production of pre- metacyclic trypomastigotes. The involvement of this asymmetric division in T. vivax metacyclogenesis is discussed and compared to other trypanosomatids.

show abstract

Section: Resultssupporting

confidence: 91%

The Cyclical Development of Trypanosoma vivax in the Tsetse Fly Involves an Asymmetric Division

Ooi

Schuster

Travaillé

et al. 2016

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The IL 1392 West African stock of T. vivax is derived from the Nigerian isolate Zaria Y486 [23] which is infective for rodents and can be cyclically and/or mechanically transmitted [36], [37]. Rodent-infective derived clones of Y486 T. vivax , notably the IL 1392, have already been shown to express VSG ILDat 1.2 (ILRAD Duttonella antigen type 1.2) [19], [28], [38], [39] in a relatively stable fashion.…”

Section: Resultsmentioning

confidence: 99%

“…This parasite not only differs from other trypanosomes belonging to the Trypanozoon subgenus (i.e. T. brucei and T. equiperdum, but not T. evansi ) with regard to its transmission and tissue distribution in the host, but also is generally recognized as possessing diverse isolates which may or not express the ability to infect laboratory rodents [10], [23], [36],[65]. For instance, East African isolates are known to induce mild infections and hemorhagic syndromes in cattle and only some stocks are adapted to rodents.…”

Section: Discussionmentioning

confidence: 99%

Trypanosoma vivax Infections: Pushing Ahead with Mouse Models for the Study of Nagana. I. Parasitological, Hematological and Pathological Parameters

et al. 2010

View full text Add to dashboard Cite

African trypanosomiasis is a severe parasitic disease that affects both humans and livestock. Several different species may cause animal trypanosomosis and although Trypanosoma vivax (sub-genus Duttonella) is currently responsible for the vast majority of debilitating cases causing great economic hardship in West Africa and South America, little is known about its biology and interaction with its hosts. Relatively speaking, T. vivax has been more than neglected despite an urgent need to develop efficient control strategies. Some pioneering rodent models were developed to circumvent the difficulties of working with livestock, but disappointedly were for the most part discontinued decades ago. To gain more insight into the biology of T. vivax, its interactions with the host and consequently its pathogenesis, we have developed a number of reproducible murine models using a parasite isolate that is infectious for rodents. Firstly, we analyzed the parasitical characteristics of the infection using inbred and outbred mouse strains to compare the impact of host genetic background on the infection and on survival rates. Hematological studies showed that the infection gave rise to severe anemia, and histopathological investigations in various organs showed multifocal inflammatory infiltrates associated with extramedullary hematopoiesis in the liver, and cerebral edema. The models developed are consistent with field observations and pave the way for subsequent in-depth studies into the pathogenesis of T. vivax - trypanosomosis.

show abstract

“…The Zaria T. vivax strains are infective to calves, sheep and goats, as well as mice, rats and rabbits, and are readily transmissible by a wide range of tsetse species ( G. m. centralis, G. m. morsitans, G. pallidipes, G. austeni, G. brevipalpis, G. tachinoides, G. palpalis palpalis, G. p. gambiensis, G. fuscipes fuscipes ) [37,39-42]. Infection in these flies was typically found in the labrum and hypopharynx and sometimes also in the cibarium [41,42].…”

Section: Reviewmentioning

confidence: 99%

The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000

Gibson

2012

Parasites Vectors

View full text Add to dashboard Cite

The genomes of several tsetse-transmitted African trypanosomes (Trypanosoma brucei brucei, T. b. gambiense, T. vivax, T. congolense) have been sequenced and are available to search online. The trypanosome strains chosen for the genome sequencing projects were selected because they had been well characterised in the laboratory, but all were isolated several decades ago. The purpose of this short review is to provide some background information on the origins and biological characterisation of these strains as a source of reference for future users of the genome data. With high throughput sequencing of many more trypanosome genomes in prospect, it is important to understand the phylogenetic relationships of the genome strains.

show abstract

Studies on Trypanosoma vivax: Transmission of mouse infective T. vivax by tsetse flies

Cited by 24 publications

References 3 publications

The Cyclical Development of Trypanosoma vivax in the Tsetse Fly Involves an Asymmetric Division

The Cyclical Development of Trypanosoma vivax in the Tsetse Fly Involves an Asymmetric Division

Trypanosoma vivax Infections: Pushing Ahead with Mouse Models for the Study of Nagana. I. Parasitological, Hematological and Pathological Parameters

The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000

Contact Info

Product

Resources

About