Studies on transmural potentials in vitro in relation to intestinal absorption

Lyon, I.

doi:10.1016/0005-2736(67)90039-9

Cited by 22 publications

(7 citation statements)

References 53 publications

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“…concentration of Na, at which level the hexose transfer is considerably reduced. The maintenance of hexose-dependent potential at lowered Na concentration is in agreement with the results of Lyon & Crane (1966) who found that the hexose-dependent potential was maintained down to a Na concentration of 24 m-equiv/l. In the case of Li and K a maximum effect on transfer is produced at 80 m-equiv/l.…”

Section: Electrical Potential and Intestinal Transfer 655supporting

confidence: 91%

Relation between sodium concentration, electrical potential and transfer capacity of rat small intestine

Barry¹,

Eggenton²,

Smyth³

et al. 1967

The Journal of Physiology

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SUMMARY1. A study has been made of the effect of Na replacement in the incubation media on the hexose-dependent potential and the capacity of sacs of rat intestine to transfer fluid and galactose.2. Replacement of NaCl with mannitol or Tris Cl had little effect on the hexose-dependent potential, while replacement with LiCl and KCI had an inhibitory effect on the potential.3. Replacement with KCI, LiCl, mannitol and Tris Cl all reduced the capacity to transfer fluid and galactose, but the effects of Li and K replacement were greater than mannitol or Tris replacement.4. There is not a fixed relation between the magnitude of the potential and the amount of galactose transferred.

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Section: Electrical Potential and Intestinal Transfer 655supporting

confidence: 91%

Relation between sodium concentration, electrical potential and transfer capacity of rat small intestine

Barry¹,

Eggenton²,

Smyth³

et al. 1967

The Journal of Physiology

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“…Electrical events associated with active sugar transport in the small intestine can be regarded as phenomena related to cotransport of sugars and Na+ (Lyon and Crane 1966;Schultz et al 1967;Hoshi and Komatsu 1970). There is good evidence for that the coupled transport of sugars and Na+ takes place at the brush border membrane (Goldner et al 1969;Hoshi and Komatsu 1970;Maruyama and Hoshi 1972).…”

Section: Discussionmentioning

confidence: 99%

Interrelationship between Sugar-Evoked Increases in Transmural Potential Difference and Sugar Influxes across the Mucosal Border in the Small Intestine

Hoshi

Suzuki

Kusachi

et al. 1976

Tohoku J. Exp. Med.

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“…However, one study using everted sacs of small intestine (18) has suggested that mucosal uptake of short-chain fatty acids is not wholly explainable by passive diffusion. Another in vitro study (19) has suggested that a Na'-dependent, energy-independent system is involved in the uptake of oleic acid, a long-chain fatty acid, and of nonoolein. Hogben (20) has calculated that diffusion is sufficient to account for the rate of intestinal fatty acid absorption in vivo under normal conditions of gastric emptying.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of steady-state intestinal absorption of long-chain triglyceride by medium-chain triglyceride in the unanesthetized rat

Clark¹,

Holt²

1969

J. Clin. Invest.

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A B s T R A C T Maximal steady-state intestinal absorption rates in unanesthetized rats for triolein, a long-chain triglyceride, and for trioctanoin, a medium-chain triglyceride, are known to differ. Both these lipids are hydrolyzed in the intestinal lumen but the products of hydrolysis are metabolized differently by the mucosal cell. Intraduodenal infusion of trioctanoin was found to reduce steady-state triolein absorption. Luminal lipolysis was shown not to be rate-controlling. High rates of trioctanoin infusion significantly lowered the pH of the luminal aqueous phase and altered the partition of oleic acid between aqueous and oil phases. Two possible mechanisms for the inhibition of triolein uptake are considered. In the intestinal lumen medium chain lipids might have lowered the activity of oleic acid monomers in the aqueous phase and reduced passive diffusion into mucosal cells. Alternatively, competition between long and medium chain fatty acids for some common receptor during transport into the intestinal mucosal cell may have occurred.Despite significant inhibition of triolein absorption by high levels of trioctanoin, the maximum number of calories absorbed from mixtures of triglycerides exceeded the maxima from either glyceride alone. The optimum proportion of triolein to trioctanoin in lipid infusion mixtures was about 3: 4 by weight and the optimum dosages about half maximal for each triglyceride, which represented a caloric intake of 4 kcal/rat per 2 hr. The absorption coefficient for this lipid mixture was about 90%. It is suggested that in patients who have a limited intestinal absorptive capacity dietary fat intake might be doubled with a caloric supplement of mediumchain triglycerides without increase in steatorrhea of long-chain fat.This work was published in part as an abstract (1).

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Studies on transmural potentials in vitro in relation to intestinal absorption

Cited by 22 publications

References 53 publications

Relation between sodium concentration, electrical potential and transfer capacity of rat small intestine

Relation between sodium concentration, electrical potential and transfer capacity of rat small intestine

Interrelationship between Sugar-Evoked Increases in Transmural Potential Difference and Sugar Influxes across the Mucosal Border in the Small Intestine

Inhibition of steady-state intestinal absorption of long-chain triglyceride by medium-chain triglyceride in the unanesthetized rat

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