Studies on the use of Yucca schidigera to control giardiosis

McAllister, Tim A.; Annett, C. B.; Cockwill, C. L.; Olson, Merle E.; Wang, Y; Cheeke, P. R.

doi:10.1016/s0304-4017(01)00394-6

Cited by 44 publications

(27 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The anthelmintic effect of C. molle against nematode may be attributed to its saponin (Mc Allister et al, 2001). Monodesmoside saponins destabilize membranes and increase cell permeability by combining with membrane-associated sterols (Price et al, 1987 andGee andJohnson, 1988).…”

Section: Discussionmentioning

confidence: 99%

In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae

Ademola¹,

Eloff²

2010

Veterinary Parasitology

View full text Add to dashboard Cite

Parasitic nematodes, especially Haemonchus contortus (Rudolphi), are among the most common and economically important causes of disease in sheep and goats owned by pastoralists and small holder farmers in Africa. The control of these infections relies mainly on the use of anthelmintic drugs. However, herbal preparations are widely used by pastoralists and small holder farmers for the treatment of their livestock against helminth parasites. The anthelmintic effect of acetone leaf extract and fractions of Combretum molle was investigated to determine the relative efficacy of the components against gastrointestinal sheep nematodes. The fractions were obtained by solvent:solvent extraction from the acetone extract. These were evaluated for nematocidal activity by means of an egg hatch (EHA) and larval a development and viability assay (LDVA) in vitro. The effect of the test extracts on the hatchability of eggs and development of first to third stage larvae and the survival rate of the third stage larvae. H. contortus, were used to determine the relative bioactivities. Best-fit LC 50 values were computed using global model of nonlinear regression curve-fitting. The extracts inhibited egg hatching and development of the larvae of H. contortus in a concentration-dependent manner. Best-fit LC 50 values for the egg hatch test were 0.866, 0.333, 0.833, 0.747, and 0.065 mg/mL for acetone extract, n-butanol, hexane, chloroform, and 35% water in methanol fractions, respectively. The best-fit LC 50 values for the LDVA were 0.604, 0.362, 1.077, 0.131 and 0.318 mg/mL for the acetone extract, butanol, hexane, chloroform, and 35% water in methanol fractions, respectively. In the EHA the 35% water in methanol fraction was significantly more active than all the other fractions (p < 0.05); however the activity was not significantly different with the LDVA. C. molle leaf could find application in anthelmintic therapy in veterinary practice.

show abstract

Section: Discussionmentioning

confidence: 99%

In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae

Ademola¹,

Eloff²

2010

Veterinary Parasitology

View full text Add to dashboard Cite

show abstract

“…Further purification may exert more significant anti-giardial effects. 21 The gastrointestinal tract responded to the anti-protozoal activity of saponins. The saponins of Y. schidigera proved as effective as the drug metronidazole in killing tropozoites of Giardia lamblia in the intestine.…”

Section: Antimicrobialmentioning

confidence: 99%

Yucca: A medicinally significant genus with manifold therapeutic attributes

Patel

2012

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Abstract:The genus Yucca comprising of several species is dominant across the chaparrals, canyons and deserts of American South West and Mexico. This genus has long been a source of sustenance and drugs for the Native Americans. In the wake of revived interest in drug discovery from plant sources, this genus has been investigated and startling nutritive and therapeutic capacities have come forth. Apart from the functional food potential, antioxidant, antiinflammation, antiarthritic, anticancer, antidiabetic, antimicrobial, and hypocholesterolaemic properties have also been revealed. Steroidal saponins, resveratrol and yuccaols have been identified to be the active principles with myriad biological actions. To stimulate further research on this genus of multiple food and pharmaceutical uses, this updated review has been prepared with references extracted from MEDLINE database.

show abstract

“…Les saponosides auraient un effet anthelmintique par déstabilisation des membranes et augmentation de la perméabilité des cellules, ce qui va entrainer la turgescence des cellules et leur éclatement (McAllister et al, 2001 ;Aharoni et al, 2005 ;Ademola et al, 2009 L'étude des effets du macéré aqueux des feuilles de Salvadora persica, L. sur l'activité contractile de l'intestin isolé de lapin a montré qu'il a effet antispasmodique significatif à partir de la dose 1000 µg/ml, il devient plus prononcé pour les doses 3000 et 10000 µg/ml.…”

Section: Resultats Etude Toxicologiqueunclassified

Etude des effets vermicide et anti-diarrhéique du macéré aqueux des feuilles de <i>Salvadora persica</i>, L. (Salvadoraceae)

Garba¹,

Arya²,

Traore³

et al. 2017

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

Study of the vermicidal and antidiarrheal effects of the aqueous maceration of leaves of Salvadora persica, L. (Salvadoraceae) ABSTRACTThe present study was carried out to evaluate in vitro the vermicidal and antidiarrheal effects of the aqueous maceration of leaves of Salvadora persica L. (Salvadoraceae), a plant used in traditional medicine in Niger for the treatment of gastrointestinal parasitoses. In vitro, the aqueous maceration of leaves of Salvadora persica, L. has a significant vermicidal effect on adult worms Ascaridia galli, with 100% inhibition of their motility after 48 hours contact for the concentration range of 1 to 10 mg/ml. Its effect is effective but slower than levamisole 0.01% which gives 100% inhibition of motility, after only 2 hours. The normal contractile activity of the isolated rabbit intestine, as well as its contracture induced by 0.35 μM acetylcholine, were inhibited by the aqueous maceration of Salvadora persica, L. leaves at 10 mg / ml thus showing its A. B.H. GARBA et al. / Int. J. Biol. Chem. Sci. 11(1): 54-66, 2017 55 antispasmodic and anticholinergic effects. The aqueous maceration of leaves of Salvadora persica, L. would have vermicidal, anti-diarrheic and anticholinergic properties and Salvadora persica, L. would be a good candidate for the research and development of a phytomedicine for diarrhea.

show abstract

Studies on the use of Yucca schidigera to control giardiosis

Cited by 44 publications

References 32 publications

In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae

In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae

Yucca: A medicinally significant genus with manifold therapeutic attributes

Etude des effets vermicide et anti-diarrhéique du macéré aqueux des feuilles de <i>Salvadora persica</i>, L. (Salvadoraceae)

Contact Info

Product

Resources

About