Studies on the synthetic and structural aspects of benzosuberones bearing 2, 4-thiazolidenone moiety as potential anti-cancer agents

A Facile and Efficient Synthesis of Quinoxalines from Phenacyl Bromides and Ortho Phenylenediamine Promoted by Zirconium Tungstate

“…In continuation of our studies [25][26][27][28][29][30] towards the synthesis of To the best of our knowledge, in the literature there appear no reports for the synthesis and screening of quinoxalines derivatives using ZrO 2 / WO 3 . This fact has prompted us to investigate in depth the utility of 5% WO 3 /ZrO 2 for the synthesis of quinoxalines.…”

Design, Synthesis, and in vitro antitubercular activity of 1,2,3‐triazolyl‐dihydroquinoline derivatives

“…Quinolinebased compounds [10][11][12][13] are known to show antitubercular activity such as fluoroquinolones [14,15] and the quinoline alkaloids isolated from the leaves of Lunasia amara Blanco (family Rutaceae) [16] as shown in Figure 1 (I, II, III). [26,27] As a part of our ongoing studies devoted towards the development of a practical synthesis of biologically interesting heterocyclic molecules [28][29][30][31][32][33][34] , we report herein the synthesis of triazole-linked dihydroquinoline hybrids in good to excellent yields as depicted in Figure 2. [17] The 1,2,3-triazole core is considered as a privileged structure in medicinal chemistry and is widely used as "parental" compounds to synthesize molecules with medical benefits, especially with infection-related activities.…”

Synthesis and Biological Evaluation of Triazole linked Thiazolidenone Glycosides

“…3aR,5S,6S,6aR)-6-((1-(4-Chlorophenyl)-1H-1,2,3-triazol-4-yl) , 3226, 2982, 2971, 2830, 1710, 1608, 1546, 1512, 1414, 1374, 1216, 865 4, 143.2, 134.8, 131.2, 128.6, 124.6, 122.4, 119.8, 111.8, 104.9, 81.5, 78.2, 74.8, 66.9, 52.4, 34.6, 26.8 ,4.21;N,12.20. Found: C,52.26;H,4.19;N,12.11. 6, 144.6, 138.7, 134.8, 134.3, 130.6, 129.4, 128.6, 125.8, 122.6, 119.8, 111.6, 104.8, 81.7, 78.6, 74.7, 66.5, 52.4, 26.6, 16.5 ClN 4 O 5 S: C,57.51;H,5.51;N,10.32.…”

“…Thiazolidenone and its derivatives are known to possess significant pharmacological 6 and biological activities, 7 like sedative, 8 anti inflammatory, 9 anti tubercular, 10 anticancer, 11 antitumor, 12 anti-HIV, 13 antibacterial, 14 antifungal, 15 analgesic, hypothermic, 16 anesthetic, 17 nematicidal 18 and CNS stimulant. 19 Furthermore, thiazolidenones have been used for the treatment of cardiac diseases, 20 diabetic complications, like cataract nephropathy, neuropathy, 21 and as selective anti platelet activating factor.…”