Studies on the Role of Antibodies in the Failure of Homografts

The Role of Humoral Antibodies in Rejection of Skin Homografts in Rabbits

“…(a) Evidence against Participation of Humoral Antibodies.--Many authors have reported failure to transfer transplantation immunity by means of serum (42)(43)(44)(45)(46). In addition, the studies of Algire et al (47,48) and others (49)(50)(51) showed prolonged survival of homografts in diffusion chambers, which are impervious to cells but presumably not to humoral factors.…”

Passive Transfer of Transplantation Immunity

“…There have been numerous reports from different groups of investigators attempting to demonstrate that serum antibodies, cell bound antibodies, or both, were responsible agents in homograft rejection (6). In several species solid skin grafts have been destroyed by serum from immunized hosts, injected either locally or at a distance (2)(3)(4)(5). Others have repeatedly shown that serum from tissue-sensitized animals contained cytotoxic and hemagglutinating antibodies when tested against cell suspensions of normal or neoplastic tissues (6).…”

La réaction cutanée de type homogreffe chez l’homme

“…Signalé par Voisin et Maurer, 1957 [59], chez le lapin, décrit chez l'homme par Rapaport et Converse, 1957 [48], le phénomène du «recall flare» consiste en une réaction in flammatoire fugace au niveau du prem ier greffon, lors de l'appli cation d'un 2'' greffon (second set). Cette réaction fugace dure tant que le sujet est hvpersensible pour disparaître ensuite.…”