Studies on the Relationship of the Hepatitis Virus to Persistent Symptoms, Disability, and Hepatic Disturbance (“Chronic Hepatitis Syndrome”) Following Acute Infectious Hepatitis 1

Serum Jaundice

“…Transmission experiments in volunteers have failed to reveal any evidence that the patient recovered from infective hepatitis, or the one who develops chronic hepatitis, continues to carry the virus in the blood or excrete it in the faeces." 12 Similarly, Oliphant and others, MacCallum and Bauer, and Havens'3 have all failed to find any evidence of an icterogenic agent in the serum of cases of serum jaundice two months or more after their attack. In a follow-up of donors in Lehane's investigations only one could be traced who had had jaundice, and his illness occurred three months after he had been bled.…”

The hepatitis A virus infection

“…Attempts in volunteers to transmit the infection using stool and serum collected 3-12 months after the acute illness have been inconclusive (169).…”

The Biliary Excretion of Bromsulfalein as a Test of Liver Function in a Group of Patients Following Hepatitis or Serum Jaundice

“…However, the incidence of this chronic hepatic disease is not well established because of the difficulty in correlating symptomatology with the available liver function tests or with liver biopsy (12)(13)(14)(15).…”