Studies on the Pathogenesis and Morphogenesis of Glomerulonephrosis

Torhorst, J.

doi:10.1007/978-3-642-65857-0_1

Cited by 9 publications

(3 citation statements)

References 78 publications

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“…The calculation of the minimum number For reliable evaluation of the area density of the interof glomeruli presented in tables 11 and III takes individual stitium a biopsy should measure at least 3 mm2 (table II), and age-dependent variations into consideration (table IV) Group 1 = Kidneys with large glomeruli (20-75 years); glomerular diameter 241 ± 6 p.m (mean ±SE ); group 2 = kidneys with small glomeruli (20-75 years); glomerular diameter 195±11 |xm (mean ±SE ); group 3 = kidneys of young adults (20-30 years); group 4 = kidneys of old adults (65-75 years); group 5 = children (3-12 years). 1 Calculated on the basis of data published by Torhorst [2].…”

Section: Resultsmentioning

confidence: 99%

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Minimum Sample Size of Kidney Biopsies for Semiquantitative and Quantitative Evaluation

Oberholzer

Torhorst

Perret

et al. 1983

Nephron

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The minimum sample size for semiquantitative and quantitative evaluation of interstitial tubular and glomerular parameters is calculated. For the majority of parameters a renal cortex area of 2 mm² or 7 glomeruli (adults) or 13 glomeruli (children) is sufficient. Larger biopsies or more glomeruli are necessary for the evaluation of the area density of interstitium patent and obsolescent glomeruli as well as the numerical density of obsolescent glomeruli. The most sensitive parameters are those concerning crescents which require biopsies of 11–19 glomeruli in adults and 40 glomeruli in children. In summary, biopsies of usual size (10 mm²) containing about 20 glomeruli are sufficient for qualitative and quantitative evaluation.

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Section: Resultsmentioning

confidence: 99%

“…The morphometric technique is described elsewhere in detail [2]. PASstained, 3 ¡xm thick sections were used [for methodical details of light microscopic preparations see ref.…”

Section: Methodsmentioning

confidence: 99%

Minimum Sample Size of Kidney Biopsies for Semiquantitative and Quantitative Evaluation

Oberholzer

Torhorst

Perret

et al. 1983

Nephron

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“…Correlation between kidney weight and body weight The second parameter for assessing nephron size was the tubular mass: the tubules and the interstitium constitute 95% of the cortical mass [2] and if the volume composed by the tubules increases, the relative number of glomeruli per unit surface will decrease and vice versa.…”

Section: Methodsmentioning

confidence: 99%

Quantitative Relationships between Body Weight, Kidney Weight and Nephron Size in Mongrel Dogs

Zhu

Vaneerdeweg

Buyssens

et al. 1992

Nephron

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Mammalian species of large stature have larger kidneys with larger nephrons than smaller animals, although this relationship is not linear. In order to investigate whether in animals of different sizes within the same species similar differences exist, a study in mongrel dogs was undertaken. In animals weighing between 9 and 42 kg with kidney weights from 25 to 79 g the area and perimeter of the glomeruli and the cortical width were measured. The number of glomeruli per unit area was counted and corrected for the size of the glomeruli. The results show that larger dogs have larger kidneys and that this enlargement is due to the increase in size of the nephrons and not in their number.

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Zur Morphologie und Pathogenese der diabetischen Glomerulosklerose

Romen

1980

Klin Wochenschr

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The diabetic glomerulosclerosis as a consequence of the abnormal metabolic state is characterized by an uniform thickening of the glomerular basement membrane (GBM) and an augmentation of the mesangial matrix. Both alterations begin already few years after the onset of the diabetes and are observed in all glomeruli to the same extent (=diffuse type). Later on, nodular deposits of glycoproteins are additionally found in the mesangium (=nodular type). Only these nodules are morphologically specific for the diabetic disorder. In association with both the diffuse and the nodular glomerulosclerosis, insudation of plasma can be seen in the afferent and efferent vessels and the glomerular capillary loops. The mechanism of the increase in the amount of GBM-material is not known, since contradictory data have been reported with regards to both the chemical composition and metabolism of the GBM in human and experimental diabetes. Some postulate that the abnormal deposition of GBM-mateiral is due to an excessive synthesis (anabolic disorder), others argue that a further decrease in the normally slow breakdown and disposal (catabolic disorder) might be responsible. This review presents the different pathogenetic concepts of the glomerulosclerosis and attemps to explain the possible causes for the current discrepancies.

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Studies on the Pathogenesis and Morphogenesis of Glomerulonephrosis

Cited by 9 publications

References 78 publications

Minimum Sample Size of Kidney Biopsies for Semiquantitative and Quantitative Evaluation

Minimum Sample Size of Kidney Biopsies for Semiquantitative and Quantitative Evaluation

Quantitative Relationships between Body Weight, Kidney Weight and Nephron Size in Mongrel Dogs

Zur Morphologie und Pathogenese der diabetischen Glomerulosklerose

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