Minimum Sample Size of Kidney Biopsies for Semiquantitative and Quantitative Evaluation

Oberholzer, M.; Torhorst, J.; Perret, E.; Mihatsch, Michael J.

doi:10.1159/000183008

Cited by 32 publications

(18 citation statements)

References 3 publications

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“…However, the results of the 87 real-time ultrasound-guided RBs with a biopsy gun performed in this study can be compared with most reports by other authors in which the number of RBs ranges from 50 to 177 (2,3,5,7,8,14,15). Similarly to these reports, no serious adverse events were observed in this study.…”

Section: Discussionsupporting

confidence: 72%

“…Similarly to these reports, no serious adverse events were observed in this study. Serious complications such as severe bleeding, which requires either blood transfusion or surgical intervention, and even death are reported in some studies with a much higher number of RBs, most of which either were performed over several decades or were from several centres (4,5,13,19 (2,(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…at least 5 glomeruli for light-microscopic evaluation (14), . at least 13 glomeruli per biopsy specimen in children under 12 y or 7 glomeruli per biopsy specimen in adolescents over 12 y (15).…”

Section: Renal Biopsymentioning

confidence: 99%

“…In general, 5-20 glomeruli are considered an adequate renal tissue sample for pathohistological tests, and 79-99% of RBs fall within this range (2,11,(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Real-time ultrasound-guided renal biopsy with a biopsy gun in children: safety and efficacy

Levart¹

2001

Acta Paediatrica

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Renal Biopsymentioning

confidence: 99%

“…In general, 5-20 glomeruli are considered an adequate renal tissue sample for pathohistological tests, and 79-99% of RBs fall within this range (2,11,(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Real-time ultrasound-guided renal biopsy with a biopsy gun in children: safety and efficacy

Levart¹

2001

Acta Paediatrica

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“…All patients fulfilled the International Study of Kidney Disease in Children (ISKDC) criteria, for the diagnosis of nephrotic syndrome: nephrotic-range proteinuria (urinary spot protein/creatinine >2.0), hypoalbuminemia (serum albumin <2.5 g/dl), hyperlipidemia (serum cholesterol >200 mg/dl), and/or edema [6]. An adequate biopsy was defined as the presence of at least 5 glomeruli in the specimen on light microscopy [9]. The biopsy specimens were evaluated histopathologically by light and immunofluorescence microscopy.…”

Section: Methodsmentioning

confidence: 99%

Histopathological spectrum of childhood nephrotic syndrome in Indian children

et al. 2003

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Nephrotic syndrome in children is a clinical manifestation of different histopathological subtypes. There is a paucity of recent large studies dealing with the histopathological spectrum from developing countries. A prospective study was performed from January 1990 to December 2000 at our center, involving 600 children (with age of onset up to 16 years) with idiopathic nephrotic syndrome (INS). The objectives were: (1) to study the histopathological distribution of different subtypes of INS and (2) to compare the clinical and biochemical parameters at the time of diagnosis of minimal change disease (MCD) with non-MCD subtypes. For the purpose of this study we analyzed only those children with INS who underwent biopsies. The study group included 290 children in which adequate biopsy reports were available. There were 213 males and 77 females. Mean age at onset of INS was 7.9+5.1 years. Facial edema was found in 286 (98.6%), microhematuria in 120 (41.3%), gross hematuria in 7 (2.5%), and hypertension in 77(26.8%) patients. All patients of the study group were seronegative for HBsAg and HIV. Focal and segmental glomerulosclerosis (FSGS) was the most common histopathological subtype, occurring in 110 of 290 children (38%). Other subtypes included MCD in 95 children (32%), membranoproliferative glomerulonephritis (MPGN) in 44 children (15%), mesangioproliferative glomerulonephritis in 33 children (11%), membranous glomerulonephritis in 5 children (2%), and diffuse mesangial sclerosis in 3 children (1%). In children under 8 years of age, MCD was the most common entity, whereas FSGS predominated in children with age at onset greater than 8 years. The age at onset of nephrotic syndrome was significantly higher in the non-MCD group than the MCD group. The incidence of hypertension, microhematuria, and gross hematuria was significantly lower in the MCD group. MCD remains the most common histopathological subtype in Indian children with INS and onset under 8 years of age. The incidence of MPGN continues to be high. MCD can be differentiated from non-MCD subtype by younger age at onset, absence of hypertension, and absence of microscopic hematuria.

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