Extracts from the corpus cardiacum-corpus allatum-aorta (CC-CA-A) complex of Glossina morsitans morsitans Westwood contain a hypertrehalosaemic factor when assayed in Periplaneta americana L. and in G.morsitans. A slight though significant decrease, followed by an increase, in haemolymph total carbohydrate occurs when tsetse are flown for 1 h. When assayed in Locusta migratoria L., the extracts have no adipokinetic activity, but Lmigratoria corpus cardiacum extract produces an adipokinetic response in the female tsetse. It is suggested that the neurosecretions contained in the tsetse CC-CA-A complex contain a hypertrehalosaemic factor whose role is to mobilize glycogen.