Studies on the Mode of Action of Intra‐Amniotically and Extra‐Amniotically Injected Hypertonic Saline in Therapeutic Abortion

Foley catheter versus intra-vaginal misoprostol for induction of labor in post-term gestations

“…The high incidence associated with extra-amniotic saline infusion is because saline inWltrates the entire choriodecidual space [26], potentially inoculating the uterine cavity with vaginal Xora. Furthermore, inXammatory mediators are released through stimulation of the decidua by saline [27].…”

Reproductive Hormones during Termination of Early Pregnancy with Mifepristone

“…The release of phospholipase A2 from decidual-cell lysosomes has been suggested as a trigger mechanism for prostaglandin synthesis [14], Progesterone may stabilize the lysosomal membranes [15], and the antiprogestational effect of mifepristone would labilize these mem branes, leading to a release of phospholipase A2. Electron microscope studies have confirmed the lysis of decidual cells 24 h after mifepristone treatment [16], Arachidonic acid, released from the cellular membranes by phospho lipase A2, is then transformed to prostaglandins by cyclo oxygenase.…”

May spina bifida result from an X-linked defect in a selective abortion mechanism?

“…These hormones are effective in causing myometrial contraction and abortion at any time during gestation (Toppozada et al, 1972), while, conversely, their inhibition blocks myometrial activity (Vane and Williams, 1972). Prostaglandin synthesis may depend on lysosomes (Gustavii, 1973) and these are very plentiful in the decidua at the fetomaternal junction (Liggins and Grieves, 1971). Any trauma to these vesicles, particularly from hormonal imbalance, leads to prostaglandin release (Bitensky and Cohen, 1965).…”