Studies on the metabolic fate of [14C]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse

Koshakji, Richard P.; Harbison, Raymond D.; Bush, Milton T.

doi:10.1016/0041-008x(84)90054-1

Cited by 29 publications

(12 citation statements)

References 16 publications

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“…It has been reported that the half-life of TCDD is approximately 7 years in humans [17] and 20 days in mice [12], and the Seveso and Russian data have shown that an increased probability of female births is related to increasing TCDD concentrations in fathers rather than in the mothers [15,16,20]. Based on these reports, we followed a modified version of Faqi's regimen of repeated exposure with low doses [4] in order to maintain a body TCDD burden in male mice as close to that of the human situation.…”

Section: Discussionmentioning

confidence: 99%

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Dose Paternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) affect the Sex Ratio of Offspring?

Ishihara

Warita

Tanida

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. In 1976, men who were exposed to the highest concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after an explosion at a chemical plant near Seveso, Italy, produced more girls than boys. However, few studies have examined the possibility that the exposure of laboratory animals to TCDD, especially that of males, could lead to a lower male/female sex ratio. The aim of this study was to investigate whether direct paternal exposure to TCDD affects the sex ratio of offspring using a relatively large-scale experimental design. Male ICR mice (n=120) were randomly assigned to three, one of which served as a vehicle control, the other two were administered TCDD orally with an initial loading dose of 2 or 2,000 ng TCDD/kg, followed by a weekly maintenance dose of 0.4 (T2/0.4 group) or 400 (T2000/400 group) ng/kg prior to mating. The major organs of each mouse were weighed and histopathologically and immunohistologically investigated, and the sex ratio of offspring [males/(males + females) × 100] was calculated in each dam. There were no significant effects on organ weights, or on the structure of the testis and epididymis between the control and TCDD-exposed males, but TCDD administration produced a significantly lower proportion of male offspring from T2000/400-exposed sires despite no alteration in litter size (Control: 53.1 ± 1.7; T2/0.4: 48.8 ± 2.5; T2000/400: 46.2 ± 2.1). In addition, we further divided the T2000/400 group into 3 subgroups based on the proportion of CYP1A1-immunoreactive areas in the liver; there was a significant correlation between sex ratio and CYP1A1 immunoreactivity. Thus, the present study confirms that direct paternal exposure to TCDD might be associated with an alteration in the sex ratio of offspring. Possible mechanisms through which TCDD might decrease the fertility potential of Ybearing gametes before conception are discussed. KEY WORDS: CYP1A1, paternal exposure, Seveso data, sex ratio of offspring, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

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Section: Discussionmentioning

confidence: 99%

“…In ICR/Ha Swiss mice, the half-life for TCDD elimination, t 1/2 , is approximately 20 days [12]. To maintain the body TCDD burden as constant as possible in our study, we followed Faqi's regimen of administration, which consists of an initial loading dose followed by weekly maintenance doses [4].…”

mentioning

confidence: 99%

Dose Paternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) affect the Sex Ratio of Offspring?

Ishihara

Warita

Tanida

et al. 2007

The Journal of Veterinary Medical Science

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“…Octachlorodibenzo-p-dioxin (OCDD), 2,3,7,3,7, and 3,3′,4,4′-tetrachlorobiphenyl (3,3′,4,4′-TCB) were well absorbed from intestine and excreted at more than 100% of intake, mainly from the sebum. In contrast, 1,2,3,4,7,2,3,4,7,2,3,7,8,2,3,7,8, were excreted at relatively low levels from sebum, although well absorbed from the intestine, and the excretion ratios were lowest among the 20 congeners. It was suggested that 80.5-85.2% TEQ of each congener-group might be absorbed from the intestine, after taking bile excretion into consideration.…”

mentioning

confidence: 89%

“…The metabolism of these compounds has been well studied in experimental animals, [1][2][3] however, human data is limited. The half-life of 2,3,7,8-tetradibenzop-dioxin (2,3,7, has been estimated to be 8.7 years (8.0-9.5 years) in a study of 343 Vietnam War veterans, using blood samples from 1982-1992, 4) and other studies on Germans indicated 5.8 years 5) and 7.2 years.…”

Section: Introductionmentioning

confidence: 99%

“…8 ± 5.6 pg TEQ, respectively, indicating 22% the daily intake of dioxins from meals is excreted from feces and 29% from sebum. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin (1,2,3,7,2,3,4,7,3,4,7, and 3,3′,4,4′,5-pentachlorobiphenyl (3,3′, 4,4′,5-PeCB) were most abundant in TEQ, in meals, feces, sebum and blood. Co-PCBs were most efficiently excreted among three congener groups in TEQ, especially from sebum.…”

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confidence: 99%

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Balance of Intake and Excretion of 20 Congeners of Polychlorinated Dibenzo-p-dioxin, Polychlorinated Dibenzofuran and Coplanar Polychlorinated Biphenyl in Healthy Japanese Men.

Kitamura

Nagahashi

Sunaga

et al. 2001

JOURNAL OF HEALTH SCIENCE

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Daily intake from meals, and excretion from feces and sebum of 20 congeners of polychlorinated dibenzo-pdioxin (PCDD), polychlorinated dibenzofuran (PCDF) and coplanar polychlorinated biphenyl (Co-PCB) were analyzed in healthy Japanese men who are considered to be a standard for the Japanese. Daily intake of these congeners was 84.2 ± 12.5 pg toxic equivalent (TEQ) and daily excretion from feces and sebum were 18.3 ± 5.9 and 23. 8 ± 5.6 pg TEQ, respectively, indicating 22% the daily intake of dioxins from meals is excreted from feces and 29% from sebum. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin (1,2,3,7,2,3,4,7,3,4,7, and 3,3′,4,4′,5-pentachlorobiphenyl (3,3′, 4,4′,5-PeCB) were most abundant in TEQ, in meals, feces, sebum and blood. Co-PCBs were most efficiently excreted among three congener groups in TEQ, especially from sebum. Octachlorodibenzo-p-dioxin (OCDD), 2,3,7,3,7, and 3,3′,4,4′-tetrachlorobiphenyl (3,3′,4,4′-TCB) were well absorbed from intestine and excreted at more than 100% of intake, mainly from the sebum. In contrast, 1,2,3,4,7,2,3,4,7,2,3,7,8,2,3,7,8, were excreted at relatively low levels from sebum, although well absorbed from the intestine, and the excretion ratios were lowest among the 20 congeners. It was suggested that 80.5-85.2% TEQ of each congener-group might be absorbed from the intestine, after taking bile excretion into consideration.

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Dibenzo‐p‐Dioxins: 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin

Reid¹

2002

Encyclopedia of Agrochemicals

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Dibenzo‐ p ‐dioxins are a class of compounds of which there are 75 possible isomers as shown. A recent IARC Monograph summarizes much of the information on these compounds. By far, the majority of the information is for 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD), the most toxic of the isomers. Most of the material in this chapter relates to this compound.

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Studies on the metabolic fate of [14C]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse

Cited by 29 publications

References 16 publications

Dose Paternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) affect the Sex Ratio of Offspring?

Dose Paternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) affect the Sex Ratio of Offspring?

Balance of Intake and Excretion of 20 Congeners of Polychlorinated Dibenzo-p-dioxin, Polychlorinated Dibenzofuran and Coplanar Polychlorinated Biphenyl in Healthy Japanese Men.

Dibenzo‐p‐Dioxins: 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin

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