Studies on the mechanisms of invasion in cancer. I. Isolation and purification of a factor chemotactic for cancer cells

Yoshida, Keishiro; Ozaki, Teruhisa; Ushijima, Kenichiro; Hayashi, Hideo

doi:10.1002/ijc.2910060116

Cited by 42 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Others have reported on related properties of transformed cells and the effects oftheir products on motility in normal cells (23,24,36). At least two gene products of the transformed cell may be important: an autocrine motility factor and its receptor.…”

Section: Discussionmentioning

confidence: 99%

Tumor cell autocrine motility factor.

Liotta¹,

Mandler²,

Murano³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

480

272

View full text Add to dashboard Cite

A cell motility-stimulating factor has been isolated, purified, and partially characterized from the serumfree conditioned medium of human A2058 melanoma cells. We term this activity "autocrine motility factor" (AMF). AMF has the properties of a protein with an estimated size of 55 kDa. At concentrations of 10 nM or less, AMF stimulated the random or directed motility of the producer cells. However, AMF is not an attractant for neutrophils. Amino acid analysis of the purified AMF protein revealed a high content of serine, glycine, glutamic acid, and aspartic acid residues. The activity of AMF was not replaced or blocked by known growth factors such as epidermal growth factor or type p transforming growth factor.

show abstract

Section: Discussionmentioning

confidence: 99%

Tumor cell autocrine motility factor.

Liotta¹,

Mandler²,

Murano³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

480

272

View full text Add to dashboard Cite

show abstract

“…Subcutaneous transplantation of AH109A cells.-I 5 x 107 of AH109A cells were transplanted s.c. into the backs of normal Donryu rats Yoshida et al, 1970). Seven days later, growing tumours were removed for light and electron microscopic observation.…”

Section: Methodsmentioning

confidence: 99%

The induction of tumour cell adhesiveness and intercellular junctions by a glycoprotein of rat ascites hepatoma cell surface

Ishimaru¹,

Kudo²,

Ishihara³

et al. 1976

Br J Cancer

View full text Add to dashboard Cite

“…As described in previous papers Yoshida et al, 1970), a substance chemotactic for cancer cells has been isolated from some tumour tissues of animal and human origin. After injection, this substance locally induced an extravascular migration of circulating tumour cells and the formation of metastatic tumour (Ozaki et al, 1971).…”

Section: The Mechanisms Of Invasion In Cancermentioning

confidence: 99%