Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement

Varga, Lilian; Szilágyi, Katalin; Lőrincz, Zsolt; Berrens, L.; Thiel, Steffen; Závodszky, Péter; Daha, Mohamed R.; Thielens, Nicole M.; Arlaud, Gérard J.; Nagy, Kálmán; Späth, Peter; Füst, George

doi:10.1016/s0161-5890(03)00023-3

Cited by 14 publications

(13 citation statements)

References 30 publications

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“…It binds allergens/antigens, activates the lectin complement pathway and modulates the levels of proinflammatory cytokines [14][15][16][17]. Varied levels of MBL in the serum have been associated with protection and/or susceptibility to several infectious and non-infectious diseases [13].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Kaur

Gupta

Shah

et al. 2006

Clinical and Experimental Immunology

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SummaryMannan-binding lectin (MBL), an important component of innate immunity, binds to a range of foreign antigens and initiates the lectin complement pathway. Earlier studies have reported high plasma MBL levels in allergic patients in comparison to healthy controls. In view of varied plasma MBL levels being determined by genetic polymorphisms in its collagen region, we investigated the association of single nucleotide polymorphisms (SNPs) in the collagen region of human MBL with respiratory allergic diseases. The study groups comprised patients of bronchial asthma with allergic rhinitis ( n = = = = 49) and allergic bronchopulmonary aspergillosis (APBA) ( n = = = = 11) and unrelated agematched healthy controls of Indian origin ( n = = = = 84). A novel intronic SNP, G1011A of MBL , showed a significant association with both the patient groups in comparison to the controls ( P < < < < 0·01). Patients homozygous for the 1011A allele showed significantly higher plasma MBL levels and activity than those homozygous for the 1011G allele ( P < < < < 0·05). The 1011A allele also showed a significant correlation with high peripheral blood eosinophilia ( P < < < < 0·05) and low forced expiratory volume in 1 s (FEV 1 ) ( P < < < < 0·05) of the patients. We conclude that the 1011A allele of MBL may contribute to elevated plasma MBL levels and activity and to increased severity of the disease markers in patients of bronchial asthma with allergic rhinitis and ABPA.

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Section: Introductionmentioning

confidence: 99%

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Kaur

Gupta

Shah

et al. 2006

Clinical and Experimental Immunology

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“…However, through the production of proinflammatory cytokines and the activation of complement system, MBL has an impact on the generation and regulation of the inflammatory response [30]. In a study by Varga et al [31], involvement of the lectin pathway in allergen-induced activation of complement was demonstrated. The study indicated that allergen extracts can bind purified MBL and activate the lectin complement pathway, but they require IgG for efficient complement activation.…”

Section: Mbl Levels and Activity In Allergicmentioning

confidence: 99%

Mannan-Binding lectin in asthma and allergy

Kaur¹,

Thiel²,

Sarma³

et al. 2006

Curr Allergy Asthma Rep

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Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing to several infectious diseases. However, recent studies propose that MBL extends beyond its classic role as a first-line host-defense molecule to a modulator of inflammation. In this review, we summarize and explore this potential and a possible novel role of MBL in asthma and allergy.

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“…Recently, several studies have mentioned the important role of MBL on pathophysiological mechanisms of allergies [9][10][11]. Some researchers have defined that MBL concentration of serum was significantly different in allergic patients and healthy people [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

Cent Asian J Med Sci

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Objectives: Mannose-binding lectin (MBL) is a vital protein of an innate immune system synthesized by the liver. The serum level of MBL is associated with an increased susceptibility to infection with a high risk of allergic and autoimmune diseases. The aim of this study was to determine the profile of serum levels of MBL in atopic and healthy Mongolian subjects. Methods: Serum samples were collected from 219 healthy Mongolian adult blood donors and 216 atopic subjects. We analyzed the MBL level in each serum by using the double-antibody sandwich ELISA method. Results: The mean serum level of MBL was 3088.28 ± 669.8 ng/ ml in atopic subjects and 2165.07 ± 708.5 ng/ml in healthy groups. In males, the MBL mean serum level of atopic subjects was 3012.8 ± 783.16 ng/ml and 2073.33 ± 678.26 ng/ml in the healthy group of males. The MBL mean serum level of female atopic subjects was 3138.22 ± 580.6 ng/ml and 2263.61 ± 733.1 ng/ml in the healthy group of females. Low association and significant differences were observed between MBL levels of atopic and healthy subjects. Conclusion: The serum level of MBL in atopic subjects was comparatively higher than in subjects of the healthy group. Significant differences were observed between mean levels of MBL between the different age groups.

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Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement

Cited by 14 publications

References 30 publications

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Mannan-Binding lectin in asthma and allergy

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