Mannan-Binding lectin in asthma and allergy

Kaur, Savneet; Thiel, Steffen; Sarma, P. Usha; Madan, Taruna

doi:10.1007/s11882-996-0007-6

Cited by 13 publications

(5 citation statements)

References 49 publications

(51 reference statements)

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“…This observation is in concordance with studies reporting higher MBL levels in both children and adult patients with asthma and/or allergic rhinitis compared to healthy controls [28]–[31], The increased MBL levels and activity also correlated with peripheral blood eosinophilia in these patients [29], [30]. Interestingly, Staley et al found even a positive correlation between MBL levels and the severity of asthmatic symptoms in young children [32].…”

Section: Discussionsupporting

confidence: 88%

“…Interestingly, Staley et al found even a positive correlation between MBL levels and the severity of asthmatic symptoms in young children [32]. One can speculate that high MBL levels may contribute to increased complement activation via the lectin pathway, and the complement-activated products C3a and C5a may lead to inflammatory sequelae [31]. In addition, MBL deficiency is associated with an increased number of infections in childhood [9], [33]; which in turn might play a protective role against development of atopy/asthma in adulthood.…”

Section: Discussionmentioning

confidence: 99%

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Association between Low Levels of Mannan-Binding Lectin and Markers of Autoimmune Thyroid Disease in Pregnancy

et al. 2013

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Functional deficiency of mannan-binding lectin (MBL) has been associated with adverse pregnancy outcome. Adverse events during pregnancy have also been described in women with autoimmune thyroid diseases (AITD), and thyroid hormones have been shown to influence serum levels of MBL. Therefore, the aim of this study was to analyse the impact of MBL-deficiency on the outcome of pregnancy in relation to the presence of AITD. Almost one year after delivery, we assessed serum MBL levels and MBL2-genotypes in 212 women positively screened for AITD in pregnancy. In 103 of these women, we could also measure MBL levels in frozen serum samples from the 9-12th gestational week, obtaining 96 pairs of MBL values (pregnancy vs. follow-up). As controls, 80 sera of pregnant women screened negatively for AITD were used. MBL2-genotyping was performed using multiplex PCR. Women with thyroid dysfunction and/or thyroid peroxidase antibodies (TPOAb) had lower MBL levels during pregnancy than controls, (3275 vs. 5000 ng/ml, p<0.05). The lowest levels were found in women with elevated thyroid-stimulating hormone (TSH) levels in the absence of TPOAb (2207 ng/ml; p<0.01 as compared to controls). MBL2 genotype distribution did not differ between subgroups. At a median follow-up period of 17 months (range: 3–78 months) after delivery, median MBL level had decreased further to 1923 ng/ml (p<0.0001) without significant changes in TSH. In an explorative survey, functional MBL-deficiency was neither linked to a history of spontaneous abortion, nor other obstetric complications, severe infections throughout life/pregnancy or antibiotics use in pregnancy. In conclusion, hypothyroidism during pregnancy is associated with decreased MBL levels, and the levels decreased further after delivery.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Association between Low Levels of Mannan-Binding Lectin and Markers of Autoimmune Thyroid Disease in Pregnancy

et al. 2013

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“…Interestingly, serum MBL deficiency has been observed in 10-15% of Caucasians with significantly higher percentages reported in subjects of African or South American Indian descent (Bouwman et al, 2006). Such deficiencies and their variant alleles within the coding region of MBL have been associated with increased susceptibility to bacterial infections in neutropenic patients, poorer prognosis in cystic fibrosis patients, or more severe meningococcal disease (Eisen and Minchinton, 2003;Bouwman et al, 2006;Kaur et al, 2006b). There is very preliminary epidemiologic evidence to suggest MBL is important for clearance of several common viruses (hepatitis B, HIV, and influenza A) but virtually nothing is known about how MBL levels might affect the immune response to HSV infection (Bouwman et al, 2006).…”

Section: Pattern Recognition Receptorsmentioning

confidence: 99%

Atopic Dermatitis: A Disease Caused by Innate Immune Defects?

Benedetto

Agnihothri

McGirt

et al. 2009

Journal of Investigative Dermatology

280

213

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Atopic dermatitis (AD) is a common chronic inflammatory skin disease that has increased in prevalence over the last half century. A growing body of evidence suggests that there are a variety of defects in the innate immune system that collectively affect the development and severity of AD. The reduction in antimicrobial peptides, diminished recruitment of innate immune cells (PMNs, pDC, and NK cells) to the skin, epithelial barrier disruption, and TLR2 defects are just some of the credible explanations for AD patients' susceptibility to pathogens such as Staphylococcus aureus, herpes simplex virus, and vaccinia virus. Although the focus for several years has been to identify defects in the innate immune system that might explain AD patients' susceptibility to cutaneous pathogens, it has become clear that some innate immune defects might promote inflammation and thereby aggravate or even induce the development of AD. Here we review the innate immune system, and highlight many of the potential innate networks that may be important in AD patients susceptible to cutaneous pathogens.

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“…Other studies investigate only some of the possible haplotypes. Further analysis of results may also be required in the light of the recently discovered intronic SNP G1011A in an Indian population [92]. Homozygotes for G at 1011 had approximately twice the serum concentration of MBL as those homozygotic for A.…”

Section: Perspectivesmentioning

confidence: 99%