Studies on the Mechanism of Action of Methotrexate and Cyclophosphamide on Contact Sensitivity in the Guinea Pig

Jl, Turk

doi:10.1159/000229459

Cited by 61 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When comparable doses of several antimetabolites were used, delayed sensitivity to tuberculin, diphtheria toxoid, serum albumin and allergic encephalitis were generally reduced or delayed; however, Salvin and Smith found 6-mercaptopurine ineffective in blocking hypersensitivity to diph theria toxoid in guinea-pigs (15). In contact dermatitis lack of sup pression has been the rule (16), although cyclophosphamide and methotrexate produced temporary suppression in guinea-pigs exposed to several sensitizers including picryl chloride (17). This should not be considered immune intolerance as a demonstrable sensitivity occurred when the drug was stopped.…”

Section: Resultsmentioning

confidence: 99%

Immunologic Responses of Healthy Volunteers Receiving Azathioprine (Imuran)

Maibach

Epstein

1965

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Immunologic Responses of Healthy Volunteers Receiving Azathioprine (Imuran)

Maibach

Epstein

1965

Int Arch Allergy Immunol

View full text Add to dashboard Cite

“…Although we have obtained a clear result only in an obviously self-limited case, it should be also remarked that the dosage adopted in the other, self-perpetuating cases was certainly too low. In view of its spe cific activity on the division of immunoblasts rather than on blastogenesis [56], its use in higher doses, perhaps also in combination with folinic 'res cue' [7], might be warranted.…”

Section: Discussionmentioning

confidence: 99%

Clinical Experiences with Cytotoxic Immunosuppressive Treatment of Idiopathic Thrombocytopenic Purpura

Marmont¹,

Damasio²

1971

Acta Haematol

View full text Add to dashboard Cite

After a review of the literature, a series of 21 patients with ITP treated with non-steroidal immunodepressive agents is presented. The agents were azathioprine (AZP), methotrexate (MTX), cyclophosphamide (CPH), vinblastine (VLB) and L-asparaginase (L-ase). No permanent, unmaintained remission in chronic, self-perpetuating cases of ITP could be obtained, even after splenectomy. However, AZP was useful in the treatment of chronic cases, either alone or in combination with steroids, where it displayed a useful steroid sparing effect. CPH and MTX were generally ineffective. VLB induced striking temporary thrombocytoses, and L-ase was followed by an early thrombocytosis, but proved too toxic to be employed consistently. Single case reports and remission percentages are reported.

show abstract

“…The degree of suppression increased relative to the length of time from the sensitising dose that the DTH reaction was elicited. This change in the suppressive effect of Cy or 6-MP according to whether treatment was given before or after sensitisation with an optimal dose has been seen in small mammals'using several different antigen systems (Turk, 1964(Turk, , 1967Winklestein et al,\912).…”

Section: Discussionmentioning

confidence: 80%