Studies on the interaction between Ag+ and DNA

Hossain, Zahed; Huq, Fazlul

doi:10.1016/s0162-0134(02)00454-3

Cited by 66 publications

(50 citation statements)

References 19 publications

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“…Therefore, the nanometer sized silver material is suggested could enter the nucleus and; thereby, affect the gene expression. Furthermore, this result is similar with the reported DNA damage associated with Ag + metal ion, 24 but the authors did not report the type of gene damage. The zebrafish is a species of vertebrate that live in an aquatic environment and have homologous genes with humans.…”

Section: Discussionsupporting

confidence: 89%

“…The increased DNA damage was believed to be due to the free radicals produced from the oxidation of ascorbate by molecular oxygen, where the Ag + ion played a catalytic role. 24 In this study, exposure to nanometer sized silver caused zebrafish embryos to develop abnormally (Figure 3), which may be due to nanometer sized silver entering the embryo membrane. Ag + ions could bind DNA, resulting in possible DNA damage.…”

Section: Discussionmentioning

confidence: 60%

“…In this study, the antioxidation enzyme catalase activities were increased in the nanometer sized silver exposed groups (10 and 20 ppt). This result, like that of the increased DNA damage, was believed to be due to the free radicals produced, 24 while it is the role of catalase to remove free radicals. The increased catalase activities in the Ag + exposed groups are suggested to be the result of DNA damage due to free radicals.…”

Section: Discussionmentioning

confidence: 92%

“…This may be the cause of the decreased hatching rate observed in the nanometer silver exposed groups in this study. Although anticancer activity is associated with its covalent bonding to the N7 centers of guanine and adenine in DNA, 26 metal ions, including Ag + , could covalently bind with DNA, 24 and the resultant anticancer activity could be affected by metal ion binding. In this study, the antioxidation enzyme catalase activities were increased in the nanometer sized silver exposed groups (10 and 20 ppt).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Nanometer Sized Silver Materials on Biological Toxicity During Zebrafish Embryogenesis

Yeo¹,

Kang

2008

Bulletin of the Korean Chemical Society

104

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Commercial nanometer sized silver is widely used for its antibacterial effect; however, nanoparticles may also have ecotoxicological effects after being discharged into water. Nanometer sized silver can flow into aquatic environments, where it can exert a variety of physiologically effects in living organisms, including fish. The present study aimed to investigate the effect of nanometer sized silver on the development of zebrafish embryos, analyze the properties of commercial nanometer sized silver and define the toxicity relationship between embryogenesis and hatched flies. The commercial nanometer sized silver was analyzed in the Ag + ion form. The hatch rate decreased in the nano-silver exposed groups (10 and 20 ppt); furthermore, the hatched flies had an abnormal notochord, weak heart beat, damaged eyes and curved tail. The expression of the Sel N1 gene decreased in the nano-silver exposed groups, and the catalase activities of the exposed groups increased relative to those in the control group. Therefore, the Ag + ions in commercial nanometer sized silver could accumulate in aquatic environments and seriously damage the development of zebrafish embryos.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Nanometer Sized Silver Materials on Biological Toxicity During Zebrafish Embryogenesis

Yeo¹,

Kang

2008

Bulletin of the Korean Chemical Society

104

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“…Moreover, MIC-AgNPs were also significantly lower than solution of AgNO 3 for all test bacteria. Such impressive effect of AgNPs may be due to interplay with the thiol group of L-cysteine protein residues that may force to enzymatic dysfunction [29] or the AgNPs may have galvanize the release of reactive oxygen species, which lead to destruction of DNA and protein of microorganism [30]. Furthermore, it is found that AgNPs have higher antibacterial activities (Comparatively higher MIC against Gram(+) bacteria) against Gram(-) bacteria may be due to the absence of thick layer of peptidoglycan in cell wall of Gram (-) bacteria [31,32].…”

Section: Minimum Inhibitory Concentration and Minimal Bactericidal Comentioning

confidence: 99%

Synthesis, Characterization and Antimicrobial Activity of Abelia grandiflora Assisted AgNPs

Sharma¹,

Jasuja²,

Rajgovind³

et al. 2014

Microb Biochem Technol

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In past few years, wide applicability of silver nanoparticles (AgNPs) in various field attract for an approach of rapid, cost effective and eco-friendly synthesis of AgNPs that is expanding research toward biological methods. The biosynthesised AgNPs were confirmed visually by appearance of dark brown color formation in mixture and silver surface plasmon resonance band observed at 413 nm by using UV-Visible Spectroscopy A. grandiflora may be used for the green synthesis of ultra-fine nanoparticles of silver for their antimicrobial activities.

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Investigation of Metal Ion Effect on Specific DNA Sequences and DNA Hybridization

Topkaya

Çetin²

2019

Electroanalysis

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In this article, we investigated the sequence specific interaction of single (ssDNA) and double stranded (dsDNA) with silver ions (Ag+) with electrochemical methods. We, for the first time, examined the effect of base sequences, base content and physiochemical properties of different DNA sequences on interaction with Ag+ in detail. We used different base contents to show how the composition of nucleic acid influences the electrochemical signals. We first immobilized ssDNA probes on bare graphite electrodes. Then, we showed the sequence effect on oxidation signals of AgDNA complex by sensing Ag+ to the probe coated surfaces to interact with different ssDNA sequences. Furthermore, we investigated the effect of Ag+ on dsDNA. We measured the oxidation signals obtained from Ag+‐ssDNA and Ag+‐dsDNA complex at approximately 0.2 V and 1.0 V (vs Ag/AgCl), respectively with Differential Pulse Voltammetry (DPV). We showed that the oxidation signals of the AgDNA complex obtained from dsDNA‐modified electrodes is higher than the electrodes modified with ssDNA. More importantly, we showed that Ag+‐ssDNA and Ag+ ion‐dsDNA exhibit different electrochemical behaviors.

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Studies on the interaction between Ag+ and DNA

Cited by 66 publications

References 19 publications

Effects of Nanometer Sized Silver Materials on Biological Toxicity During Zebrafish Embryogenesis

Effects of Nanometer Sized Silver Materials on Biological Toxicity During Zebrafish Embryogenesis

Synthesis, Characterization and Antimicrobial Activity of Abelia grandiflora Assisted AgNPs

Investigation of Metal Ion Effect on Specific DNA Sequences and DNA Hybridization

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