Studies on the immobilization of biofunctional components by radiation polymerization and their applications

Programming control of intelligent drug releases in response to single and binary environmental stimulation signals using sensor and electroresponsive hydrogel

“…In order to construct the intelligent-type DDS, it is necessary to consider both the sensor function to detect the conditional change in the body and the actuator function to regulate the on-off switching of drug release in response to the sensing results (Santini et al, 1999;Langer and Tirrell, 2004;Kami-Ike et al, 1991). The stimuli-responsive polymer hydrogels are interesting materials for this purpose with both sensing and actuating functions (Kaetsu, 1977;Kaetsu et al, 1986).…”