Studies on the human immunoglobulin allotypes in five populations in the USSR

Matsumoto, Hideo; Miyazaki, Tokiko; Rychkov, Yuri G.; Жукова, О. В.; Лебедева, И. А.; Kondik, V. M.; Udina, I. G.; Spitzin, V. A.; Batsuur, J.; Shnader, Y. V.; Tsuji, Kimiyoshi; Takahashi, Takashi; Nakao, Yoshinobu

doi:10.1007/bf01873530

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…During the course of studying these samples, with our aim fixed on Gm genes that characterize Mongoloid populations, we obtained an unexpected result allowing us to approach the roots of Japanese people. 5),6) Based on further cooperative studies with the Russian labs on the dispersal of Mongoloids in Asia, 7) we confirmed the highest frequencies of the Gm ab3st gene among the 3 Buryat populations in the Baikal area; and the geno-cline of Gm ab3st was shown to be in good order, leading to the conclusion that our hypothesis has validtiy.…”

Section: Introductionsupporting

confidence: 63%

The origin of the Japanese race based on genetic markers of immunoglobulin G

Matsumoto

2009

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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This review addresses the distribution of genetic markers of immunoglobulin G (Gm) among 130 Mongoloid populations in the world. These markers allowed the populations to be clearly divided into 2 groups, the northern and southern groups. The northern group is characterized by high frequencies of 2 marker genes, ag and ab3st, and an extremely low frequency of the marker gene afb1b3; and the southern group, in contrast, is indicated by a remarkably high frequency of afb1b3 and low frequencies of ag and ab3st. Based on the geographical distribution of the markers and gene flow of Gm ag and ab3st (northern Mongoloid marker genes) from northeast Asia to the Japanese archipelago, the Japanese population belongs basically to the northern Mongoloid group and is thus suggested to have originated in northeast Asia, most likely in the Baikal area of Siberia.

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Section: Introductionsupporting

confidence: 63%

The origin of the Japanese race based on genetic markers of immunoglobulin G

Matsumoto

2009

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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“…According to Steinberg and Cook (19811, the Gm1,3:5,10,11,13,14,26 haplotype is a typical one for the Mongoloid racial group, in which it occurs in rather high frequencies (cf. Matsumoto, 1988;Matsumoto et al, 1982Matsumoto et al, ,1984. In Asia, however, especially in the northeastern parts of India (Assam), this Mongoloid haplotype was also found among several populations of Caucasoid origin, which suggests that some genetic contact with Mongoloid populations living there had taken place .…”

Section: Methodsmentioning

confidence: 92%

Gm and Km allotypes in four Sardinian population samples

Walter

Matsumoto

Stefano

1991

American J Phys Anthropol

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Serum samples of 683 unrelated male and female individuals of four Sardinian population samples (Sassari, Nuoro, Oristano and Cagliari) were typed for G 1 m (1,2,3,17), G 3 m (5,6,10,11,13,14,15,16,21,26), and Km (1). Phenotype, haplotype (Gm), and allele frequencies (Km), respectively, show a remarkable variability between these four population samples. Comparisons with other Italian populations reveal the considerable genetic difference of the Sardinians, which is in particular caused by the presence of the haplotype Gm1,3;5,10,11,13,14,26 in them. This haplotype is quite uncommon in Europeans and may reflect gene flow from Eastern populations (Phoenicians?) who came to this island in ancient-history times.

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“…Amino acid residue substitutions located at the solvent accessible surface area might be distinguished by specific sera and therefore might be used as markers. Specific markers differing in frequencies within human populations were observed in λand κ-light chains as well as in heavy chains of IgG and IgA (Calderon et al, 2007;Matsumoto et al, 1984;Schanfield et al, 2008). Due to either direct association or linkage disequilibrium with the causative gene, allotypic markers of human immunoglobulin chains could be related to susceptibility of different infectious diseases .…”

Section: Discussionmentioning

confidence: 99%

Organization and transcription analyses of the immunoglobulin genes in cattle and horses

Walther¹

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The third study aimed to gain more insight into the combinatorial diversity, somatic hypermutations and putative gene conversions of IgG in the four cattle breeds Aubrac, German Simmental, German Black Pied, and Holstein Friesian. For the more detailed analysis of rearranged bovine heavy chain immunoglobulin variable regions, a new bioinformatics framework was developed by combining and refining widely used alignment algorithms. Immunoglobulin heavy chains possessing exceptionally long CDR3Hs can now be analyzed specifically, as well as the dominantly transcribed IGHV, IGHD, and IGHJ segments and their recombination.The use of 15 different IGHV segments, 21 IGHD segments, and 2 IGHJ segments was investigated with significant different transcription levels within the breeds. There are preferred rearrangements within the 3 groups of CDR3H lengths. In sequences of group 1 (≤10 aa) and 3 (≥48 aa) a lower number of recombinations were observed than in sequences of group 2 (11-47 aa). The combinatorial diversity revealed 162 significantly different rearrangements of germline IGHV, IGHD, and IGHJ segments.The few preferably rearranged gene segments within group 3 CDR3H regions are supposed to indicate specialized antibodies because this length is unique in cattle.The main result of this study enabled by the new bioinformatics framework, is the strong evidence for gene conversion as a rare event using pseudogenes fulfilling all definitions for this particular diversification mechanism.In conclusion, this thesis contributes to a more detailed understanding of the expressed immunoglobulin repertoire in cattle and horses. Breed and husbandry conditions are supposed to influence the repertoire significantly. This thesis also highlights that the bovine heavy chain diversity is not restricted to the use of a limited number of germline genes although there are preferred rearrangements within the three groups of CDR3H lengths. These results will be of future importance in analyzing seroconversion data after infection or vaccination, as well as determining breed specific differences to select healthy, robust animals.

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Studies on the human immunoglobulin allotypes in five populations in the USSR

Cited by 8 publications

References 9 publications

The origin of the Japanese race based on genetic markers of immunoglobulin G

The origin of the Japanese race based on genetic markers of immunoglobulin G

Gm and Km allotypes in four Sardinian population samples

Organization and transcription analyses of the immunoglobulin genes in cattle and horses

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