Gm and Km allotypes in four Sardinian population samples

Walter, H.; Matsumoto, Hideo; Stefano, G. F. De

doi:10.1002/ajpa.1330860104

Cited by 8 publications

(5 citation statements)

References 16 publications

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“…Phoenician traders spread across the Mediterranean and established major cities and colonies that harbored their pathologic or polymorphic gene variations. 55-58 Among the pathologic gene variations that could have followed Phoenician footsteps are (1) the IVS-I-110 (c.93-21G>A) beta-globin gene mutation, the most frequently encountered beta-thalassemia mutation among Arabs, and (2) the p.G542X mutation in the CFTR gene, a frequently observed cystic fibrosis mutation in the Mediterranean basin. 56,59 Results of the Genographic Consortium from Y-chromosome variations indicate that as many as 1 in 17 men living today on the coasts of North Africa and southern Europe may have a Phoenician direct male-lineage ancestry.…”

Section: Major Events In Ancient Historymentioning

confidence: 99%

Arab gene geography: From population diversities to personalized medical genomics

Tadmouri

Sastry

Chouchane

2014

Global Cardiology Science and Practice

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Genetic disorders are not equally distributed over the geography of the Arab region. While a number of disorders have a wide geographical presence encompassing 10 or more Arab countries, almost half of these disorders occur in a single Arab country or population. Nearly, one-third of the genetic disorders in Arabs result from congenital malformations and chromosomal abnormalities, which are also responsible for a significant proportion of neonatal and perinatal deaths in Arab populations. Strikingly, about two-thirds of these diseases in Arab patients follow an autosomal recessive mode of inheritance. High fertility rates together with increased consanguineous marriages, generally noticed in Arab populations, tend to increase the rates of genetic and congenital abnormalities. Many of the nearly 500 genes studied in Arab people revealed striking spectra of heterogeneity with many novel and rare mutations causing large arrays of clinical outcomes. In this review we provided an overview of Arab gene geography, and various genetic abnormalities in Arab populations, including disorders of blood, metabolic, circulatory and neoplasm, and also discussed their associated molecules or genes responsible for the cause of these disorders. Although studying Arab-specific genetic disorders resulted in a high value knowledge base, approximately 35% of genetic diseases in Arabs do not have a defined molecular etiology. This is a clear indication that comprehensive research is required in this area to understand the molecular pathologies causing diseases in Arab populations.

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Section: Major Events In Ancient Historymentioning

confidence: 99%

Arab gene geography: From population diversities to personalized medical genomics

Tadmouri

Sastry

Chouchane

2014

Global Cardiology Science and Practice

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“…Among European populations, the people of the Mediterranean island of Sardinia constitute an example of genetic isolation, as demonstrated by the well-documented uniqueness of their gene frequencies (Modiano et al, 1986;Piazza et al, 1989a,b;Walter et al, 1991;Vona et al, 1992). Many studies have established numerous genetic, demographic and linguistic peculiarities of Sardinians (Griffo, 1988).…”

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confidence: 96%

Genetic data on Alghero population (Sardinia): Contrast between biological and cultural evidence

Moral

Marogna²,

Salis

et al. 1994

American J Phys Anthropol

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Data on 20 genetic polymorphisms (61 alleles) in the Algehero population on the northwestern coast of Sardinia are presented and discussed in relation to its linguistic peculiarity inside the island. Since the Aragonese (Spain) conquest of Sardinia in the 13th century, the Catalan language, the same as that spoken in Northeastern Spain and certain districts of Southern France, has been used in Alghero even until today. Analysis for heterogeneity of gene frequency distributions indicates that the genetic information obtained on Alghero is adequate to discriminate Sardinians from other neighbouring populations. Genetic variation between populations measured through genetic distances and principal-component analysis shows that the present-day population of Alghero is much closer genetically to Sardinians than to Catalonians. Our genetic results do not support any interpretation of the linguistic affinities between Alghero and Catalonia at present as indicative of biological kinship.

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“…An important feature of Sardinia is the high genetic heterogeneity within the island itself due to geographical andor cultural fragmentation into numerous isolates (Moroni et al, 1972;Workman et al, 1975;Vona, 1980, 1984;Piazza et al, 1985;Modiano et al, 1986;Griffo et al, 1988;Ulizzi et al, 1988;Floris-Masala et al, 1989;Gatti, 1990;Marini, 1990;Succa et al, 1990;Gruppioni et al, 1991;Walter et al, 1991;Contu et al, 1992;Vona et al, 1992;Morelli, 1993;Brasili Gualandi et al, 1994;Moral et al, 1994).…”

mentioning

confidence: 97%

Genetics, geography, and culture: The population of S. Pietro Island (Sardinia, Italy)

Vona

Calò

Lucia

et al. 1996

Am. J. Phys. Anthropol.

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An interesting aspect of the island of Sardinia (Italy) is the wide range of genetic variability within the island itself. The variability is widened by the presence of some populations of different ethnic origin who speak a language other than Sardinian. This work deals with the study of the genetic structure of the Carloforte population which inhabits the tiny island of S. Pietro 4 km off the southwest coast of Sardinia. S. Pietro was first populated in 1738 by emigrants coming from the island of Tabarka (Tunisia) who spoke an archaic form of the Ligurian dialect. Data on genetic polymorphisms in the Carloforte population are presented and discussed in relation to some Sardinian and Italian populations. Data on demographic and matrimonial structure are also presented. The genetic analyses show the Carloforte population as being clearly separated from both Sardinians and continental Italians. The isolation of Carloforte, highlighted by language diversity, endogamy, and consanguinity levels and marriage area, supports the idea of genetic diversity linked to cultural peculiarity.

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Gm and Km allotypes in four Sardinian population samples

Cited by 8 publications

References 16 publications

Arab gene geography: From population diversities to personalized medical genomics

Arab gene geography: From population diversities to personalized medical genomics

Genetic data on Alghero population (Sardinia): Contrast between biological and cultural evidence

Genetics, geography, and culture: The population of S. Pietro Island (Sardinia, Italy)

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