Studies on the folic acid vitamins.I. Observations on the metabolism of folic acid in man and on the effect of aminopterin

Condit, Paul T.; Grob, David

doi:10.1002/1097-0142(195805/06)11:3<525::aid-cncr2820110311>3.0.co;2-8

Cited by 26 publications

(13 citation statements)

References 23 publications

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“…In blood, as well, there is no definite evidence for a specific folate binder. When folic acid is added to serum, the per cent bound remains fairly constant over a wide concentration range (5), the binding is reversible (6), and the bound vitamin can easily be extracted with charcoal (7).…”

Section: Introductionmentioning

confidence: 99%

Further observations on the folate-binding factor in some leukemic cells

Rothenberg¹,

DaCosta²

1971

J. Clin. Invest.

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Section: Introductionmentioning

confidence: 99%

Further observations on the folate-binding factor in some leukemic cells

Rothenberg¹,

DaCosta²

1971

J. Clin. Invest.

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“…Attention was also focused on the part played by subfraction I V-4. Condit and Grob (1958) found that the electrophoretic mobility of folic acid activity was greater than that of albumin. The same result was reported later by Elsborg (1972).…”

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confidence: 99%

Serum folic acid activity(L. casei)in Sephadex gel chromatography

Markkanen¹,

Pajula²,

Himanen³

et al. 1973

J Clin Pathol

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The total folic acid activity of the serum in health and in various diseases of man has been extensively discussed in the medical literature. These reports have almost completely neglected the possibility of folic acid activity being bound to the serum proteins. However, Toennies, Usdin, and Phillips (1956) found in their studies that the plasma factor was present in the Cohn fractions IV + V of the plasma. It was also present in the glycoproteins, lipoproteins, mucoproteins, and other special proteins. Attention was also focused on the part played by subfraction I V-4. Condit and Grob (1958) found that the electrophoretic mobility of folic acid activity was greater than that of albumin. The same result was reported later by Elsborg (1972). Johns, Sperti, and Burgen (1961) considered there was little or no free folic acid activity in the fasting plasma. Injected tritiumlabelled folic acid activity in plasma was 64 % protein-bound. Neal and Williams (1965) added tritiated folic acid to rat serum and studied its behaviour in electrophoresis. Folic acid activity migrated towards the anode faster than albumin and only small amounts of radioactivity were found in the protein fractions. Unbound folic acid activity was found to run in advance of the albumin, occupying a similar zone to that of natural folate. Traces of

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“…Serum is known to be a poor binder of pteroylmonoglutamic acid (PGA) (Condit and Grob, 1958;Hampers, Streiff, Nathan, Snyder, and Merrill, 1967;Metz, Zaluisky, and Herbert, 1968) but serum binding of natural endogenous folate has been scantily studied (Markkanen, 1968).…”

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confidence: 99%

Folate binders in body fluids

Retief

Huskisson

1970

J Clin Pathol

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SYNOPSIS In normal serum, saline dialysis for 48 hours in Visking casing resulted in folate clearance closely comparable to that produced by haemoglobin-coated charcoal adsorption, except in kwashiorkor where charcoal removed a greater proportion of folate. Pre-and post-dialysis values probably represented total and bound folate, respectively. Urinary folate consisted almost exclusively of dialyzable or free folate. Folate in saliva, bile, and erythrocytes consisted of dialyzable and non-dialyzable fractions; gastric juice contained minimal amounts of folate.

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Studies on the folic acid vitamins.I. Observations on the metabolism of folic acid in man and on the effect of aminopterin

Cited by 26 publications

References 23 publications

Further observations on the folate-binding factor in some leukemic cells

Further observations on the folate-binding factor in some leukemic cells

Serum folic acid activity(L. casei)in Sephadex gel chromatography

Folate binders in body fluids

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