Studies on the evolution and function of different forms of the mouse myogenic gene Myo-D1 and upstream flanking region

Kay, Peter; Marlow, S.A.; Mitchell, Christopher A.; Papadimitriou, J. M.

doi:10.1016/0378-1119(93)90396-k

Cited by 12 publications

(3 citation statements)

References 25 publications

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“…Myoblast proliferation during early embryonic development is controlled by myf3 and myf5 genes ( Kay 1993) . However slight differences in expression pattern between myf5 and myf3 were observed.…”

Section: Discussionmentioning

confidence: 99%

Restriction fragment length polymorphisms in myogenin and myf3 genes and their influence on lean meat content in pigs

Cieslak

Kapelański

Blicharski

et al. 2000

J Animal Breeding Genetics

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A total of 120 pigs from farm I and 109 from farm II were examined for DdeI polymorphism in myf3 and for MspI polymorphism in myogenin genes. Meatness, weight and ratio of ham and loin meat, and loin eye area of animals with different genotypes for myf3 and for myogenin were compared. In myf3 polymorphism pigs A/A from farm I displayed significantly lower values for these characteristics. In farm II there was a reverse tendency. Present results indicate that the DdeI polymorphic region in porcine myf3 gene does not influence functionality of this gene but it may point at another polymorphism located nearby and being of functional importance. Two regions of the porcine myogenin gene were analysed for MspI polymorphism. The region encompassing coding sequences (MYOG1) was polymorphic only in three Pietrain pigs (out of 150 individuals tested) making it useless for assessment of meat productivity in pigs. The 3′ untranslated region was polymorphic and the frequency of 4.2 and 4.9 alleles varied among breeds. The 4.2 variant was predominant in Pietrain pigs. Statistical analysis indicated that meat, ham and loin meat percentages as well as loin eye area were significantly higher in 4.2/4.2 homozygotes. Further study will be undertaken to explain the relations between meat productivity and myf3 and MYOG2 alleles within breed.

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Section: Discussionmentioning

confidence: 99%

Restriction fragment length polymorphisms in myogenin and myf3 genes and their influence on lean meat content in pigs

Cieslak

Kapelański

Blicharski

et al. 2000

J Animal Breeding Genetics

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“…The underlying mechanisms for such strain differences are unclear, but the correlation between regeneration capacity and genetic background suggests the involvement of modifier genes. Differential expressions of Pax7 isoforms and MyoD have been correlated with efficiency of repair (165)(166)(167)197). Furthermore, expression levels of basic fibroblast growth factor (FGF) have been correlated with the efficiency of repair within Balb/c and SJL/J muscles (10).…”

Section: Animal Models Of Muscle Injurymentioning

confidence: 99%

Cellular and Molecular Regulation of Muscle Regeneration

Chargé¹,

Rudnicki²

2004

Physiological Reviews

2,249

2,136

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Under normal circumstances, mammalian adult skeletal muscle is a stable tissue with very little turnover of nuclei. However, upon injury, skeletal muscle has the remarkable ability to initiate a rapid and extensive repair process preventing the loss of muscle mass. Skeletal muscle repair is a highly synchronized process involving the activation of various cellular responses. The initial phase of muscle repair is characterized by necrosis of the damaged tissue and activation of an inflammatory response. This phase is rapidly followed by activation of myogenic cells to proliferate, differentiate, and fuse leading to new myofiber formation and reconstitution of a functional contractile apparatus. Activation of adult muscle satellite cells is a key element in this process. Muscle satellite cell activation resembles embryonic myogenesis in several ways including the de novo induction of the myogenic regulatory factors. Signaling factors released during the regenerating process have been identified, but their functions remain to be fully defined. In addition, recent evidence supports the possible contribution of adult stem cells in the muscle regeneration process. In particular, bone marrow-derived and muscle-derived stem cells contribute to new myofiber formation and to the satellite cell pool after injury.

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“…It is still unclear whether this polymophism could be related to different muscle growth potentials and be used as a marker within selection lines of one breed. Furthermore, K ay et al (1993) reported three different MyoD (myf‐3) alleles (detected with RFLP patterns with four different restriction enzymes) in different mouse strains, one of which seems to be associated with higher efficiency of skeletal muscle regeneration following muscle injury.…”

Section: Muscle Tissue Developmentmentioning

confidence: 99%

Genetic regulation of meat production by embryonic muscle formation – a review

Pas¹,

Visscher²

1994

J Animal Breeding Genetics

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The biological basis for meat production in livestock animals is localized in the muscles, where lean meat production is under the genetic control of tissue-specific and more ubiquitously operating genes. The muscle tissue-specific MyoD gene family is at the centre of the genetic regulation of myoblast proliferation and differentiation into myofibres. The regulation of embryonic muscle tissue formation (development) by the MyoD genes is duscussed in the context of livestock animals used in meat production. The possibility that the MyoD genes could be useful candidate genes for breeding is discussed. It is concluded that marker assisted selection (MAS) using markers in functional genes is advantageous over MAS using associated markers. ZUSAMMENFASSUNG: Genetische Regulierung der Fleischproduktion bei der embryonalen Muskelbildung - Ein Literaturüberblick Die biologische Grundlage für Fleischproduktion, lokalisiert in den Muskeln, steht unter genetischer Kontrolle durch gewebsspezifische una mehr ubiquitär arbeitende Gene. Die gewebsspezifische MyoD Genfamilie in den Muskeln befindet sich im Zentrum der genetischen Regulierung des Prozesses der Myoblastteilung und Differenzierung zu Myofasern. Die Ubersicht betrifft Regulierung der Bildung des embryonalen Muskelgewebes (Entwicklung) mit Hilfe der MyoD Gene. Die Möglichkeit, daß MyoD Gene erfolgreiche Kandidatengene für Tierzüchtung sein können, wird besprochen. 'Marker-assisted selection' (MAS) mit Hilfe von Markern funktioneller Gene sollte vorteilhafter sein als MAS mit gekoppelten DNA-Sequenzen. RÉSUMÉ: Régulation génétique de la production de viande par la formation embryologique des muscles - un résumé La base biologique de la production de viande dans les animaux d'élevage se situe dans les muscles, là où la production de viande maigre est sous contrôle génétique de gènes générals et tissu-spécifiques. La famille des gènes muscle-spécifiques MyoD forme le centre de la régulation des procès de prolifération des myoblastes et de différenciation vers les myofibres. Le but de cet article rétrospectif est de situer la discussion sur la régulation de la formation embryologique des muscles par les gènes MyoD dans le cadre de l'élevage. La possibilité que les gènes MyoD soient des gènes candidats utiles pour l'élevage sera discutée. La conclusion faite est que 'marker assisted selection' (MAS) en employant des marquers situés dans des gènes fonctionnels a plus d'avantages que MAS avec des marquers associés.

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Studies on the evolution and function of different forms of the mouse myogenic gene Myo-D1 and upstream flanking region

Cited by 12 publications

References 25 publications

Restriction fragment length polymorphisms in myogenin and myf3 genes and their influence on lean meat content in pigs

Restriction fragment length polymorphisms in myogenin and myf3 genes and their influence on lean meat content in pigs

Cellular and Molecular Regulation of Muscle Regeneration

Genetic regulation of meat production by embryonic muscle formation – a review

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