Studies on the Etiology of Marek's Disease. II. Finding of a Herpesvirus in Cell Culture

Nazerian, K.; Solomon, J. J.; Witter, R. L.; Burmester, B. R.

doi:10.3181/00379727-127-32650

Cited by 178 publications

(58 citation statements)

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“…Previous investigations have provided strong evidence that a herpes-type virus is the cause of Marek's disease (Churchill & Biggs, 1967;Solomon et al 1968;Nazerian et al 1968;Churchill & Biggs, 1968;Biggs et al i969).…”

Section: Introductionmentioning

confidence: 99%

The Attenuation, with Loss of Oncogenicity, of the Herpes-type Virus of Marek's Disease (Strain hprs-16) on Passage in Cell Culture

Churchill

Chubb

Baxendale

1969

Journal of General Virology

238

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SUMMARYThe herpes-type virus of Marek's disease showed a gradual increase in the rate of development of cytopathic effect on passage in cell culture. By the 6oth passage macroscopic plaques were produced after 6 days under fluid overlay, but no cell-free virus could be recovered after filtration of culture medium.A loss of pathogenicity for chicks was noticed in the virus after 33 passages in cell culture. Furthermore, an antigenic change occurred between the 2oth and 3oth passage which was characterized by the loss of an antigen which could normally be found in the supernatant medium of cultures infected with low passage virus.The possible origin of the attenuated virus is discussed.

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Section: Introductionmentioning

confidence: 99%

The Attenuation, with Loss of Oncogenicity, of the Herpes-type Virus of Marek's Disease (Strain hprs-16) on Passage in Cell Culture

Churchill

Chubb

Baxendale

1969

Journal of General Virology

238

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“…In 1967, the first isolation of MDV was successfully achieved [13,47], Marek's disease (MD) is a highly contagious malignant lymphoma of chicken caused by Marek's disease virus (MDV). Infected chickens are depressed, and many clinical signs including dullness, squat down and inverse feathers with progression of lymphoma development and paralysis or ataxia if lymphoma/lymphoblast cells infiltrate in peripheral nerves are observed [53].…”

Section: Marek's Disease Vaccinesmentioning

confidence: 99%

Pathogenesis of Marek's Disease(MD) and Possible Mechanisms of Immunity Induced by MD Vaccine.

et al. 1998

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ABSTRACT. Marek's disease (MD) is a lymphoproliferative disease of chicken, which is characterized by malignant T cell-lymphoma formation. This disease can be effectively prevented by vaccination with attenuated MD virus (MDV), apathogenic MDV or herpesvirus of turkey. MD vaccines are ones of a few vaccines which can prevent virus-induced tumor among mammalian and avian species. To determine the roles of T cell subsets in the protection mechanism, chickens vaccinated with an attenuated MDV (CVI988) were depleted of either CD4 + or CD8 + T cells by neonatal thymectomy and injections of monoclonal antibodies against chicken CD4 or CD8 molecules and then challenged with an oncogenic MDV. These birds were effectively protected from MDV-induced tumors. However, virus titers in CD4 + T cells, which are the main target cells for MDV-latent infection and subsequent transformation, were much higher in CD8-deficient vaccinated chickens than in untreated vaccinated chickens at the early stage of the latent phase. These results suggested that CD8 + T cell responses induced by the MD vaccine are essential for anti-virus but not anti-tumor effects. Here, we will discuss how the attenuated vaccine prevents chickens from lymphoma-formation by an oncogenic MDV. -KEY WORDS: apoptosis, Marek's disease, Marek's disease virus, vaccine.

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“…This has been evidenced by demonstrating the presence of both immunoglobulin M (IgM) and B-cell antigenic markers on the surface of virtually all tumour cells (Cooper et al, 191'4;Payne and Rennie, 1975). In contrast, MD is essentially a malignancy of the thymic (T) system of lymphocytes, caused by a herpesvirus (Churchill and Biggs, 1967;Nazerian et al, 1968;Solomon et al, 1968). MD lymphomas consist mainly of T-cells with only a small population of B-cells (Hudson and Payne, 1973;Rouse et al, 1973;Payne et al, 1974;Payne and Rennie, 1976).…”

Section: Introductionmentioning

confidence: 99%

Demonstration of immunoglobulin m on avian lymphoid leukosis lymphoma cells by the unlabelled antibody peroxidase‐antiperoxidase method

Drén

Németh²

1987

Avian Pathology

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Studies on the Etiology of Marek's Disease. II. Finding of a Herpesvirus in Cell Culture

Cited by 178 publications

References 0 publications

The Attenuation, with Loss of Oncogenicity, of the Herpes-type Virus of Marek's Disease (Strain hprs-16) on Passage in Cell Culture

The Attenuation, with Loss of Oncogenicity, of the Herpes-type Virus of Marek's Disease (Strain hprs-16) on Passage in Cell Culture

Pathogenesis of Marek's Disease(MD) and Possible Mechanisms of Immunity Induced by MD Vaccine.

Demonstration of immunoglobulin m on avian lymphoid leukosis lymphoma cells by the unlabelled antibody peroxidase‐antiperoxidase method

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