Pathogenesis of Marek's Disease(MD) and Possible Mechanisms of Immunity Induced by MD Vaccine.

Morimura, Toshifumi; Ohashi, Kazuhiko; Sugimoto, Chihiro; Onuma, Misao

doi:10.1292/jvms.60.1

Cited by 59 publications

(38 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pathogenesis of MD can be sequentially divided into three phases: early cytolytic infection; latent infection; and secondary cytolytic infection with immunosuppression and tumor development [6,18,26]. The activation of T cells during the cytolytic infection is important for the establishment of the latency which starts at 1-2 weeks after the infection, since the latent infection of MDV is maintained in activated T cells [3,4].…”

mentioning

confidence: 99%

The Detection of the meq Gene in Chicken Infected with Marek's Disease Virus Serotype 1.

et al. 2002

Self Cite

View full text Add to dashboard Cite

ABSTRACT. In the genome of strains of very virulent Marek's disease virus serotype 1(vvMDV1), such as Md5 and RB1B, the meq open reading frame (ORF) encoding a 339-amino-acid bZIP protein, is present, while a slightly longer meq ORF, termed as L-meq, in which a 180-bp sequence is inserted into the meq ORF is found in other strains of MDV1, such as CVI988/R6 and attenuated JM. When chickens were infected with vvMDV1 strains and the meq gene was amplified by nested polymerase chain reaction (PCR), the meq gene was detected throughout the experimental period for 7 weeks post inoculation (pi). However, the L-meq gene was also detected at 3 to 5 weeks and 3 to 4 weeks pi. in Md5-infected and RB1B-infected chickens, respectively. In the case of chickens infected with an attenuated MDV1, the JM strain, the L-meq gene was detected at 2 to 7 weeks pi., and the meq gene was also detected at 2 to 6 weeks pi. Both L-meq and meq genes were detected in chickens infected with an attenuated nononcogenic vaccine strain of MDV1 (CVI988/R6), throughout the experimental period. Though quantitative PCR was not performed, a larger amount of the PCR products corresponding to the L-meq than the meq gene was amplified from chickens infected with JM or CVI988/R6. These results suggest that a dynamic population shift between the MDV subpopulations displaying meq and L-meq genes occurs in chickens during the course of MDV infection. Since the MDV subpopulation that displays the L-meq gene only displays it during the latent phase, the L-meq and its gene product, if any, might contribute to the maintenance of the MDV latency.

show abstract

mentioning

confidence: 99%

The Detection of the meq Gene in Chicken Infected with Marek's Disease Virus Serotype 1.

et al. 2002

Self Cite

View full text Add to dashboard Cite

show abstract

“…Konsekwencją replikowania się zjadliwego wirusa terenowego oraz jego rozprzestrzeniania się wśród innych ptaków jest również pojawienie się szczepów o zdolnościach do przełamywania odporności poszczepiennej. Wynika to z presji selekcyjnej wywieranej na szczepy terenowe (28).…”

Section: Szczepieniaunclassified

Applying the isothermal DNA amplification method in identifying the Marek’s disease virus in poultry

Józefiak¹,

Kufel²,

Wilczyński³

2017

Medycyna Weterynaryjna

View full text Add to dashboard Cite

SummaryMarek's disease is a viral disease, a type of poultry cancer. It is caused by MDV serotype 1 (Marek's disease virus, MDV) viruses, also referred to as Gallid herpesvirus 2 belonging to the family Herpesviridae. The complete, fully infectious virus particles are present in the feathers and the nodules months can survive in the environment for many months. The use of isothermal amplification methods of genetic material (LoopMediated Isothermal Amplification, LAMP) virus MDV enables rapid and precise identification of the virus in difficult diagnostic material, including dust. By optimizing the reaction conditions and using at least two pairs of primers which bind to specific sites in the genome of the virus, this technique has high sensitivity and specificity. The technique makes it possible to detect of single copies of the meq oncogene -a unique region of DNA of the first type of virus MDV.

show abstract

“…장형관 등 : 최근 진화하는 마렉병의 원인 분석 302 (Morimura et al, 1998;Baaten et al, 2004 현성으로 경과하기 때문이다 (Hu, 1992;Hu et al, 1993;Jeurissen et al, 1992;McConnell et al, 1993a,b;Otaki et al, 1992;Yuasa et al, 1980). …”

unclassified

Evolving Problem Analyses of Recent Marek's Disease

Jang

Park²,

Cha³

et al. 2007

Korean Journal of Poultry Science

View full text Add to dashboard Cite

Marek's disease (MD) is a highly contagious lymphoproliferative disease of poultry caused by the oncogenic herpesvirus designated Marek's disease virus (MDV). MD has a worldwide distribution and is thought to cause an annual loss over US$ one billion to the poultry industry. Originally described as a paralytic disease, today MD is mostly manifested as an acute disease with tumors in multiple visceral organs. MD is controlled essentially by the widespread use of live vaccines administered either in ovo into 18-day-old embryos or into chicks immediately after they hatch. In spite of the success of the vaccines in reducing the losses from the disease in the last 30 years, MDV strains have shown continuous evolution in virulence acquiring the ability to overcome the immune responses induced by the vaccines. During this period, different generations of MD vaccines have been introduced to protect birds from the increasingly virulent MDV strains. However, the virus will be countered each new vaccine strategy with ever more virulent strains. In spite of this concern, currently field problem from MD is likely to be controled by strategy of using bivalent vaccine. But, potential risk factors for outbreak of MD are still remained in this condition. The major factors can be thought that improper handling and incorrect administration of the vaccine, infection prior to establishment of immunity, suppression of immune system by environmental stress and outbreaks of more virulent MDV strain by using vaccine and genetic resistance of host.

show abstract

Pathogenesis of Marek's Disease(MD) and Possible Mechanisms of Immunity Induced by MD Vaccine.

Cited by 59 publications

References 82 publications

The Detection of the meq Gene in Chicken Infected with Marek's Disease Virus Serotype 1.

The Detection of the meq Gene in Chicken Infected with Marek's Disease Virus Serotype 1.

Applying the isothermal DNA amplification method in identifying the Marek’s disease virus in poultry

Evolving Problem Analyses of Recent Marek's Disease

Contact Info

Product

Resources

About