Studies on the Epidemiology of Escherichia coli Infections. IV. Evidence for a Nosocomial Flora*

Kennedy, Roger P.; Plorde, James J.; Petersdorf, Robert G.

doi:10.1172/jci105134

Cited by 49 publications

(18 citation statements)

References 20 publications

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“…A number of investigations have shown that only a few serological types of E. coli are responsible for most coliform infections (e.g. Turck, Petersdorf & Fournier, 1962;Kennedy, Plorde & Petersdorf, 1965). Much of this work has concentrated on urinary infection but our investigation suggests that in terminal bronchopneumonia there may be a high proportion of infections by certain serotypes (06, 075 and 018).…”

Section: Pneumonic Lesions Absentmentioning

confidence: 67%

“…Much of this work has concentrated on urinary infection but our investigation suggests that in terminal bronchopneumonia there may be a high proportion of infections by certain serotypes (06, 075 and 018). Kennedy et al (1965) and Winterbauer, Turck & Petersdorf (1967) found that types 04, 06 and 075 occur more frequently in the faeces of patients and staff in hospital and the carrier rate among patients was directly related to the time spent in hospital; inanimate objects in the wards were rarely contaminated and they therefore suggested that antibiotic treatment or other factors present in hospital patients might encourage spread from the endogenous bowel flora. Since, however, 40 % of the hospital staff in their study were carrying these serotypes there would seem to have been ample opportunity for transmission by direct personal contact.…”

Section: Pneumonic Lesions Absentmentioning

confidence: 99%

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Terminal bronchopneumonia. A bacteriological and histological study of 111 necropsies

Tanner

Gray

Rebello

et al. 1969

J. Hyg.

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SUMMARYOne hundred and eleven consecutive deaths in seven mental hospitals during the months of February to October 1967 were investigated histologically and bacteriologically.Bacteria were present in the lung tissue significantly more frequently when inflammation was present than when it was absent and the differences were significant for both Escherichia coli and Staphylococcus aureus; E. coli was isolated from 22(34%) of the 65 patients with inflamed lungs compared with two (4%) of 46 control patients and the corresponding figures for Staph. aureus were 20(31%) of 65 patients compared with seven (15%) of 46 control patients.Some strains of E. coli were serotyped using antisera against 0 antigens 1, 4, 6, 18ab, 18ac, 25, 50, 65, 69 and 75 and the strains most commonly found in the inflamed lungs, spleens and other inflammatory lesions of 25 patients were 06, 018 and 075. These strains were isolated more frequently from these sites than from the faeces of a group of 19 patients with no such lesions.In this series E. coli was the commonest organism to be associated with terminal bronchopneumonia and the possible reasons for this are discussed.

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Section: Pneumonic Lesions Absentmentioning

confidence: 67%

Section: Pneumonic Lesions Absentmentioning

confidence: 99%

Terminal bronchopneumonia. A bacteriological and histological study of 111 necropsies

Tanner

Gray

Rebello

et al. 1969

J. Hyg.

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“…In the survey of inanimate objects and in patients with bacteriuria, gram-negative organisms other than E. coli also were identified. The scheme in use in this laboratory for identification of these organisms has been described previously (4). The number of organisms in all urine cultures was quantitated by serial dilution and 10' bacteria per ml was defined as connoting significant bacteriuria.…”

Section: Methodsmentioning

confidence: 99%

“…These studies demonstrated increased intestinal colonization by E. coli serogroups 04, 06, and 075 during and after hospitalization (4). The tendency to become colonized with strains in these o groups was directly related to the duration of hospitalization, and patients who were in the hospital 3 weeks or longer had an intestinal carrier rate of 60%o' compared to a rate of only 15% in individuals who had had no recent hospital contact.…”

Section: Introductionmentioning

confidence: 92%

Studies on the Epidemiology of Escherichia coli Infections. V. Factors Influencing Acquisition of Specific Serologic Groups*

Winterbauer¹,

Turck²,

Petersdorf³

1967

J. Clin. Invest.

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Summary. Stool carrier rates of Escherichia coli serogroups 4, 6, and 75 were determined on admission and discharge for 190 patients. Persons who were in the hospital 3 weeks or longer had an intestinal carrier rate of 46% compared to a rate of 28% in individuals who had no recent hospital contact. Treatment with broad spectrum antibiotics increased the susceptibility for acquisition of certain specific serologic groups. This was apparently not related to replacement of sensitive E. coli by drug-resistant forms. Studies were made to determine the environmental source for colonization of hospitalized patients and the risk of urinary infection in stool carriers of these strains. A survey of inanimate objects of medical and urological wards demonstrated infrequent isolation of 04, 06, and 075, indicating that extraintestinal foci were an unlikely source for hospital-acquired E. coli. Hemagglutination titers with determination of group-specific 0 antibody failed to demonstrate any deficiency in hospitalized patients who became colonized with certain coliforms. Similarly, no significant deficit in group-specific serum antibody was found in patients who were community carriers of E. coli 04, 06, or 075. Despite a high rate of acquisition of E. coli serogroups 4, 6, and 75 in the stools of hospitalized patients, only those patients undergoing urinary tract manipulation developed bacteriuria.

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“…Não nos preocupamos com a identificação mais específica dos microrganismos isolados, a não ser com o estafilococo, porquanto, através de numerosos trabalhos (Kennedy e col. 21 , Spencer e col. 46 , Cooke e col. 8 , Shooter e col. 44,45 , Weil e col. 53 , Dans e col. 9 , Falcão e col.…”

Section: Antibiogramaunclassified

Infecções hospitalares no município de Araraquara, SP (Brasil)

et al. 1976

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Foi demonstrada a etiologia das infecções adquiridas em hospitais da cidade de Araraquara, S. Paulo, Brasil, verificando-se o comportamento das bactérias isoladas frente a 10 antimicrobianos. A metodologia bacteriológica seguida conduziu à especiação bacteriana, com exceção do estafilococos que foi identificado através da fagotipagem. Dos 171 processos infecciosos, adquiridos nos hospitais no período de setembro de 1974 a maio de 1975, foram isolados 211 microrganismos, sendo 73,0% de bactérias Gram negativas e 27,0% de bactérias Gram positivas. Verificou-se um alto nível de resistência à maioria dos antibióticos. As bactérias Gram negativas apresentaram menor resistência à Gentamicina (22,2%), enquanto as Gram positivas apresentaram menor resistência à Cefalotina (17,7%), à Fosfomicina (25,5%) e à Gentamicina (29,4%). Os resultados permitiram antever sérias dificuldades quanto à ação dos antimicrobianos sobre as bactérias, assim como a intensa disseminação das bactérias Gram negativas, especialmente a Escherichia coli e as Pseudomonas.

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Studies on the Epidemiology of Escherichia coli Infections. IV. Evidence for a Nosocomial Flora*

Cited by 49 publications

References 20 publications

Terminal bronchopneumonia. A bacteriological and histological study of 111 necropsies

Terminal bronchopneumonia. A bacteriological and histological study of 111 necropsies

Studies on the Epidemiology of Escherichia coli Infections. V. Factors Influencing Acquisition of Specific Serologic Groups*

Infecções hospitalares no município de Araraquara, SP (Brasil)

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