Studies on the effect of experimental hyperthyroidism on the adult frog, Rana pipiens, schreber

Warren, Marshall R.

doi:10.1002/jez.1400830106

Cited by 40 publications

(3 citation statements)

References 26 publications

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“…However, results obtained from measurement of respiration after injection of thyroxine into the living animal appear to be contra¬ dictory, for whereas Warren (1940) using intact adult frogs (Rana pipiena) reported increased oxygen consumption, Galton & Ingbar (1962) found that thyroxine caused no alteration in the respiration rate of frog-tissue slices.…”

Section: Discussionmentioning

confidence: 95%

Permeability and Respiration Effects of Thyroidal Hormones on the Isolated Bladder of the Toad Bufo Bufo

Matty¹,

Green²

1963

Journal of Endocrinology

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l-Thyroxine and 3,5,3\m='\-triiodo-l-thyronine in concentrations of 10\m=-\8m to 10\m=-\5m were shown to increase the oxygen uptake and water transfer down an osmotic gradient in the isolated urinary bladder of Bufo bufo. The increase in water transport after treatment with thyroxine and triiodothyronine was related linearly to the log dose. The increase in O2 uptake and water movement in equimolar concentrations of thyroxine and triiodothyronine were similar but the responses to the latter were more rapid.Substitution of sodium ions by choline in the incubation medium resulted in a fall of oxygen uptake by the bladder, and a slight lowering of water loss. When thyroxine was added, oxygen uptake increased to the same extent in both media but only in sodium saline did water loss increase greatly.Specific enzyme inhibitors prevented the thyroxine-induced increase in water loss across the isolated toad bladder, indicating that metabolic energy is necessary for this alteration in permeability. Triiodothyronine and thyroxine caused an increased water loss across the isolated toad bladder when placed on either the mucosal or serosal surface.Two analogues of the thyroid hormones, 3,5,3\m='\-triiodothyroacetic acid and 3,5,3\m='\,5-tetraiodothyroacetic acid, caused an extremely rapid, but transient, movement of water across the bladder; their action and that of triiodothyronine and thyroxine is compared.An hypothesis is proposed tentatively to account for the mode of action of thyroxine on the permeability of the isolated toad bladder, taking into account the close relationship between increases in water permeability and metabolism, particularly that involving sodium transport.

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Section: Discussionmentioning

confidence: 95%

Permeability and Respiration Effects of Thyroidal Hormones on the Isolated Bladder of the Toad Bufo Bufo

Matty¹,

Green²

1963

Journal of Endocrinology

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“…Bonnet (1926) recorded an increase in oxygen consumption of about 32% in frogs fed 0.25 to 0.50 g of beef meat. Beef liver fed to Rana pipiens increased oxygen consumption 44% (Warren, 1940).…”

Section: Seasonal Differences In Oxygen Consumption Of Awake Toads-mmentioning

confidence: 99%

Energy Metabolism of Dormant Spadefoot Toads (Scaphiopus)

Seymour¹

1973

Copeia

109

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“…modulation of hormone activity, synthesis, secretion, degradation, transport or receptor activity). There is mounting evidence that hormones of one endocrine axis influence other endocrine axes in juveniles and adults of multiple vertebrate taxa: notably in mammals (Dittrich et al, 2011;Jiang et al, 2001;Maran, 2003;Wagner et al, 2008), fish (Cyr and Eales, 1996;Duarte-Guterman et al, 2014;Hernández-Puga et al, 2016;Matta et al, 2002;Swapna et al, 2006), and amphibians (Duarte-Guterman et al, 2014;Warren, 1940); however, there is relatively less information on this cross-talk for vertebrate early life stages, particularly in fish. In lower vertebrates like teleost fishes, the presence of hormones from multiple endocrine axes in early life stages has been demonstrated (Cyr and Eales, 1996;Habibi et al, 2012;Leet et al, 2011), yet the underlying mechanisms and the extent of HPG and HPT axis cross-talk during these early life stages in teleosts are not clear.…”

Section: Fish Endocrinologymentioning

confidence: 99%

Reproductive and thyroid endocrine axis cross-talk in rainbow trout (Oncorhynchus mykiss) alevins

Hegeman

Marlatt

2021

General and Comparative Endocrinology

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Although numerous studies on various aspects of endocrine axes and the physiology of both juvenile and adult life stages of several teleosts exists, studies characterizing the basic functions and cross-talk of endocrine axes during early developmental stages (i.e. embryonic to early feeding fry), in particular, are limited. The goal of this study was to characterize morphological and molecular effects in rainbow trout alevins after waterborne exposures to 17β-estradiol (E2 0.0008 to 0.5 μg/L), triiodothyronine (T3; 0.52 to 65 μg/L), and various co-treatments for 21 to 23 days. Interestingly, there was no consistent evidence that E2 alone influenced growth, development or deformity rates, nor the co-treatments of 0.02 and 0.1 μg/L of E2 with up to 65 μg/L of T3. However, 13 and 65 μg/L T3 alone expedited development and caused a unique opercular deformity not previously reported. Gene expression changes were observed, but these were mainly at the highest concentrations tested. These data suggest low-level E2 does not negate abnormal growth and development caused by hyperthyroidism and examining more time points is likely required to demonstrate a stronger response profile for individual hormones and endocrine axes cross-talk.

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Studies on the effect of experimental hyperthyroidism on the adult frog, Rana pipiens, schreber

Cited by 40 publications

References 26 publications

Permeability and Respiration Effects of Thyroidal Hormones on the Isolated Bladder of the Toad Bufo Bufo

Permeability and Respiration Effects of Thyroidal Hormones on the Isolated Bladder of the Toad Bufo Bufo

Energy Metabolism of Dormant Spadefoot Toads (Scaphiopus)

Reproductive and thyroid endocrine axis cross-talk in rainbow trout (Oncorhynchus mykiss) alevins

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